Peppermint (Mentha piperita L.) essential oil and its main components were assessed for
their ability to interfere with plant plasma membrane potentials. Tests were conducted on root …

We investigated the relative contribution of IL-6 and PGE2 directly induced by LPS and
indirectly induced via TNF, using in vivo and in vitro models in the mouse. In these models we …

Among nonsteroidal anti-inflammatory drugs (NSAIDs), 2-arylpropionic acids exist as a racemic
mixture of its enantiomeric forms, withS-enantiomers primarily responsible for inhibition …

We evaluated the efficacy of clodronate for treating active erosive osteoarthritis of the hand
and to compare it with hydroxychloroquine. Group A consisted of 24 patients treated for 24 …

Melatonin is an antioxidant. Since other antioxidants inhibit the production of tumor necrosis
factor (TNF) induced by lipopolysaccharide, we investigated its effect on TNF production in …

Urocortin (UCN) is a neuropeptide homologous with corticotropin-releasing factor (CRF),
which has anti-inflammatory activities not all mediated by corticosteroids. In mice, UCN (1 μg/…

We evaluated the efficacy and safety of intramuscular clodronate (CLO) for the treatment of
active erosive osteoarthritis of the hand (EOA). Forty outpatients treated with anti-…

The mechanisms of interleukin-12 (IL-12) toxicity were studied in mice using a schedule (murine
rIL-12, 400 ng/mouse, intraperitoneally [IP] once daily for 5 days) that markedly reduced …

Glucocorticoids (GC) are known inhibitors of TNF production and are increased by endotoxin
(LPS) through a stimulation of the hypothalamus-pituitary-adrenal axis (HPAA), suggesting …

Chronic administration of cocaine produces sensitization to its behavioral effects in humans
and experimental animals. In the present study, rats treated with cocaine (10 mg/kg, ip) once …