User profiles for Matthias Frank

Matthias Frank

University of Bonn
Verified email at cs.uni-bonn.de
Cited by 1830

Femtosecond X-ray protein nanocrystallography

…, M Messerschmidt, JD Bozek, SP Hau-Riege, M Frank… - Nature, 2011 - nature.com
X-ray crystallography provides the vast majority of macromolecular structures, but the success
of the method relies on growing crystals of sufficient size. In conventional measurements, …

[HTML][HTML] Femtosecond diffractive imaging with a soft-X-ray free-electron laser

HN Chapman, A Barty, MJ Bogan, S Boutet, M Frank… - Nature Physics, 2006 - nature.com
Abstract Theory predicts 1 , 2 , 3 , 4 that, with an ultrashort and extremely bright coherent X-ray
pulse, a single diffraction pattern may be recorded from a large macromolecule, a virus or …

Single mimivirus particles intercepted and imaged with an X-ray laser

…, RB Doak, S Marchesini, SP Hau-Riege, M Frank… - Nature, 2011 - nature.com
X-ray lasers offer new capabilities in understanding the structure of biological systems,
complex materials and matter under extreme conditions 1 , 2 , 3 , 4 . Very short and extremely …

Natively Inhibited Trypanosoma brucei Cathepsin B Structure Determined by Using an X-ray Laser

…, TC Chao, RB Doak, H Fleckenstein, M Frank… - Science, 2013 - science.org
The Trypanosoma brucei cysteine protease cathepsin B (TbCatB), which is involved in host
protein degradation, is a promising target to develop new treatments against sleeping …

Time-resolved serial crystallography captures high-resolution intermediates of photoactive yellow protein

…, S Basu, N Zatsepin, K Pande, D Milathianaki, M Frank… - Science, 2014 - science.org
Serial femtosecond crystallography using ultrashort pulses from x-ray free electron lasers (XFELs)
enables studies of the light-triggered dynamics of biomolecules. We used …

Serial time-resolved crystallography of photosystem II using a femtosecond X-ray laser

…, GJ Williams, S Boutet, RB Doak, U Weierstall, M Frank… - Nature, 2014 - nature.com
Photosynthesis, a process catalysed by plants, algae and cyanobacteria converts sunlight
to energy thus sustaining all higher life on Earth. Two large membrane protein complexes, …

Femtosecond structural dynamics drives the trans/cis isomerization in photoactive yellow protein

…, A Ourmazd, P Schwander, U Weierstall, M Frank… - Science, 2016 - science.org
A variety of organisms have evolved mechanisms to detect and respond to light, in which the
response is mediated by protein structural changes after photon absorption. The initial step …

Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages

…, E Sanchez-Padilla, M Bonnet, A Gil-Brusola, M Frank… - Nature …, 2016 - nature.com
Generalist and specialist species differ in the breadth of their ecological niches. Little is known
about the niche width of obligate human pathogens. Here we analyzed a global collection …

[BOOK][B] Ambisonics: A practical 3D audio theory for recording, studio production, sound reinforcement, and virtual reality

F Zotter, M Frank - 2019 - library.oapen.org
This open access book provides a concise explanation of the fundamentals and background
of the surround sound recording and playback technology Ambisonics. It equips readers …

Single particle X-ray diffractive imaging

…, WH Benner, S Boutet, U Rohner, M Frank… - Nano …, 2008 - ACS Publications
In nanotechnology, strategies for the creation and manipulation of nanoparticles in the gas
phase are critically important for surface modification and substrate-free characterization. …