Immunological decision‐making: how does the immune system decide to mount a helper T‐cell response?
Aberrant T‐cell responses underpin a range of diseases, including asthma and allergy and
autoimmune diseases. Pivotal immune elements of these diseases are the development of …
autoimmune diseases. Pivotal immune elements of these diseases are the development of …
[PDF][PDF] Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages
The Krebs cycle-derived metabolite itaconate and its derivatives suppress the inflammatory
response in pro-inflammatory "M1" macrophages. However, alternatively activated "M2" …
response in pro-inflammatory "M1" macrophages. However, alternatively activated "M2" …
Role for NLRP3 inflammasome–mediated, IL-1β–dependent responses in severe, steroid-resistant asthma
…, LAJ O'Neill, MA Cooper, JC Horvat… - American journal of …, 2017 - atsjournals.org
Rationale: Severe, steroid-resistant asthma is the major unmet need in asthma therapy.
Disease heterogeneity and poor understanding of pathogenic mechanisms hampers the …
Disease heterogeneity and poor understanding of pathogenic mechanisms hampers the …
A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis
BACKGROUND: Cigarette smoke–induced chronic obstructive pulmonary disease (COPD)
is a life-threatening inflammatory disorder of the lung. The development of effective therapies …
is a life-threatening inflammatory disorder of the lung. The development of effective therapies …
Interferon-ε protects the female reproductive tract from viral and bacterial infection
The innate immune system senses pathogens through pattern-recognition receptors (PRRs)
that signal to induce effector cytokines, such as type I interferons (IFNs). We characterized …
that signal to induce effector cytokines, such as type I interferons (IFNs). We characterized …
MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase–mediated suppression of histone deacetylase 2
RY Kim, JC Horvat, JW Pinkerton, MR Starkey… - Journal of Allergy and …, 2017 - Elsevier
Background Severe steroid-insensitive asthma is a substantial clinical problem. Effective
treatments are urgently required, however, their development is hampered by a lack of …
treatments are urgently required, however, their development is hampered by a lack of …
Necroptosis signaling promotes inflammation, airway remodeling, and emphysema in chronic obstructive pulmonary disease
…, GG Brusselle, JC Horvat… - American journal of …, 2021 - atsjournals.org
Rationale: Necroptosis, mediated by RIPK3 (receptor-interacting protein kinase 3) and MLKL
(mixed lineage kinase domain-like), is a form of regulated necrosis that can drive tissue …
(mixed lineage kinase domain-like), is a form of regulated necrosis that can drive tissue …
[HTML][HTML] Haemophilus influenzae Infection Drives IL-17-Mediated Neutrophilic Allergic Airways Disease
AT Essilfie, JL Simpson, JC Horvat, JA Preston… - PLoS …, 2011 - journals.plos.org
A subset of patients with stable asthma has prominent neutrophilic and reduced eosinophilic
inflammation, which is associated with attenuated airways hyper-responsiveness (AHR). …
inflammation, which is associated with attenuated airways hyper-responsiveness (AHR). …
A microRNA-21–mediated SATB1/S100A9/NF-κB axis promotes chronic obstructive pulmonary disease pathogenesis
…, G Caramori, PS Foster, JC Horvat… - Science Translational …, 2021 - science.org
Chronic obstructive pulmonary disease (COPD) is the third leading cause of morbidity and
death worldwide. Inhalation of cigarette smoke (CS) is the major cause in developed countries…
death worldwide. Inhalation of cigarette smoke (CS) is the major cause in developed countries…
Inflammasomes in the lung
Innate immune responses act as first line defences upon exposure to potentially noxious
stimuli. The innate immune system has evolved numerous intracellular and extracellular …
stimuli. The innate immune system has evolved numerous intracellular and extracellular …