User profiles for Yuan Zong

Yuan Zong

Southeast University
Verified email at seu.edu.cn
Cited by 3636

Prime genome editing in rice and wheat

Q Lin, Y Zong, C Xue, S Wang, S Jin, Z Zhu… - Nature …, 2020 - nature.com
Prime editors, which are CRISPR–Cas9 nickase (H840A)–reverse transcriptase fusions
programmed with prime editing guide RNAs (pegRNAs), can edit bases in mammalian cells …

Oxidative stress-mediated cytotoxicity and metabolism of T-2 toxin and deoxynivalenol in animals and humans: an update

…, LY Xiong, K Kuča, V Dohnal, XJ Zhang, ZH Yuan - Archives of …, 2014 - Springer
Trichothecenes are a large family of structurally related toxins mainly produced by Fusarium
genus. Among the trichothecenes, T-2 toxin and deoxynivalenol (DON) cause the most …

Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice

S Jin, Y Zong, Q Gao, Z Zhu, Y Wang, P Qin, C Liang… - Science, 2019 - science.org
Cytosine and adenine base editors (CBEs and ABEs) are promising new tools for achieving
the precise genetic changes required for disease treatment and trait improvement. However, …

An engineered prime editor with enhanced editing efficiency in plants

Y Zong, Y Liu, C Xue, B Li, X Li, Y Wang, J Li… - Nature …, 2022 - nature.com
Prime editing is a versatile genome-editing technology, but it suffers from low editing efficiency.
In the present study, we introduce optimized prime editors with substantially improved …

[HTML][HTML] Expanded base editing in rice and wheat using a Cas9-adenosine deaminase fusion

C Li, Y Zong, Y Wang, S Jin, D Zhang, Q Song… - Genome biology, 2018 - Springer
Nucleotide base editors in plants have been limited to conversion of cytosine to thymine.
Here, we describe a new plant adenine base editor based on an evolved tRNA adenosine …

[HTML][HTML] Efficient and transgene-free genome editing in wheat through transient expression of CRISPR/Cas9 DNA or RNA

Y Zhang, Z Liang, Y Zong, Y Wang, J Liu… - Nature …, 2016 - nature.com
Editing plant genomes is technically challenging in hard-to-transform plants and usually
involves transgenic intermediates, which causes regulatory concerns. Here we report two …

Precise base editing in rice, wheat and maize with a Cas9-cytidine deaminase fusion

Y Zong, Y Wang, C Li, R Zhang, K Chen, Y Ran… - Nature …, 2017 - nature.com
Targeted base editing in plants without the need for a foreign DNA donor or double-stranded
DNA cleavage would accelerate genome modification and breeding in a wide array of crops…

High-efficiency prime editing with optimized, paired pegRNAs in plants

Q Lin, S Jin, Y Zong, H Yu, Z Zhu, G Liu, L Kou… - Nature …, 2021 - nature.com
Prime editing (PE) applications are limited by low editing efficiency. Here we show that
designing prime binding sites with a melting temperature of 30 C leads to optimal performance in …

Spatial–temporal recurrent neural network for emotion recognition

T Zhang, W Zheng, Z Cui, Y Zong… - IEEE transactions on …, 2018 - ieeexplore.ieee.org
In this paper, we propose a novel deep learning framework, called spatial–temporal recurrent
neural network (STRNN), to integrate the feature learning from both spatial and temporal …

Gene replacements and insertions in rice by intron targeting using CRISPR–Cas9

J Li, X Meng, Y Zong, K Chen, H Zhang, J Liu, J Li… - Nature plants, 2016 - nature.com
Sequence-specific nucleases have been exploited to create targeted gene knockouts in
various plants 1, but replacing a fragment and even obtaining gene insertions at specific loci in …