User profiles for Martin Lee
 | Lee J. Martin, Ph.D.Johns Hopkins University, Professor, Pathology & Neuroscience, Director, Pathobiology … Verified email at jhmi.edu Cited by 35955 |
Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis
The pathogenesis of sporadic amyotrophic lateral sclerosis (ALS) is unknown, but defects in
synaptosomal high‐affinity glutamate transport have been observed. In experimental models…
synaptosomal high‐affinity glutamate transport have been observed. In experimental models…
[HTML][HTML] Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis
Background. Amyotrophic lateral sclerosis (ALS) is a chronic degenerative neurologic
disorder characterized by the death of motor neurons in the cerebral cortex and spinal cord. …
disorder characterized by the death of motor neurons in the cerebral cortex and spinal cord. …
Localization of neuronal and glial glutamate transporters
The cellular and subcellular distributions of the glutamate transporter subtypes EAACl, CLT-1,
and CIAST in the rat CNS were demonstrated using anti-peptide antibodies that recognize …
and CIAST in the rat CNS were demonstrated using anti-peptide antibodies that recognize …
Parkinson's disease α-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death
LJ Martin, Y Pan, AC Price, W Sterling… - Journal of …, 2006 - Soc Neuroscience
α-Synuclein (α-Syn) is enriched in nerve terminals. Two mutations in the α-Syn gene (Ala53→
Thr and Ala30→ Pro) occur in autosomal dominant familial Parkinson's disease. Mice …
Thr and Ala30→ Pro) occur in autosomal dominant familial Parkinson's disease. Mice …
Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death.
…, HC Pant, RO Brady, LJ Martin… - Proceedings of the …, 1996 - National Acad Sciences
Although cyclin-dependent kinase 5 (Cdk5) is closely related to other cyclin-dependent
kinases, its kinase activity is detected only in the postmitotic neurons. Cdk5 expression and …
kinases, its kinase activity is detected only in the postmitotic neurons. Cdk5 expression and …
Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.
In the brains of aged humans and cases of Alzheimer disease, deposits of amyloid in senile
plaques are located in proximity to nerve processes. The principal component of this …
plaques are located in proximity to nerve processes. The principal component of this …
[HTML][HTML] Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: a perspective on the contributions of apoptosis and necrosis
LJ Martin, NA Al-Abdulla, AM Brambrink, JR Kirsch… - Brain research …, 1998 - Elsevier
In the human brain and spinal cord, neurons degenerate after acute insults (eg, stroke,
cardiac arrest, trauma) and during progressive, adult-onset diseases [eg, amyotrophic lateral …
cardiac arrest, trauma) and during progressive, adult-onset diseases [eg, amyotrophic lateral …
Comparison of vignettes, standardized patients, and chart abstraction: a prospective validation study of 3 methods for measuring quality
…, J Luck, P Glassman, TR Dresselhaus, M Lee - Jama, 2000 - jamanetwork.com
ContextBetter health care quality is a universal goal, yet measuring quality has proven to be
difficult and problematic. A central problem has been isolating physician practices from other …
difficult and problematic. A central problem has been isolating physician practices from other …
An exclusively human milk-based diet is associated with a lower rate of necrotizing enterocolitis than a diet of human milk and bovine milk-based products
…, G Dudell, EA Cristofalo, P Meier, ML Lee… - The Journal of …, 2010 - Elsevier
OBJECTIVE: To evaluate the health benefits of an exclusively human milk–based diet compared
with a diet of both human milk and bovine milk–based products in extremely premature …
with a diet of both human milk and bovine milk–based products in extremely premature …
Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trials
OM Calof, AB Singh, ML Lee, AM Kenny… - The Journals of …, 2005 - academic.oup.com
Background. We performed a meta-analysis of randomized clinical trials to determine the
risks of adverse events associated with testosterone replacement in older men. Methods. The …
risks of adverse events associated with testosterone replacement in older men. Methods. The …