Cancer is one of the leading health hazards and the prominent cause of death in the world.
A number of anticancer agents are currently in clinical practice and used for treatment of …

3-Thiazole is one of the most important scaffolds in heterocyclic chemistry and drug design
and discovery. It is widely found in diverse pharmacologically active substances and in some …

The indole scaffold is one of the most widespread heterocycles in the naturally occurring
and synthetic bioactive compounds including anticancer agents. Due to its biodiversity and …

Nowadays, the importance of sustainable development has persuaded the supply chain
managers to shift their network to sustainable supply. This research develops a multi-objective …

A variety of (Z)-[(2H-chromen-3-yl)methylene]azolidinones 6a–t bearing thiazolidine-2,4-dione,
rhodanine or hydantoin scaffolds were designed and synthesized as potential anticancer …

Chroman-4-one scaffold is a privileged structure in heterocyclic chemistry and drug discovery.
Also, chroman-4-ones are important intermediates and interesting building blocks in …

A series of N-(5-benzylthio-1,3,4-thiadiazol-2-yl) and N-(5-benzylsulfonyl-1,3,4-thiadiazol-2-yl)
derivatives of piperazinyl quinolones was synthesized and evaluated for antibacterial …

Vinyl sulfone with electrophilic character is not only a versatile building block for various
organic transformations but also is a key structural unit in a large number of biologically active …

2-Hydroxyphenacyl azole and 2-hydroxyphenacyl azolium compounds have been described
as a new class of azole antifungals. Most target compounds showed significant in vitro …

Some novel coumarin-3-carboxamide derivatives linked to N-benzylpiperidine scaffold
were synthesized and evaluated as acetylcholinesterase (AChE) and butyrylcholinesterase (…