In an effort to establish new candidates with improved antineoplastic, anti-HIV-1 and
antimicrobial activities we report here the synthesis and in vitro biological evaluation of various …

The synthesis of two groups of structure hybrids comprising basically the antipyrine moiety
attached to either polysubstituted thiazole or 2,5-disubstituted-1,3,4-thiadiazole counterparts …

The synthesis of a series of certain polymethoxy chalcones and some derived pyrazole,
pyrimidine, and thiazolopyrimidine ring structures is reported. Eleven compounds 4, 6, 9, 11, 14–…

Thirty thiazole compounds bearing chemotherapeutically-active pharmacophores were
synthesized and evaluated for their preliminary in vitro antimicrobial and anticancer activities. …

Two series of benzodioxole–pyrazole hybrids were synthesized and the IC 50 values for in
vitro inhibition of the enzymes cyclooxygenase 1/2 (COX‐1, COX‐2) and 5‐lipoxygenase (5‐…

In search of novel purine antimetabolites, a series of 8‐substituted methylxanthine derivatives
was prepared in order to explore their in vitro anticancer, anti‐HIV‐1 and antimicrobial …

Synthesis of twenty nine new 1,2,4-triazoles and some derived thiazolothiadiazoles (structurally-relevant
to some reported triazoles with anticancer and/or Cdc25A/B inhibitory activities) …

In an effort to etablish new candidates with improved antineoplastic, anti-HIV-1 and antimicrobial
activities, the synthesis of some new triazino and triazolo[4,3-e]purine derivatives is …

Most of cancer chemotherapeutics and chemopreventives exert their effects by triggering
apoptotic cell death. In this study, novel benzimidazole and benzothiazole derivatives have …

Diabetes mellitus (DM) is a chronic debilitating illness, and atherosclerotic changes are
inevitable and usually neglected during the follow-up of diabetic patients. Toll-like receptor 2 (…