Leptin is a multifunctional adipose-derived cytokines that play a critical role in bodyweight
homeostasis and energy balance. Recently, leptin and leptin receptor dysreulation have been …

Phosphatidylinositol 3′-kinase (PI3K) is a key player in cell-growth signaling in a number of
lymphoid malignancies, but its role in diffuse large B-cell lymphoma (DLBCL) has not been …

Context: Genetic aberration in phosphatidylinositol 3-kinase (PI3K)/AKT pathway has been
detected in numerous and diverse human cancers. PIK3CA, which encodes for the catalytic …

Background A number of constitutively activated signaling pathways play critical roles in the
survival and growth of primary effusion lymphoma cells (PELs) including NFkB and PI3/AKT …

To identify genes potentially playing an important role in the progression of colorectal carcinoma
(CRC), we screened global gene expression using cDNA expression array on 41 CRC …

Primary effusion lymphoma (PEL) is an incurable, aggressive B-cell malignancy that develops
rapid resistance to conventional chemotherapy. In efforts to identify novel approaches to …

Background Recent epidemiological studies have suggested that obesity is associated with
ovarian cancer. Obesity hormone leptin and its receptor (Ob-R) contribute to tumor …

Cyclooxygenase‐2 (COX‐2) expression contributes to tumor growth and invasion in
epithelial ovarian cancer (EOC). COX‐2 inhibitors exhibit important anticarcinogenic potential …

We provide evidence that thymoquinone (TQ), a natural compound isolated from Nigella sativa,
induces growth inhibition and apoptosis in several primary effusion lymphoma (PEL) cell …

We provide evidence that curcumin, a natural compound isolated from rhizomes of plant
Curcuma longa, induces apoptosis in several Burkitt's lymphoma cell lines expressing Bax …