Calreticulin is a Ca 2+ -binding chaperone in the endoplasmic reticulum (ER), and calreticulin
gene knockout is embryonic lethal. Here, we used calreticulin-deficient mouse embryonic …

Multiple sclerosis (MS) is a chronic inflammatory-demyelinating disease of the nervous system.
There has been mounting evidence showing that MS is associated with increased risk of …

Calnexin and calreticulin are molecular chaperones, which are involved in the protein folding,
assembly, and retention/retrieval. We know that calreticulin-deficiency is lethal in utero, …

Methotrexate (MTX) is a chemotherapeutic synthetic(s) phase cell cycle inhibitor, and its role
has evolved as an immunological agent in autoimmune diseases like rheumatoid arthritis, …

Background Pulmonary thromboendarterectomy (PTE) is the treatment of choice for eligible
patients with chronic thromboembolic pulmonary hypertension (CTEPH). However, access to …

Introduction: Palbociclib is a cyclin-dependent kinase inhibitor that is used in hormone receptor
positive and HER-2 negative metastatic breast cancer. It has shown promising results as …

Left ventricular assist devices (LVADs) are an exceedingly important form of mechanical
support for patients with end-stage heart failure. LVADs can be utilized both as a bridge to …

Background Hepatitis B and C need immediate worldwide attention as the infection rates are
too high. More than 240 million people have chronic (long-term) liver infections. Every year, …

Background: Syncope is a symptom complex comprising of a brief loss of consciousness
leading to a transient decrease in cerebral blood flow that resolves completely. 2D-…

Organophosphate poisoning is common following accidental or suicidal ingestion. Cases
have been reported with different neurological consequences including acute cholinergic …