Severe or therapy-resistant asthma is increasingly recognised as a major unmet need. A
Task Force, supported by the European Respiratory Society and American Thoracic Society, …

Background Interleukin-5 (IL-5) is essential for the formation of eosinophils, which are thought
to have a major role in the pathogenesis of asthma and other allergic diseases. We aimed …

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection carries
a substantial risk of severe and prolonged illness; treatment options are currently limited. …

Materials and Methods Subjects The details of the subjects are shown in Table 1. There
were all nonsmokers, and the asthmatics used only inhaled medication. Five days prior to …

In order to investigate the relationship between airways inflammation and disease severity,
and improve the understanding of persistent asthma, 74 asthmatics, with disease severity …

IgE plays an important role in allergic asthma. We hypothesized that reducing IgE in the
airway mucosa would reduce airway inflammation. Forty-five patients with mild to moderate …

BACKGROUND: Asthma is a complex disease involving gene and environment interactions.
Although atopy is a strong predisposing risk factor for asthma, local tissue susceptibilities …

The effect of inhaled corticosteroid therapy on airway mucosal inflammation was investigated
in 10 symptomatic atopic asthmatic patients treated with inhaled albuterol and whose …

As physiologic and autopsy evidence suggests that peripheral airways and parenchyma are
involved in asthma, we hypothesized that significant alveolar tissue inflammation is present …

Airway wall remodeling is an established pathological feature in asthma. Its causes are not
well understood, but one mediator of potential relevance is transforming growth factor-beta 1 (…