Lipid‐lowering drugs, especially 3‐hydroxy‐3‐methylglutaryl–coenzyme A inhibitors (statins),
are widely used in the treatment and prevention of atherosclerotic disease. The benefits of …

Membrane transporters are now recognized as important determinants of the transmembrane
passage of drugs. Organic anion transporting polypeptides (OATP) form a family of influx …

The antituberculosis drug rifampicin (rifampin) induces a number of drug-metabolising enzymes,
having the greatest effects on the expression of cytochrome P450 (CYP) 3A4 in the liver …

The importance of membrane transporters for drug pharmacokinetics has been increasingly
recognized during the last decade. Organic anion transporting polypeptide 1B1 (OATP1B1) …

Methods Four healthy volunteers with the homozygous SLCO1B1 c. 521CC genotype, 12
with the heterozygous c. 521TC genotype and 16 with the homozygous c. 521TT genotype (…

This study aimed to characterize possible relationships between polymorphisms in the drug
transporter genes organic anion transporting polypeptide-C (OATP-C, SLCO1B1), OATP-B (…

Background and Objective A large interindividual variability exists in the plasma
concentrations of repaglinide. Our aim was to investigate possible associations between the …

Thirty‐two healthy volunteers with different SLCO1B1 genotypes ingested a 20 mg dose of
atorvastatin and 10 mg dose of rosuvastatin with a washout period of 1 week. Subjects with …

Statins reduce cholesterol, prevent cardiovascular disease, and are among the most
commonly prescribed medications in the world. Statin‐associated musculoskeletal symptoms (…

Simvastatin is among the most commonly used prescription medications for cholesterol
reduction. A single coding single‐nucleotide polymorphism, rs4149056T>C, in SLCO1B1 …