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NewsThe Cochrane Library Newsalert
Open Access

Could a novel liver patch help treat and prevent liver disease?

Saudi Medical Journal July 2024, 45 (7) 751;
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JUNE 12, 2024 - As described in research published in the Biotechnology Journal, investigators have developed a novel patch that can help liver tissue regenerate.

The patch is a combination of decellularized liver matrix, a liver growth factor, and an anticoagulant. In lab tests with liver cells, the patch helped liver cells regain function after exposure to a toxin.

In rats, patches attached to the liver and gut promoted recovery from liver fibrosis, with notable decreases in scarring and inflammation.

“The decellularized liver matrix–based hepatic patch has demonstrated the ability to restore liver function and inhibit inflammation in fibrotic livers,” said corresponding author Yung-Te Hou, PhD, of National Taiwan University. “This approach shows great potential for treating various liver-related diseases, ranging from mild conditions such as fatty liver to severe conditions like liver cirrhosis.”

URL upon publication: https://onlinelibrary.wiley.com/doi/10.1002/biot.202300570

Full citation: “Fabrication of a decellularized liver matrix–based hepatic patch for the repair of CCl4-induced liver injury.” Ting-Yi Wu, Yi-Cheng Hsieh, Wei-Rong Yin, Kai-Yi Cheng, Yung-Te Hou. Biotechnol J; Published Online: 12 June 2024 (DOI: 10.1002/biot.202300570).

Copyright © 2019 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd., Reproduced with permission.

  • Copyright: © Saudi Medical Journal

This is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work.

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Saudi Medical Journal: 45 (7)
Saudi Medical Journal
Vol. 45, Issue 7
1 Jul 2024
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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