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Research ArticleOriginal Article
Open Access

The pattern of CagA and VacA proteins in Helicobacter pylori seropositive asymptomatic children in western Saudi Arabia

Soad M. Jaber
Saudi Medical Journal September 2005, 26 (9) 1372-1377;
Soad M. Jaber
Pediatrics Consultant, Department of Pediatrics, King Abdul-Aziz University Hospital, PO Box 17818, Jeddah 21494, Kingdom of Saudi Arabia. Tel.+966 505620044. Fax. +966 (2) 6444673. E-mail: [email protected]
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Abstract

OBJECTIVE: This study aimed to determine antibody prevalence to Helicobacter pylori (H. pylori) virulence factors CagA and VacA in asymptomatic H. pylori seropositive children in Jeddah, Kingdom of Saudi Arabia (KSA). The possibility of differences in antibodies response patterns was also investigated in relation to gender, nationality and age.

METHODS: Two hundred and twenty-four asymptomatic H. pylori seropositive children (mean age 9.3 ± 3.9 years; range, 1-14 years) were enrolled in this study from King Abdul-Aziz University and Maternity and Children's Hospitals, Jeddah, KSA, during the periods 2002-2003. The 35 kDa, CagA or VacA H. pylori antibodies were measured in the serum by immunoblot (Helico Blot 2) method.

RESULTS: Immunoblot assay yielded positive results in 215/224 seropositive asymptomatic children (96%). In those children, the prevalence of 35 kDa was 63.3%, VacA was 60%, CagA was 56.7% and for combined VacA and CagA antibodies was 45.6%. Prevalence of these bands did not show any difference between Saudi and non-Saudi children. Meanwhile, prevalence of 35 kDa, VacA, CagA, combined VacA and CagA antibodies were significantly elevated in males versus females (p<0.0001) and in children 10 years versus those in age groups 1-5 years and 6-9 years (p<0.0001).

CONCLUSION: This study showed high prevalence of H. pylori antibodies among asymptomatic children in Jeddah, KSA. The prevalence of antibodies against 35 kDa, CagA and VacA H. pylori antigens is higher in males and older children. The ELISA and immunoblot are non-invasive methods that were found to have adequate performance in pediatric population.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 26 (9)
Saudi Medical Journal
Vol. 26, Issue 9
1 Sep 2005
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The pattern of CagA and VacA proteins in Helicobacter pylori seropositive asymptomatic children in western Saudi Arabia
Soad M. Jaber
Saudi Medical Journal Sep 2005, 26 (9) 1372-1377;

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The pattern of CagA and VacA proteins in Helicobacter pylori seropositive asymptomatic children in western Saudi Arabia
Soad M. Jaber
Saudi Medical Journal Sep 2005, 26 (9) 1372-1377;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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