Pharmacogenomics of genetic polymorphism within the genes responsible for SARS‐CoV‐2 susceptibility and the drug‐metabolising genes used in treatment

LN ALEitan, SZ Alahmad - Reviews in medical virology, 2021 - Wiley Online Library
The ongoing outbreak of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)
represents a significant challenge to international health. Pharmacogenomics aims to identify …

[HTML][HTML] Metformin pharmacogenetics: effects of SLC22A1, SLC22A2, and SLC22A3 polymorphisms on glycemic control and HbA1c levels

LN Al-Eitan, BA Almomani, AM Nassar… - Journal of personalized …, 2019 - mdpi.com
Type 2 diabetes mellitus (T2DM) constitutes a major portion of Jordan’s disease burden, and
incidence rates are rising at a rapid rate. Due to variability in the drug’s response between …

[HTML][HTML] Effects of CYP2C9 and VKORC1 polymorphisms on warfarin sensitivity and responsiveness during the stabilization phase of therapy

LN Al-Eitan, AY Almasri, RH Khasawneh - Saudi Pharmaceutical Journal, 2019 - Elsevier
The main objective of this study is to assess the effects of CYP2C9 and VKORC1
polymorphisms on warfarin sensitivity and responsiveness in a Jordanian population during the …

[HTML][HTML] Impact of CYP2C9 and VKORC1 Polymorphisms on Warfarin Sensitivity and Responsiveness in Jordanian Cardiovascular Patients during the Initiation …

LN Al-Eitan, AY Almasri, RH Khasawneh - Genes, 2018 - mdpi.com
Warfarin is an oral anticoagulant frequently used in the treatment of different cardiovascular
diseases. Genetic polymorphisms in the CYP2C9 and VKORC1 genes have produced …

Vitamin E protects against cisplatin-induced genotoxicity in human lymphocytes

LN Al-Eitan, KH Alzoubi, LI Al-Smadi, OF Khabour - Toxicology In Vitro, 2020 - Elsevier
Cisplatin is an anticancer drug that is widely used in treatments of human malignancies such
as ovaries,’ testes,’ and solid tumors of the head and neck. However, the use of cisplatin in …

[HTML][HTML] Genetic susceptibility of opioid receptor genes polymorphism to drug addiction: A candidate-gene association study

LN Al-Eitan, DM Rababa'h, MA Alghamdi - BMC psychiatry, 2021 - Springer
Background Like other complex diseases including drug addiction, genetic factors can interfere
with the disease. In this study, three opioid genes (OPRM1, OPRD1, and OPRK1) were …

Practical challenges and translational issues in pharmacogenomics and personalized medicine from 2010 onwards

LN AL-Eitan, AH Tarkhan - Current Pharmacogenomics and …, 2016 - ingentaconnect.com
Background: Practical challenges and translational issues have affected the widespread
implementation of pharmacogenomics and personalized medicine. There are significant …

Effects of MTHFR and ABCC2 gene polymorphisms on antiepileptic drug responsiveness in Jordanian epileptic patients

LN Al-Eitan, IM Al-Dalalah, MM Mustafa… - Pharmacogenomics …, 2019 - Taylor & Francis
Background Epilepsy is one of the most common neurological diseases with unclear
etiology where its genetic background and treatment regime still need further exploration. …

The association between serum vitamin D3 levels and autism among Jordanian boys

L Alzghoul, LN Al-Eitan, M Aladawi, M Odeh… - Journal of autism and …, 2020 - Springer
This study assesses the correlation between vitamin-D deficiency and autism spectrum
disorder (ASD) in Jordan. We performed a case–controlled cross-sectional analysis to assess …

[HTML][HTML] Transcriptome analysis of HPV-induced warts and healthy skin in humans

LN Al-Eitan, AH Tarkhan, MA Alghamdi… - BMC Medical …, 2020 - Springer
Background The human papillomaviruses (HPV) are a group of viruses that, depending on
the strain, can cause cancer or the formation of benign growths known as warts. Scarce …