Purpose: The molecular drivers of antitumor immunity in pancreatic ductal adenocarcinoma (PDAC)
are poorly understood, posing a major obstacle for the identification of patients …

Leptin is a multifunctional adipose-derived cytokines that play a critical role in bodyweight
homeostasis and energy balance. Recently, leptin and leptin receptor dysreulation have been …

The inhibitor of apoptosis protein (IAP) family member X‐linked inhibitor of apoptosis protein
(XIAP) is essential for cell survival in lymphoma. However, the role of XIAP overexpression …

We investigated the role of leptin receptor (Ob-R) and its relationship with phosphatidylinositol
3-kinase (PI3K)/AKT activation in colorectal carcinomas (CRCs) tissues followed by in …

Activated B-cell lymphoma (ABC), one of the three subtypes of Diffuse Large B-cell Lymphoma
(DLBCL) has the worst survival rate after upfront chemotherapy and is characterized by …

Objective: To document the incidence and role of p53 and DNA mismatch repair proteins in
colorectal carcinomas, and to evaluate the relative frequency of major molecular pathways in …

Objective To evaluate the overall incidence of microsatellite instability (MSI), hereditary non
polyposis colorectal cancer, and tumor supressor gene (TP53) mutations in Saudi colorectal …

Esophageal cancer is one of the most aggressive malignant gastrointestinal tumors and the
majority of esophageal cancers are squamous cell carcinoma (ESCC) or adenocarcinoma (…

Phosphotidylinositol 3′-kinases are lipid kinases that regulate signaling pathways involved
in cell proliferation, adhesion, survival, motility, and are implicated to play an important …

S-phase kinase-associated protein 2 (SKP-2) is a proto-oncogene that has been shown to be
expressed in a number of tumors. A number of studies have shown that SKP-2 plays a role …