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Research ArticleOriginal Article
Open Access

A randomized, double-blind, placebo-controlled trial of metformin treatment for weight gain associated with initiation of risperidone in children and adolescents

Soroor Arman, Mohammad R. Sadramely, Mortaza Nadi and Navid Koleini
Saudi Medical Journal August 2008, 29 (8) 1130-1134;
Soroor Arman
Department of Psychiatry, Isfahan University of Medical Sciences, Iran.
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Mohammad R. Sadramely
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Mortaza Nadi
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Navid Koleini
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Abstract

OBJECTIVE: To evaluate the effect of metformin treatment on the risperidone-induced body weight gain in patients.

METHODS: In a 12-weeks, double-blind, placebo controlled, randomized trial between October 2006 and October 2007 which was conducted in the Child and Adolescent Psychiatric Consultation Center of Isfahan University of Medical Sciences, 49 patients were entered the study with schizophrenia diagnosis. Then metformin (500 mg bid) or placebo was administrated with risperidone (6 mg) for the patients. Weight, height, and body mass index BMI were measured at the beginning, at 4 weeks, and at 12 weeks of the study. Changes in weight and BMI were evaluated by using repeated measures analysis of variance.

RESULTS: Seventeen patients were excluded from the study. Repeated measure analysis of variances showed a significant difference between weight and BMI in both metformin (p<0.001, p<0.015) and placebo group (p<0.013, p<0.005).

CONCLUSION: Metformin treatment did not show a significant effect to control the body weight of patients after 12 weeks.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 29 (8)
Saudi Medical Journal
Vol. 29, Issue 8
1 Aug 2008
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A randomized, double-blind, placebo-controlled trial of metformin treatment for weight gain associated with initiation of risperidone in children and adolescents
Soroor Arman, Mohammad R. Sadramely, Mortaza Nadi, Navid Koleini
Saudi Medical Journal Aug 2008, 29 (8) 1130-1134;

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A randomized, double-blind, placebo-controlled trial of metformin treatment for weight gain associated with initiation of risperidone in children and adolescents
Soroor Arman, Mohammad R. Sadramely, Mortaza Nadi, Navid Koleini
Saudi Medical Journal Aug 2008, 29 (8) 1130-1134;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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