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Research ArticleOriginal Article
Open Access

Thrombophilia-related genetic variations in patients with pulmonary embolism in the main Teaching Hospital in Jordan

Nathir M. Obeidat, Abdallah Awidi, Naef A. Sulaiman and Ilham B. Abu-Khader
Saudi Medical Journal July 2009, 30 (7) 921-925;
Nathir M. Obeidat
Department of Internal Medicine, Critical Care and Sleep Medicine, Jordan University Hospital, Amman 11942, Jordan. Tel. +962 (79) 5178552. E-mail: [email protected]
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Abdallah Awidi
Department of Internal Medicine, Critical Care and Sleep Medicine, Jordan University Hospital, Amman 11942, Jordan. Tel. +962 (79) 5178552. E-mail: [email protected]
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Naef A. Sulaiman
Department of Internal Medicine, Critical Care and Sleep Medicine, Jordan University Hospital, Amman 11942, Jordan. Tel. +962 (79) 5178552. E-mail: [email protected]
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Ilham B. Abu-Khader
Department of Internal Medicine, Critical Care and Sleep Medicine, Jordan University Hospital, Amman 11942, Jordan. Tel. +962 (79) 5178552. E-mail: [email protected]
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Abstract

OBJECTIVE: To study the frequency of Factor V Leiden (FVL), prothrombin gene mutation G20210A and methylenetetrahydrofolate reductase C677T in patients with acute pulmonary embolism (PE); and to investigate whether these factors are more frequent in patients who have no obvious risk factors for venous thrombo-embolism compared to those with obvious risk factors.

METHODS: A case-control study conducted at Jordan University Hospital, Amman, Jordan during the period 2005-2007. Compared 92 patients with acute PE to 99 normal subjects. All subjects were investigated for the 3 genetically related thrombophilic factors.

RESULTS: The frequency of these factors in patients were 22/92 (23.9%) FVL, 3/92 (3.3%) Factor II (FII) and 48/92 (52.2%) methylenetetrahydrofolate reductase (MTHFR). In the control group, FVL was 12/99 (12.1%), FII 0/99 (0%), and 53/99 (53.5%) MTHFR. There was a statistically significant difference between patients and controls for FVL (p=0.03), but no statistical significance for FII (p=0.10) and MTHFR (p=0.85). In patients with no obvious risk factors, the frequency of these factors were 8/29 (27.6%) FVL, 2/29 (6.9%) FII, and 14/29 (48.3%) for MTHFR compared to patients with obvious risk factors 14/63 (22.2%) for FVL, 1/63 (1.6%) FII, and 33/63 (52.3%) MTHFR.

CONCLUSION: The FVL is statistically more frequent in patients with PE compared to the control group, and the frequency of FVL, FII, and MTHFR is not significantly higher in patients with acute PE who have no obvious risk factors compared to those with obvious risk factors.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 30 (7)
Saudi Medical Journal
Vol. 30, Issue 7
1 Jul 2009
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Thrombophilia-related genetic variations in patients with pulmonary embolism in the main Teaching Hospital in Jordan
Nathir M. Obeidat, Abdallah Awidi, Naef A. Sulaiman, Ilham B. Abu-Khader
Saudi Medical Journal Jul 2009, 30 (7) 921-925;

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Thrombophilia-related genetic variations in patients with pulmonary embolism in the main Teaching Hospital in Jordan
Nathir M. Obeidat, Abdallah Awidi, Naef A. Sulaiman, Ilham B. Abu-Khader
Saudi Medical Journal Jul 2009, 30 (7) 921-925;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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