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Research ArticleOriginal Article
Open Access

Oxidative stress and nitric oxide deficiency in inflammation of chronic renal failure. Possible preventive role of L-arginine and multiple antioxidants

Aida A. Korish
Saudi Medical Journal September 2009, 30 (9) 1150-1157;
Aida A. Korish
Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia. Tel. +966 506282704. Fax. +966 (1) 4786798/4672567. E-mail: [email protected]
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Abstract

OBJECTIVE: To evaluate the effect of L-arginine and multiple antioxidants on the inflammatory cytokines level, renal functions, blood pressure and dyslipidemia in chronic renal failure (CRF) rats.

METHODS: This study was carried out between December 2007 and November 2008 in the Department of Physiology, Faculty of Medicine, King Saud University, Kingdom of Saudi Arabia. Chronic renal failure was induced in 40 rats by renal mass reduction (RMR) and 10 rats were sham operated. Renal mass reduction rats were treated for 12 weeks by L-arginine and/or a mixture of antioxidants (L-carnitine, Catechin, Vitamins E and C) and the effect of the treatments on plasma cytokines, soluble intercellular adhesion molecule-1 (sICAM-1), nitrate (NO2) and nitrites (NO3), lipid profile, blood pressure, and renal function was examined.

RESULTS: Chronic renal failure increased plasma Interleukin (IL)-1alpha, IL-1beta, IL-6, tumor necrosis factor-alpha, soluble intercellular adhesion molecule-1 (sICAM-1) levels and decreased anti-inflammatory cytokines IL-4 and 10 levels. In addition, hypertension, and dyslipidemia were found. L-arginine treatment improved kidney functions, decreased systolic blood pressure and decreased inflammatory cytokines levels. Antioxidants administration decreased inflammatory cytokines and sICAM-1 levels and increased IL-4 levels. Combined use of L-arginine and the antioxidants mixture were very effective in their tendency to recover normal values of kidney functions, plasma cytokines, sICAM-1, blood pressure, NO2/NO3, cholesterol and triglycerides concentrations.

CONCLUSION: Restoration of the pro-oxidant/ antioxidants balance with increased NO bio-availability counteracts inflammation, renal impairment and dyslipidemia in CRF. This may open new perspectives for the role of antioxidants and NO precursors in the treatment of uremia and its complications.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 30 (9)
Saudi Medical Journal
Vol. 30, Issue 9
1 Sep 2009
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Oxidative stress and nitric oxide deficiency in inflammation of chronic renal failure. Possible preventive role of L-arginine and multiple antioxidants
Aida A. Korish
Saudi Medical Journal Sep 2009, 30 (9) 1150-1157;

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Oxidative stress and nitric oxide deficiency in inflammation of chronic renal failure. Possible preventive role of L-arginine and multiple antioxidants
Aida A. Korish
Saudi Medical Journal Sep 2009, 30 (9) 1150-1157;
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© 2023 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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