Selection of Fluorescent, Bioluminescent, and Radioactive Tracers to Accurately Reflect Extracellular Vesicle Biodistribution in Vivo
…, AM Silva, J Tzu-Wen Wang, J Rak, KT Al-Jamal… - ACS …, 2021 - ACS Publications
The ability to track extracellular vesicles (EVs) in vivo without influencing their biodistribution
is a key requirement for their successful development as drug delivery vehicles and …
is a key requirement for their successful development as drug delivery vehicles and …
[HTML][HTML] Activation of STAT and SMAD signaling induces hepcidin re-expression as a therapeutic target for β-Thalassemia patients
Iron homeostasis is regulated by hepcidin, a hepatic hormone that controls dietary iron
absorption and plasma iron concentration. Hepcidin binds to the only known iron export protein, …
absorption and plasma iron concentration. Hepcidin binds to the only known iron export protein, …
Efficacy and Outcome Measurement of iFactor/ABM/P-15 in Lumbar Spine Surgery: A Systematic Review
S Hasan, M Al-Jamal, A Miller… - Global spine …, 2023 - journals.sagepub.com
Study Design Systematic Review. Objectives To determine the efficacy and overall outcomes
of iFactor/ABM/P-15 following lumbar spine surgery. Methods We performed a search of …
of iFactor/ABM/P-15 following lumbar spine surgery. Methods We performed a search of …
[HTML][HTML] Gene expression profiling and protein analysis reveal suppression of the C-Myc oncogene and inhibition JAK/STAT and PI3K/AKT/mTOR signaling by …
Overexpression of c-Myc plays an essential role in leukemogenesis and drug resistance,
making c-Myc an attractive target for cancer therapy. However, targeting c-Myc directly is …
making c-Myc an attractive target for cancer therapy. However, targeting c-Myc directly is …
[HTML][HTML] Thymoquinone induces downregulation of BCR-ABL/JAK/STAT pathway and apoptosis in K562 leukemia cells
Objective: BCR ABL oncogene encodes the BCR-ABL chimeric protein, which is a constitutively
activated non-receptor tyrosine kinase. The BCR-ABL oncoprotein is a key molecular …
activated non-receptor tyrosine kinase. The BCR-ABL oncoprotein is a key molecular …
[HTML][HTML] Thymoquinone Inhibits Growth of Acute Myeloid Leukemia Cells through Reversal SHP-1 and SOCS-3 Hypermethylation: In Vitro and In Silico Evaluation
Epigenetic silencing of tumor suppressor genes (TSGs) plays an essential role in cancer
pathogenesis, including acute myeloid leukemia (AML). All of SHP-1, SOCS-1, and SOCS-3 are …
pathogenesis, including acute myeloid leukemia (AML). All of SHP-1, SOCS-1, and SOCS-3 are …
[HTML][HTML] Thymoquinone inhibits JAK/STAT and PI3K/Akt/mTOR signaling pathways in MV4-11 and K562 myeloid leukemia cells
Constitutive activation of Janus tyrosine kinase-signal transducer and activator of transcription
(JAK/STAT) and Phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/…
(JAK/STAT) and Phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/…
[HTML][HTML] Thymoquinone Enhances Apoptosis of K562 Chronic Myeloid Leukemia Cells through Hypomethylation of SHP-1 and Inhibition of JAK/STAT Signaling …
The epigenetic silencing of tumor suppressor genes (TSGs) is critical in the development of
chronic myeloid leukemia (CML). SHP-1 functions as a TSG and negatively regulates JAK/…
chronic myeloid leukemia (CML). SHP-1 functions as a TSG and negatively regulates JAK/…
[HTML][HTML] HBB gene mutations and their pathological impacts on HbE/β-Thalassaemia in Kuala Terengganu, Malaysia
…, AA Abd Rahman, AS Al-Wajeeh, HAN Al-Jamal - Diagnostics, 2023 - mdpi.com
Background: β-thalassaemia is a disorder caused by mutations in the β-globin gene,
leading to defective production of haemoglobins (Hb) and red blood cells (RBCs). It is …
leading to defective production of haemoglobins (Hb) and red blood cells (RBCs). It is …
Psychosocial burden on informal caregivers of patients with bipolar mood disorders
ES Saleh, Z Gomaa, R Al-Jamal… - Middle East Current …, 2013 - journals.lww.com
Objectives The aim of this study was to detect and measure the extent of psychosocial burden
and psychiatric morbidity among the caregivers of bipolar mood disorder patients and to …
and psychiatric morbidity among the caregivers of bipolar mood disorder patients and to …