Severe or therapy-resistant asthma is increasingly recognised as a major unmet need. A
Task Force, supported by the European Respiratory Society and American Thoracic Society, …

Although asthma has been considered as a single disease for years, recent studies have
increasingly focused on its heterogeneity. The characterization of this heterogeneity has …

Rationale: The Severe Asthma Research Program cohort includes subjects with persistent
asthma who have undergone detailed phenotypic characterization. Previous univariate …

Background: The assessment of asthma control is pivotal to the evaluation of treatment
response in individuals and in clinical trials. Previously, asthma control, severity, and …

Background Many patients with severe asthma require regular treatment with oral glucocorticoids
despite the use of high-dose inhaled therapy. However, the regular use of systemic …

… Correspondence and requests for reprints should be addressed to Sally E. Wenzel, MD,
National Jewish Medical and Research Center, 1400 Jackson St., Denver, CO 80206. …

It is increasingly clear that asthma is a complex disease made up of number of disease
variants with different underlying pathophysiologies. Limited knowledge of the mechanisms of …

The common disease asthma is probably not a single disease, but rather a complex of
multiple, separate syndromes that overlap. Although clinicians have recognised these different …

BACKGROUND: Severe asthma causes the majority of asthma morbidity. Understanding
mechanisms that contribute to the development of severe disease is important. OBJECTIVE: …

… Correspondence and requests for reprints should be addressed to Sally E. Wenzel, MD,
National Jewish Center for Immunology and Respiratory Medicine, 1400 Jackson St., J117, …