Small molecule inhibitor of nicotinamide N-methyltransferase shows anti-proliferative activity in HeLa cells
The anti-proliferative effects of 5-methylquinolinium (5MQ) of nicotinamide N-methyltransferase
(NNMT) have not been previously investigated on a cervical cancer cell line. NNMT is a …
(NNMT) have not been previously investigated on a cervical cancer cell line. NNMT is a …
[HTML][HTML] The effect of the top 20 Alzheimer disease risk genes on gray-matter density and FDG PET brain metabolism
Introduction We analyzed the effects of the top 20 Alzheimer disease (AD) risk genes on
gray-matter density (GMD) and metabolism. Methods We ran stepwise linear regression …
gray-matter density (GMD) and metabolism. Methods We ran stepwise linear regression …
Associations of the top 20 Alzheimer disease risk variants with brain amyloidosis
Importance Late-onset Alzheimer disease (AD) is highly heritable. Genome-wide association
studies have identified more than 20 AD risk genes. The precise mechanism through which …
studies have identified more than 20 AD risk genes. The precise mechanism through which …
Effects of fentanyl on pancreatic cancer cell proliferation and cancer stem cell differentiation
Pancreatic cancer is one of the most aggressive cancer due to the late diagnosis and failure
to respond to the treatment despite advances in tumor biology and the development of new …
to respond to the treatment despite advances in tumor biology and the development of new …
[HTML][HTML] Neurodegenerative changes in early-and late-onset cognitive impairment with and without brain amyloidosis
Background A substantial number of patients clinically diagnosed with Alzheimer’s disease
do not harbor amyloid pathology. We analyzed the presence and extent of tau deposition …
do not harbor amyloid pathology. We analyzed the presence and extent of tau deposition …
In vitro antifungal and antibiofilm activities of novel sulfonyl hydrazone derivatives against Candida spp.
Background The aim of this study was to investigate the antifungal and antibiofilm activity of
the new sulfonyl hydrazones compound derived from sulphonamides. Methods In this study, …
the new sulfonyl hydrazones compound derived from sulphonamides. Methods In this study, …
Effective anticancer agents based-on two Pillar [5] arene derivatives for pancreas cancer cell lines: synthesis, apoptotic effect, caspase pathway
This study aimed to evaluate the possible anticancer effects of two different pillar[5]arene
derivatives (5Q-[P5] and 10Q-P[5]) on two different pancreatic cancer cell lines in vitro. For this …
derivatives (5Q-[P5] and 10Q-P[5]) on two different pancreatic cancer cell lines in vitro. For this …
Investigation of the effects of the toll-like receptor 4 pathway on immune checkpoint vista in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is one of the most common malignant tumors of
the pancreas. Preclinical studies show that it evades the immune system with immune …
the pancreas. Preclinical studies show that it evades the immune system with immune …
Extractions of aerial parts of Hippomarathrum scabrum with conventional and green methodologies: Chemical profiling, antioxidant, enzyme inhibition, and anti …
Hippomarathrum scabrum L. is an endemic medicinal plant in Turkey; however, there have
been few studies investigating the phytochemistry and biological properties of these plants …
been few studies investigating the phytochemistry and biological properties of these plants …
Examining a Preclinical Alzheimers Cognitive Composite for Telehealth Administration, the tPACC, for Reliability between In-Person and Remote Cognitive Testing …
T Duran, SA Gaussoin, LA Latham, MM Rundle… - medRxiv, 2023 - medrxiv.org
INTRODUCTION: We defined a telehealth preclinical Alzheimers cognitive composite (tPACC)
derived from remotely administered cognitive assessments and examined its relationship …
derived from remotely administered cognitive assessments and examined its relationship …