User profiles for Karl A. Holden

Karl A Holden

Clinical Research Fellow in Children's Respiratory Health
Verified email at liverpool.ac.uk
Cited by 7653

Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study

…, HE Hardwick, R Pius, L Norman, KA Holden… - bmj, 2020 - bmj.com
Objective To characterise the clinical features of patients admitted to hospital with coronavirus
disease 2019 (covid-19) in the United Kingdom during the growth phase of the first wave …

Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C …

…, R Gupta, S Halpin, HE Hardwick, KA Holden… - bmj, 2020 - bmj.com
Objective To develop and validate a pragmatic risk score to predict mortality in patients admitted
to hospital with coronavirus disease 2019 (covid-19). Design Prospective observational …

Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study

OV Swann, KA Holden, L Turtle, L Pollock, CJ Fairfield… - bmj, 2020 - bmj.com
Objective To characterise the clinical features of children and young people admitted to
hospital with laboratory confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-…

Features of 16,749 hospitalised UK patients with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol

…, CA Green, H Hardwick, R Pius, L Norman, KA Holden… - MedRxiv, 2020 - medrxiv.org
Structured abstract Objective To characterize the clinical features of patients with severe
COVID-19 in the UK. Design Prospective observational cohort study with rapid data gathering …

[HTML][HTML] Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study

…, S Halpin, HE Hardwick, KA Holden… - The Lancet …, 2021 - thelancet.com
Background Prognostic models to predict the risk of clinical deterioration in acute COVID-19
cases are urgently required to inform clinical management decisions. Methods We …

[HTML][HTML] Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective …

…, A Ho, OV Swann, M Sullivan, F Soares, KA Holden… - The Lancet, 2021 - thelancet.com
Background COVID-19 is a multisystem disease and patients who survive might have in-hospital
complications. These complications are likely to have important short-term and long-…

European Respiratory Society clinical practice guidelines for the diagnosis of asthma in children aged 5–16 years

…, S Turner, M Goutaki, KA Holden… - European respiratory …, 2021 - Eur Respiratory Soc
Background Diagnosing asthma in children represents an important clinical challenge. There
is no single gold-standard test to confirm the diagnosis. Consequently, over- and under-…

[HTML][HTML] Ethnicity and outcomes from COVID-19: the ISARIC CCP-UK prospective observational cohort study of hospitalised patients

…, C Griffiths, S Halpin, HE Hardwick, A Ho, KA Holden… - 2020 - papers.ssrn.com
Background: Reports of ethnic inequalities in COVID-19 outcomes are conflicting and the
reasons for any differences in outcomes are unclear. We investigated ethnic inequalities in …

Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol

…, CA Green, S Halpin, HE Hardwick, KA Holden… - Thorax, 2022 - thorax.bmj.com
Purpose To prospectively validate two risk scores to predict mortality (4C Mortality) and in-hospital
deterioration (4C Deterioration) among adults hospitalised with COVID-19. Methods …

Fungal sensitization and positive fungal culture from sputum in children with asthma are associated with reduced lung function and acute asthma attacks respectively

KG Welsh, KA Holden, AJ Wardlaw… - Clinical & …, 2021 - Wiley Online Library
Background Sensitization to thermotolerant fungi, including filamentous fungi and Candida
albicans, is associated with poor lung function in adults with severe asthma. Data in children …