Background Diagnosing asthma in children represents an important clinical challenge. There
is no single gold-standard test to confirm the diagnosis. Consequently, over- and under-…

Rationale: The prognostic value of cardiopulmonary exercise testing (CPET) for survival in
cystic fibrosis (CF) in the context of current clinical management, when controlling for other …

Background The multiple breath nitrogen washout (N 2 MBW) technique is increasingly
used to assess the degree of ventilation inhomogeneity in school-aged children with lung …

Background Early-life respiratory tract infections might affect chronic obstructive respiratory
diseases, but conclusive studies from general populations are lacking. Our objective was to …

Despite the attractiveness of breath analysis as a non-invasive means to retrieve relevant
metabolic information, its introduction into routine clinical practice remains a challenge. Among …

Background Adverse effects of higher air pollution levels before and after birth on
subsequent lung function are often reported in the literature. We assessed whether low-to-moderate …

Glucocorticoids represent the mainstay therapy for many lung diseases, providing
outstanding management of asthma but performing surprisingly poorly in patients with acute …

Rationale: Infants born prematurely have impaired capacity to deal with oxidative stress shortly
after birth. Objectives: We hypothesize that the relative impact of exposure to air pollution …

Background Air pollution and greenness are associated with short- and long-term respiratory
health in children but the underlying mechanisms are only scarcely investigated. The nasal …

Background Therapeutic management of epilepsy remains a challenge, since optimal
systemic antiseizure medication (ASM) concentrations do not always correlate with improved …