Role of AhR in positive regulation of cell proliferation and survival

J Yin, B Sheng, Y Qiu, K Yang, W Xiao… - Cell proliferation, 2016 - Wiley Online Library
The aryl hydrocarbon receptor (AhR) is an important nuclear transcription factor that is best
known for mediating toxic responses by adjusting numbers of metabolism‐related enzymes, …

The role of hypoxia‐inducible factor 1‐alpha in inflammatory bowel disease

J Yin, Y Ren, K Yang, W Wang, T Wang… - Cell Biology …, 2022 - Wiley Online Library
Inflammatory bowel disease (IBD) develops as a result of a combination of genetic
predisposition, dysbiosis of the gut microbiota, and environmental influences, which is mainly …

The protective roles of NLRP 6 in intestinal epithelial cells

J Yin, B Sheng, K Yang, L Sun, W Xiao… - Cell proliferation, 2019 - Wiley Online Library
The evolution of chronic inflammatory diseases is thought to be due to a combination of host
genetic variations and environmental factors that include the alteration of intestinal flora, …

SCFAs induce autophagy in intestinal epithelial cells and relieve colitis by stabilizing HIF-1α

C Zhou, L Li, T Li, L Sun, J Yin, H Guan, L Wang… - Journal of Molecular …, 2020 - Springer
Hypoxia-inducible factor-1α (HIF-1α) is a critical regulator of barrier integrity during colonic
mucosal injury. Previous works have shown that the absence of autophagy is implicated in …

[HTML][HTML] Aryl hydrocarbon receptor inhibits inflammation in DSS‑induced colitis via the MK2/p‑MK2/TTP pathway

…, K Yang, B Han, B Sheng, J Yin… - International …, 2018 - spandidos-publications.com
The pathogenesis of inflammatory bowel disease (IBD) is believed to be associated with the
abnormal expression of inflammatory factors. The aryl hydrocarbon receptor (AhR) is a …

Aryl hydrocarbon receptor activation in intestinal obstruction ameliorates intestinal barrier dysfunction via suppression of MLCK-MLC phosphorylation pathway

B Han, B Sheng, Z Zhang, A Pu, J Yin, Q Wang, K Yang… - Shock, 2016 - journals.lww.com
Background: Accumulating evidence suggests that the aryl hydrocarbon receptor (AhR) plays
an important role in the maintenance of the function of the intestinal barrier in patients with …

Mutual regulation between butyrate and hypoxia‐inducible factor‐1α in epithelial cell promotes expression of tight junction proteins

J Yin, C Zhou, K Yang, Y Ren, Y Qiu, P Xu… - Cell biology …, 2020 - Wiley Online Library
Inflammatory bowel disease is a kind of multi‐aetiological chronic disease that is driven by
multidimensional factors. Hypoxia‐inducible factor‐1α (HIF‐1α) plays an important role in anti…

Aryl hydrocarbon receptor activation alleviates dextran sodium sulfate-induced colitis through enhancing the differentiation of goblet cells

J Yin, K Yang, C Zhou, P Xu, W Xiao, H Yang - … and biophysical research …, 2019 - Elsevier
Background The intestinal inflammation induces disruption of the intestinal barrier function
and leads to bacteria invasion. Accumulating evidences revealed that the aryl hydrocarbon …

[HTML][HTML] Identification and verification of YBX3 and its regulatory gene HEIH as an oncogenic system: A multidimensional analysis in colon cancer

…, Z Li, W Wang, X Zhang, W Li, G Du, J Yin… - Frontiers in …, 2022 - frontiersin.org
The novel gene YBX3 is important for regulating translation and RNA catabolism and
encodes a protein with a highly conserved cold-shock domain. However, its pathogenic roles …

[HTML][HTML] Antifungal treatment aggravates sepsis through the elimination of intestinal fungi

…, Y Chen, L Sun, P Xu, B Han, X Li, J Yin… - … Medicine and Cellular …, 2021 - hindawi.com
Prophylactic antifungal therapy is widely adopted clinically for critical patients and effective
in reducing the morbidity of invasive fungal infection and improves outcomes of those …