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Research ArticleOriginal Article
Open Access

Association of the polymorphism of codon 121 in the ecto-nucleotide pyrophosphatase/phosphodiesterase 1 gene with polycystic ovary syndrome in Chinese women

Yuhua Shi, Xuedong Sun, Zijiang Chen, Peng Zhang, Yueran Zhao and Li You
Saudi Medical Journal August 2008, 29 (8) 1119-1123;
Yuhua Shi
Center Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
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Xuedong Sun
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Zijiang Chen
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Peng Zhang
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Yueran Zhao
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Li You
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Abstract

OBJECTIVE: To determine the association of polymorphism of codon 121 in the ecto-nucleotide pyrophophastase/phosphodiesterase 1 (E-NPP1/PC-1) gene in Chinese women with polycystic ovary syndrome (PCOS).

METHODS: A total of 51 PCOS patients and 61 healthy women from the Chinese Han population from the Center Reproductive Medicine of Provincial Hospital affiliated to Shandong University from June 2005 to July 2006 were recruited for the determination of the polymorphism of the E-NPP1/PC-1 gene. Genomic DNA was extracted from peripheral blood monocytes of patients and controls, and genotyping of the gene was performed by using polymerase chain reaction, which was followed by sequencing.

RESULTS: The frequency of the 121Q allele was 13 and 18%, respectively, in PCOS patients and healthy women, while the frequency of the 121K allele was 87 and 82% in the 2 groups. There is no significant difference in the E-NPP1/PC-1 polymorphism between PCOS patients and healthy controls among Chinese Han women.

CONCLUSION: Ecto-nucleotide pyrophophastase/phosphodiesterase 1 polymorphism has no association with PCOS. Further studies are still needed to elucidate whether or not the E-NPP1/PC-1 gene has a functional role in PCOS.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 29 (8)
Saudi Medical Journal
Vol. 29, Issue 8
1 Aug 2008
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Association of the polymorphism of codon 121 in the ecto-nucleotide pyrophosphatase/phosphodiesterase 1 gene with polycystic ovary syndrome in Chinese women
Yuhua Shi, Xuedong Sun, Zijiang Chen, Peng Zhang, Yueran Zhao, Li You
Saudi Medical Journal Aug 2008, 29 (8) 1119-1123;

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Association of the polymorphism of codon 121 in the ecto-nucleotide pyrophosphatase/phosphodiesterase 1 gene with polycystic ovary syndrome in Chinese women
Yuhua Shi, Xuedong Sun, Zijiang Chen, Peng Zhang, Yueran Zhao, Li You
Saudi Medical Journal Aug 2008, 29 (8) 1119-1123;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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