1. The metabolism of the broad-spectrum antiviral drug ribavirin was examined in intact
human erythrocytes, cultured skin fibroblasts and EBV-transformed lymphoblasts. At an …

Four unrelated patients are described with a syndrome that included developmental delay,
seizures, ataxia, recurrent infections, severe language deficit, and an unusual behavioral …

Although the exact prevalence of metabolic abnormalities in autism spectrum disorders is
unknown, several metabolic defects have been associated with autistic symptoms. These …

A subclass of patients with classic infantile autism have uric acid excretion which is >2 SDs
above the normal mean. These hyperuricosuric autistic individuals may comprise approx. 20…

A simple reversed-phase high-performance liquid chromatography (HPLC) method for the
simultaneous determination of caffeine and paraxanthine in human serum is described. …

The effects of three inhibitors of inosine monophosphate (IMP) dehydrogenase on a human
erythroleukemic cell line, K562, were studied. Following incubation with these inhibitors, …

The Lesch—Nyhan disease is caused by an almost complete lack of the enzyme
hypoxanthine-guanine phosphoribosyl-transferase (HPRT). Partial HPRT-deficiency, associated with …

A fast, simple, and cost-effective HPLC method for the quantitation of the antiviral drug
ganciclovir is described. The serum samples are extracted with perchloric acid and neutralized …

Since the discovery that a deficiency of the enzyme hypoxanthine-guanine
phosphoribosyltransferase (HPRT) was responsible for the Lesch-Nyhan syndrome (1, 2), a number …

A detailed study of the inhibition of DR And TR in the SkLu-1 line of human lung adenocarcinoma
has shown that TR significantly inhibits this tumor line, probably via inhibition of IMP …