User profiles for Karl A. Holden
Karl A HoldenClinical Research Fellow in Children's Respiratory Health Verified email at liverpool.ac.uk Cited by 7653 |
Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study
Objective To characterise the clinical features of patients admitted to hospital with coronavirus
disease 2019 (covid-19) in the United Kingdom during the growth phase of the first wave …
disease 2019 (covid-19) in the United Kingdom during the growth phase of the first wave …
Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C …
…, R Gupta, S Halpin, HE Hardwick, KA Holden… - bmj, 2020 - bmj.com
Objective To develop and validate a pragmatic risk score to predict mortality in patients admitted
to hospital with coronavirus disease 2019 (covid-19). Design Prospective observational …
to hospital with coronavirus disease 2019 (covid-19). Design Prospective observational …
Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study
Objective To characterise the clinical features of children and young people admitted to
hospital with laboratory confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-…
hospital with laboratory confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-…
Features of 16,749 hospitalised UK patients with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol
Structured abstract Objective To characterize the clinical features of patients with severe
COVID-19 in the UK. Design Prospective observational cohort study with rapid data gathering …
COVID-19 in the UK. Design Prospective observational cohort study with rapid data gathering …
[HTML][HTML] Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study
…, S Halpin, HE Hardwick, KA Holden… - The Lancet …, 2021 - thelancet.com
Background Prognostic models to predict the risk of clinical deterioration in acute COVID-19
cases are urgently required to inform clinical management decisions. Methods We …
cases are urgently required to inform clinical management decisions. Methods We …
[HTML][HTML] Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective …
Background COVID-19 is a multisystem disease and patients who survive might have in-hospital
complications. These complications are likely to have important short-term and long-…
complications. These complications are likely to have important short-term and long-…
European Respiratory Society clinical practice guidelines for the diagnosis of asthma in children aged 5–16 years
Background Diagnosing asthma in children represents an important clinical challenge. There
is no single gold-standard test to confirm the diagnosis. Consequently, over- and under-…
is no single gold-standard test to confirm the diagnosis. Consequently, over- and under-…
[HTML][HTML] Ethnicity and outcomes from COVID-19: the ISARIC CCP-UK prospective observational cohort study of hospitalised patients
Background: Reports of ethnic inequalities in COVID-19 outcomes are conflicting and the
reasons for any differences in outcomes are unclear. We investigated ethnic inequalities in …
reasons for any differences in outcomes are unclear. We investigated ethnic inequalities in …
Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol
Purpose To prospectively validate two risk scores to predict mortality (4C Mortality) and in-hospital
deterioration (4C Deterioration) among adults hospitalised with COVID-19. Methods …
deterioration (4C Deterioration) among adults hospitalised with COVID-19. Methods …
Fungal sensitization and positive fungal culture from sputum in children with asthma are associated with reduced lung function and acute asthma attacks respectively
KG Welsh, KA Holden, AJ Wardlaw… - Clinical & …, 2021 - Wiley Online Library
Background Sensitization to thermotolerant fungi, including filamentous fungi and Candida
albicans, is associated with poor lung function in adults with severe asthma. Data in children …
albicans, is associated with poor lung function in adults with severe asthma. Data in children …