Chimeric antigen receptor (CAR)-T cell therapy has been shown to be an effective treatment
for hematological tumors, but the treatment of solid tumors still lacks effectiveness. In the …

The essential roles of microglia in maintaining homeostasis in the healthy brain and contributing
to neuropathology are well documented. Emerging evidence suggests that epigenetic …

Osteoarthritis (OA), the most ubiquitous degenerative disease affecting the entire joint, is
characterized by cartilage degradation and synovial inflammation. Although the pathogenesis …

Fibroblast-like synoviocytes (FLS) and macrophage-like synoviocytes (MLS) are the two main
cellular components of the synovium. It has been widely reported that FLS and MLS play …

The plant extract “total glucosides of peony” (TGP) constitutes a mixture of glycosides that is
isolated from the roots of the well-known traditional Chinese herb Paeonia lactiflora Pall. …

The ontogeny of macrophages in most organ/tissues in human body has been proven. Due
to the limited number and inaccessibility of synovial macrophages (SM), the origin of SM has …

Objectives To uncover the function and underlying mechanism of an essential transcriptional
factor, PU.1, in the development of rheumatoid arthritis (RA). Methods The expression and …

Background The chimeric antigen receptor (CAR)-T therapy has a limited therapeutic effect
on solid tumors owing to the limited CAR-T cell infiltration into solid tumors and the …

The ontogeny of macrophages in most organs has already been established. Owing to the
limited number and inaccessibility of synovial macrophages (SMs), the origin of SMs has not …

Rheumatoid arthritis (RA) is a multisystemic and inflammatory autoimmune disease characterized
by joint destruction. The C–C motif chemokine receptor 2 (CCR2) is mainly expressed …