User profiles for Mesfer M. Al Shahrani

Dr. Mesfer Al Shahrani

Associate Professor of Clinical Biochemistry
Verified email at kku.edu.sa
Cited by 304

[HTML][HTML] Oxidative stress: mechanistic insights into inherited mitochondrial disorders and Parkinson's disease

M Al Shahrani, S Heales, I Hargreaves… - Journal of Clinical …, 2017 - mdpi.com
Oxidative stress arises when cellular antioxidant defences become overwhelmed by a
surplus generation of reactive oxygen species (ROS). Once this occurs, many cellular …

Drug-induced mitochondrial toxicity

IP Hargreaves, M Al Shahrani, L Wainwright… - Drug safety, 2016 - Springer
The mitochondrial respiratory chain (MRC) and ATP synthase (complex V) play an essential
role in cellular energy production by the process of oxidative phosphorylation. In addition to …

[HTML][HTML] Hemoglobinopathies: An update on the prevalence trends in Southern Saudi Arabia

…, S Alasmari, AA Hawan, MM Al Shahrani… - Saudi Medical …, 2021 - ncbi.nlm.nih.gov
Objectives: To investigate trends in hemoglobinopathies following the establishment of a
mandatory premarital screening program (MPMSP) in the southern region of Saudi Arabia, …

Pioneering a paradigm shift in tissue engineering and regeneration with polysaccharides and proteins-based scaffolds: A comprehensive review

…, S Paramshetti, RM Gahtani, M Al Shahrani… - International Journal of …, 2024 - Elsevier
In the realm of modern medicine, tissue engineering and regeneration stands as a beacon
of hope, offering the promise of restoring form and function to damaged or diseased organs …

[HTML][HTML] Mitochondrial dysfunction is a key pathological driver of early stage Parkinson's

…, J Lachica, SN Pressey, SC Foti, M Al Shahrani… - Acta neuropathologica …, 2022 - Springer
Background The molecular drivers of early sporadic Parkinson’s disease (PD) remain
unclear, and the presence of widespread end stage pathology in late disease masks the …

[HTML][HTML] CB-RAF600E-1 exerts efficacy in vemurafenib-resistant and non-resistant-melanoma cells via dual inhibition of RAS/RAF/MEK/ERK and PI3K/Akt signaling …

M Al Shahrani, P Rajagopalan, M Abohassan… - Saudi Journal of …, 2022 - Elsevier
Mesfer Al Shahrani a , Prasanna Rajagopalan a b , Mohammad Abohassan a , Mohammad
Alshahrani … -1-one against human breast adenocarcinoma cell line by G2/M cell cycle arrest …

Electrochemical and optical properties of tellurium dioxide (TeO2) nanoparticles

…, NS Alsaiari, M Danish, AM Alshahrani… - International Journal of …, 2021 - Elsevier
Herein, a facile hydrothermal method was used for the preparation of nanostructured TeO 2
. Different techniques (X-ray diffraction, transmission electron microscope, and scanning …

[HTML][HTML] Synergistic efficacies of thymoquinone and standard antibiotics against multi-drug resistant isolates

…, M Al Shahrani, A Saif, MY Alshahrani… - Saudi Medical …, 2021 - ncbi.nlm.nih.gov
Objectives: To explore the antibacterial activity of thymoquinone (TQ), a quinone extracted
from Nigella sativa. Methods: This study was conducted from May 2019 to March 2020 at the …

Insilco and Invitro approaches identify novel dual PI3K/AKT pathway inhibitors to control acute myeloid leukemia cell proliferations

M Abohassan, M Alshahrani, MY Alshahrani… - Medical Oncology, 2022 - Springer
Acute myeloid leukemia (AML) is characterized by disruption of intracellular signaling due to
aberration of extracellular signaling pathways, namely PI3K/AKT cascade, by dysregulating …

[HTML][HTML] Impact of male obesity on semen quality and serum sex hormones

…, M Al-Shahrani, M Al-Sunaidi, M Almushait… - Advances in …, 2011 - hindawi.com
Introduction. To investigate the association of high Body Mass Index (BMI) with semen
parameters and reproductive hormones in men of reproductive age. Setting. The Saudi Center for …