[HTML][HTML] Isoliquiritigenin prevents Doxorubicin-induced hepatic damage in rats by upregulating and activating SIRT1

WH Al-Qahtani, GM Alshammari, JS Ajarem… - Biomedicine & …, 2022 - Elsevier
This study evaluated if the hepatic protective effect of Isoliquiritigenin (ISL) against doxorubicin
(DOX)-treated rats involves upregulating sirtuin-1 (SIRT1) signaling. Adult male was …

[HTML][HTML] The protective effect of isoliquiritigenin against doxorubicin-induced nephropathy in rats entails activation of Nrf2 signaling as one key mechanism

WH Al-Qahtani, GM Alshammari… - Journal of King Saud …, 2022 - Elsevier
Objectives This study aimed to evaluate if the protective effect of Isoliquiritigenin (ISL) against
doxorubicin-induced nephropathy in rats entails activation of Nrf2 signaling. Methods Adult …

[HTML][HTML] Quercetin alleviates cadmium chloride-induced renal damage in rats by suppressing endoplasmic reticulum stress through SIRT1-dependent deacetylation of …

GM Alshammari, WH Al-Qahtani, NA AlFaris… - Biomedicine & …, 2021 - Elsevier
Endoplasmic reticulum (ER) stress plays a key role in cadmium chloride (CdCl2)-induced
nephrotoxicity. Sirtuin-1 (SIRT1) is a potent inhibitor of ER stress. In this study, we examined …

Quercetin prevents cadmium chloride‐induced hepatic steatosis and fibrosis by downregulating the transcription of miR‐21

GM Alshammari, WH AlQahtani, NA AlFaris… - …, 2021 - Wiley Online Library
This study investigated if cadmium chloride (CdCl 2 )‐induced hepatic steatosis and fibrosis
and the protective effect of quercetin (QUR) are mediated modulating the activity of miR‐21, …

Melatonin priming as a promising approach to improve biomass accumulation and the nutritional values of Chenopodium quinoa sprouts: A genotype-based study

…, MK Okla, ZK Abbas, WH Al-Qahtani, RS Yehia… - Scientia …, 2022 - Elsevier
Increasing the production of horticultural crops is one of the most important challenges
worldwide. Seed priming is a promising agricultural procedure for supporting growth and quality …

[HTML][HTML] Quercetin improves the impairment in memory function and attenuates hippocampal damage in cadmium chloride-intoxicated male rats by suppressing …

GM Alshammari, WH Al-Qahtani… - Journal of Functional …, 2021 - Elsevier
This study examined if quercetin (QUR) prevents cadmium chloride (CdCl 2 )-induced
hippocampal neurotoxicity in male rats by activating sirtuin-1 (SIRT1). Rats were divided into …

[HTML][HTML] Association of toll-like receptor 3 single-nucleotide polymorphisms and hepatitis C virus infection

…, B Alshahrani, MN Al-Ahdal, AA Al-Qahtani - Journal of Immunology …, 2017 - hindawi.com
Toll-like receptor 3 (TLR3) plays a key role in innate immunity by recognizing pathogenic,
double-stranded RNAs. Thus, activation of TLR3 is a major factor in antiviral defense and …

[HTML][HTML] Magnitude and determinants of computer vision syndrome among college students at a Saudi university

…, YJ Al-Haqbani, NM Al-Qahtani… - Middle East African …, 2021 - journals.lww.com
PURPOSE: To review students’ perceived symptom-based computer vision syndrome (CVS)
and its determinants and to suggest preventive measures. METHODS: This cross-sectional …

[HTML][HTML] Social media and the orthopaedic surgeon: a mixed methods study

T Justinia, A Alyami, S Al-Qahtani… - Acta Informatica …, 2019 - ncbi.nlm.nih.gov
Aim: To assess the perceptions and usage of SM (SM) by OSs (OS) in Jeddah, Saudi Arabia,
and its impact on their profession, and to evaluate their level of awareness of the potential …

Clinical effectiveness of Liraglutide 3.0 mg and impact of weight loss in improving obesity‐related comorbid conditions in King Fahad Medical City, Kingdom of Saudi …

…, N AlFaris, AM Al Qahtani, M Shams, M Yahia - Clinical …, 2023 - Wiley Online Library
Obesity has emerged as one of the most challenging worldwide problems and, if left
untreated, can lead to major illnesses and consequences that can impair patients' health The …