Objective To study the epidemiology of colorectal cancer in Qatar and compare it with other
parts of the world. To collect demographic data on colorectal cancer in Qatar (age and sex …

Background The mechanism of tumor immune escape and progression in colorectal cancer
(CRC) is widely investigated in-vitro to help understand and identify agents that might play a …

Targeting the programmed cell death protein-1 (PD-1)/PD-1 ligand (PD-L1) pathway has
been shown to enhance T cell-mediated antitumor immunity. Clinical responses are limited to …

Background Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related
morbidity and mortality worldwide. Immune checkpoint inhibitors (ICIs) including anti-PD-1 and …

Immune checkpoint inhibitors (ICIs) including anti-PD-1 and anti-PD-L1 antibodies, have
significantly changed the treatment outcomes of NSCLC patients with better overall survival. …

… writing, Final approval of manuscript, Karama Makni Maalej: Manuscript writing, Final
approval of manuscript, Ussama Al Homsi: Manuscript writing, Final approval of manuscript. …

Breast cancer is the leading cause of death in women. Prognosis of breast cancer is often
pessimistic because the tumors are prone to metastasizing to the bone, brain, and lung. The …

The advent of personalised medicine promises a deeper understanding of mechanisms and
therefore therapies. However, the connection between genomic sequences and clinical …

Immune checkpoint inhibitors (ICIs) have been approved as first or second line therapy in a
large group of cancers. However, the observation of potentially long-lasting responses was …

Background There is limited data on the predictive biomarkers of response to immune
checkpoint blockade (ICB) treatment of non-small cell lung cancer (NSCLC) patients. The main …