Identification of nesfatin-1 as a satiety molecule in the hypothalamus

…, M Yamamoto, T Imaki, K Hashimoto, T Tsuchiya… - Nature, 2006 - nature.com
The brain hypothalamus contains certain secreted molecules that are important in
regulating feeding behaviour 1 , 2 , 3 . Here we show that nesfatin, corresponding to NEFA/…

Fasting concentrations of nesfatin‐1 are negatively correlated with body mass index in non‐obese males

T Tsuchiya, H Shimizu, M Yamada, A Osaki… - Clinical …, 2010 - Wiley Online Library
Background We recently identified a novel anorexigenic protein, nesfatin‐1, which is processed
from nesfatin/nucleobindin‐2 (NUCB2). However, the clinical importance of this protein …

Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles

…, T Saito, K Ohshima, M Sato, T Tsuchiya… - The Journal of cell …, 2005 - rupress.org
We have identified an unusual potential dual Akt/protein kinase B consensus phosphorylation
motif in the protein Synip (RxKxRS 97 xS 99 ). Surprisingly, serine 97 is not appreciably …

Linkage of calpain 10 to type 2 diabetes: the biological rationale

NJ Cox, MG Hayes, CA Roe, T Tsuchiya, GI Bell - Diabetes, 2004 - Am Diabetes Assoc
The follow-up studies to the original report of association of variation at calpain 10 (CAPN10)
with type 2 diabetes in the Mexican-American population of Starr County, Texas, …

Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses

T Tsuchiya, PEH Schwarz, L del Bosque-Plata… - Molecular genetics and …, 2006 - Elsevier
We conducted pooled and meta-analyses of the association of the calpain-10 gene (CAPN10)
polymorphisms SNP-43, Indel-19 and SNP-63 individually and as haplotypes with type 2 …

Insulin promoter factor-1 mutations and diabetes in Trinidad: identification of a novel diabetes-associated mutation (E224K) in an Indo-Trinidadian family

…, S Teelucksingh, T Tsuchiya… - The journal of …, 2004 - academic.oup.com
This study investigated the prevalence of insulin promoter factor-1(IPF-1) mutations in familial
early-onset diabetes mellitus in Trinidad. We screened 264 unrelated subjects with type 2 …

THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation

…, A Ozawa, N Shibusawa, T Tsuchiya… - Molecular …, 2013 - academic.oup.com
Using yeast two-hybrid screen, we previously isolated HELZ2 (helicase with zinc finger 2,
transcriptional coactivator) that functions as a coregulator of peroxisome proliferator-activated …

Association of the calpain-10 gene with type 2 diabetes mellitus in a Mexican population

…, F Gómez-Pérez, CL Hanis, T Tsuchiya… - Molecular Genetics and …, 2004 - Elsevier
Variation in the calpain-10 gene (CAPN10) has been associated with risk of type 2 diabetes
in the Mexican American population of Starr County, Texas. We typed five polymorphisms in …

[HTML][HTML] Isolated adrenocorticotropic hormone deficiency and severe hypercalcemia after destructive thyroiditis in a patient on nivolumab therapy with a malignant …

…, T Suzuki, R Naruse, K Hara, T Tsuchiya… - Journal of Clinical …, 2018 - ncbi.nlm.nih.gov
We describe a 58-year-old man with a malignant melanoma metastasis to the liver. After
initiation of nivolumab therapy, he developed destructive thyroiditis and subsequently …

Chop‐deficient Mice Showed Increased Adiposity But No Glucose Intolerance

Y Ariyama, H Shimizu, T Satoh, T Tsuchiya, S Okada… - …, 2007 - Wiley Online Library
Objective: CCAAT/enhancer binding protein (C/EBP) homologous protein (CHOP)‐10/growth
arrest and DNA damage 153 is a dominant‐negative member of the C/EBP transcription …