User profiles for Mohammad A. Alfhili

Mohammad A. Alfhili

Assistant Professor, King Saud University
Verified email at ksu.edu.sa
Cited by 656

[HTML][HTML] Triclosan: an update on biochemical and molecular mechanisms

MA Alfhili, MH Lee - Oxidative medicine and cellular longevity, 2019 - hindawi.com
Triclosan (TCS) is a synthetic, chlorinated phenolic antimicrobial agent commonly used in
commercial and healthcare products. Items made with TCS include soaps, deodorants, …

[HTML][HTML] Molecular mechanisms and pathophysiological significance of eryptosis

SA Alghareeb, MA Alfhili, S Fatima - International Journal of Molecular …, 2023 - mdpi.com
Despite lacking the central apoptotic machinery, senescent or damaged RBCs can undergo
an unusual apoptosis-like cell death, termed eryptosis. This premature death can be caused …

[HTML][HTML] Antioxidant, Anti-Proliferative Activity and Chemical Fingerprinting of Centaurea calcitrapa against Breast Cancer Cells and Molecular Docking of Caspase-3

MAM Aboul-Soud, H Ennaji, A Kumar, MA Alfhili, A Bari… - Antioxidants, 2022 - mdpi.com
Centaurea calcitrapa has been intensively utilized in ethnomedicinal practices as a natural
therapeutic recipe to cure various ailments. The current study aimed to chemically …

[HTML][HTML] Stimulation of hemolysis and eryptosis by α-Mangostin through Rac1 GTPase and oxidative injury in human red blood cells

SA Alghareeb, J Alsughayyir, MA Alfhili - Molecules, 2023 - mdpi.com
Background: Chemotherapy-related anemia is prevalent in up to 75% of patients, which
may arise due to hemolysis and eryptosis. Alpha-mangostin (α-MG) is a polyphenolic …

Metabolic exhaustion and casein kinase 1α drive deguelin-induced premature red blood cell death

MA Alfhili, J Alsughayyir - Xenobiotica, 2023 - Taylor & Francis
Deguelin (DGN), a retinoid isolated from many plants, exhibits a potent anticancer activity
against a wide spectrum of tumour cells. There is a dearth of evidence, however, regarding the …

[HTML][HTML] Lauric acid, a dietary saturated medium-chain fatty acid, elicits calcium-dependent eryptosis

MA Alfhili, GS Aljuraiban - Cells, 2021 - mdpi.com
Cardiovascular diseases (CVD) are a leading cause of mortality worldwide, and dietary
habits represent a major risk factor for dyslipidemia; a hallmark of CVD. Saturated fatty acids …

Disruption of erythrocyte membrane asymmetry by triclosan is preceded by calcium dysregulation and p38 MAPK and RIP1 stimulation

MA Alfhili, DA Weidner, MH Lee - Chemosphere, 2019 - Elsevier
Triclosan (TCS) is a broad-spectrum antimicrobial used in personal care products, household
items, and medical devices. Owing to its apoptotic potential against tumor cells, TCS has …

Thymoquinone attenuates oxidative stress of kidney mitochondria and exerts nephroprotective effects in oxonic acid‐induced hyperuricemia rats

AA Dera, P Rajagopalan, MA Alfhili, I Ahmed… - Biofactors, 2020 - Wiley Online Library
Background Recent studies indicate hyperuricemia as an aggravating factor for kidney
diseases progression. Basic research for novel agents to reduce hyperuricemia and kidney …

[HTML][HTML] Triclosan Disrupts SKN-1/Nrf2-Mediated Oxidative Stress Response in C. elegans and Human Mesenchymal Stem Cells

…, Y Choi, DS Cha, P Zhang, SM Choi, MA Alfhili… - Scientific reports, 2017 - nature.com
Triclosan (TCS), an antimicrobial chemical with potential endocrine-disrupting properties,
may pose a risk to early embryonic development and cellular homeostasis during adulthood. …

[HTML][HTML] Monocyte–Lymphocyte Ratio and Dysglycemia: A Retrospective, Cross-Sectional Study of the Saudi Population

MA Alfhili, J Alsughayyir, AM Basudan, R Alsubki… - Healthcare, 2022 - mdpi.com
Background: Abnormalities in fasting blood glucose (FBG) resulting in hypoglycemia (OG),
impaired fasting glycemia (IFG), or hyperglycemia (HG) arise from disordered metabolic …