User profiles for Ibrahim Y. Hachim
Ibrahim HachimUniversity of Sharjah Verified email at sharjah.ac.ae Cited by 1057 |
[HTML][HTML] Dasatinib sensitises triple negative breast cancer cells to chemotherapy by targeting breast cancer stem cells
Background Patients with triple negative breast cancer (TNBC) exhibit poor prognosis and
are at high risk of tumour relapse, due to the resistance to chemotherapy. These aggressive …
are at high risk of tumour relapse, due to the resistance to chemotherapy. These aggressive …
[HTML][HTML] D-dimer, troponin, and urea level at presentation with COVID-19 can predict ICU admission: a single centered study
Background: Identifying clinical-features or a scoring-system to predict a benefit from hospital
admission for patients with COVID-19 can be of great value for the decision-makers in the …
admission for patients with COVID-19 can be of great value for the decision-makers in the …
[HTML][HTML] Cyclooxygenase-2 regulates TGFβ-induced cancer stemness in triple-negative breast cancer
Triple negative breast cancer (TNBC), an aggressive subtype of breast cancer, display poor
prognosis and exhibit resistance to conventional therapies, partly due to an enrichment in …
prognosis and exhibit resistance to conventional therapies, partly due to an enrichment in …
Prolactin receptor expression is an independent favorable prognostic marker in human breast cancer
Prolactin (PRL) hormone plays an important role in the development of the mammary gland
and terminal differentiation of the mammary epithelial cells. While initial studies suggested …
and terminal differentiation of the mammary epithelial cells. While initial studies suggested …
Discovery of novel papain-like protease inhibitors for potential treatment of COVID-19
The recent emergence of different SARS-CoV-2 variants creates an urgent need to develop
more effective therapeutic agents to prevent COVID-19 outbreaks. Among SARS-CoV-2 …
more effective therapeutic agents to prevent COVID-19 outbreaks. Among SARS-CoV-2 …
[HTML][HTML] CPSF6 is a clinically relevant breast cancer vulnerability target: role of CPSF6 in breast cancer
Breast cancer represents a major health challenge. The majority of breast cancer deaths
are due to cancer progression/recurrence for which no efficient therapies exist. Aggressive …
are due to cancer progression/recurrence for which no efficient therapies exist. Aggressive …
[HTML][HTML] Prolactin pro-differentiation pathway in triple negative breast cancer: impact on prognosis and potential therapy
Triple negative breast cancer (TNBC) is a heterogeneous disease associated with poor
clinical outcome and lack of targeted therapy. Here we show that prolactin (PRL) and its …
clinical outcome and lack of targeted therapy. Here we show that prolactin (PRL) and its …
[HTML][HTML] Understanding the role of innate immune cells and identifying genes in breast cancer microenvironment
The innate immune system is the first line of defense against invading pathogens and has a
major role in clearing transformed cells, besides its essential role in activating the adaptive …
major role in clearing transformed cells, besides its essential role in activating the adaptive …
Differential expression of TGFβ isoforms in breast cancer highlights different roles during breast cancer progression
While TGFβ plays a critical role in tumor formation and progression, the role and contribution
of its three different isoforms remain unclear. In this study, we aimed at elucidating the …
of its three different isoforms remain unclear. In this study, we aimed at elucidating the …
[HTML][HTML] Clinical and laboratory profile of hospitalized symptomatic COVID-19 patients: case series study from the first COVID-19 center in the UAE
Introduction COVID-19 is raising with a second wave threatening many countries. Therefore,
it is important to understand COVID-19 characteristics across different countries. Methods …
it is important to understand COVID-19 characteristics across different countries. Methods …