Identification of c-MYC as a Target of the APC Pathway
TC He, AB Sparks, C Rago, H Hermeking, L Zawel… - Science, 1998 - science.org
The adenomatous polyposis coli gene (APC) is a tumor suppressor gene that is inactivated
in most colorectal cancers. Mutations of APC cause aberrant accumulation of β-catenin, …
in most colorectal cancers. Mutations of APC cause aberrant accumulation of β-catenin, …
A simplified system for generating recombinant adenoviruses
Recombinant adenoviruses provide a versatile system for gene expression studies and
therapeutic applications. We report herein a strategy that simplifies the generation and …
therapeutic applications. We report herein a strategy that simplifies the generation and …
[PDF][PDF] 14-3-3σ is a p53-regulated inhibitor of G2/M progression
Exposure of colorectal cancer (CRC) cells to ionizing radiation results in a cell-cycle arrest in
G1 and G2. The G1 arrest is due to p53-mediated induction of the cyclin-dependent kinase …
G1 and G2. The G1 arrest is due to p53-mediated induction of the cyclin-dependent kinase …
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
…, AP Grollman, TC He, Y He… - Proceedings of the …, 2013 - National Acad Sciences
Malignant cells, like all actively growing cells, must maintain their telomeres, but genetic
mechanisms responsible for telomere maintenance in tumors have only recently been …
mechanisms responsible for telomere maintenance in tumors have only recently been …
[HTML][HTML] PPARδ is an APC-regulated target of nonsteroidal anti-inflammatory drugs
PPARδ was identified as a target of APC through the analysis of global gene expression
profiles in human colorectal cancer (CRC) cells. PPARδ expression was elevated in CRCs and …
profiles in human colorectal cancer (CRC) cells. PPARδ expression was elevated in CRCs and …
Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs)
…, P Vanichakarn, JP Szatkowski, JY Park, TC He - JBJS, 2003 - journals.lww.com
Background: Bone morphogenic proteins (BMPs) are known to promote osteogenesis, and
clinical trials are currently underway to evaluate the ability of certain BMPs to promote fracture…
clinical trials are currently underway to evaluate the ability of certain BMPs to promote fracture…
[HTML][HTML] Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis
As the most commonly occurring cancer in women worldwide, breast cancer poses a
formidable public health challenge on a global scale. Breast cancer consists of a group of …
formidable public health challenge on a global scale. Breast cancer consists of a group of …
A protocol for rapid generation of recombinant adenoviruses using the AdEasy system
Recombinant adenoviruses provide a versatile system for gene expression studies and
therapeutic applications. We have developed an approach that simplifies the generation and …
therapeutic applications. We have developed an approach that simplifies the generation and …
Analysis of human transcriptomes
…, BP Cook, MR Dufault, AT Ferguson, Y Gao, TC He… - Nature …, 1999 - nature.com
How many human genes are expressed ubiquitously, in all human tissues, and how many
are expressed in tissue-specific patterns? To answer these fundamental questions in …
are expressed in tissue-specific patterns? To answer these fundamental questions in …
[HTML][HTML] The first identification of lysine malonylation substrates and its regulatory enzyme
Protein post-translational modifications (PTMs) at the lysine residue, such as lysine methylation,
acetylation, and ubiquitination, are diverse, abundant, and dynamic. They play a key …
acetylation, and ubiquitination, are diverse, abundant, and dynamic. They play a key …