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Research ArticleOriginal Article
Open Access

Hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient male newborns in Al-Ahsa, Saudi Arabia

Sameer Y. Al-Abdi, Taher A. Mousa, Maryam A. Al-Aamri, Najeeb G. Ul-Rahman and Ayman I. Abou-Mehrem
Saudi Medical Journal February 2010, 31 (2) 175-179;
Sameer Y. Al-Abdi
Department of Pediatrics, Neonatology Division, MC 315, King Abdulaziz Hospital for National Guard PO Box 2477, Al-Ahsa 31982, Kingdom of Saudi Arabia. Tel: +966 (3) 5910000 Ext. 33386. Fax: +966 (3) 5910000 Ext. 33844. E-mail: [email protected]
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Taher A. Mousa
Department of Pediatrics, Neonatology Division, MC 315, King Abdulaziz Hospital for National Guard PO Box 2477, Al-Ahsa 31982, Kingdom of Saudi Arabia. Tel: +966 (3) 5910000 Ext. 33386. Fax: +966 (3) 5910000 Ext. 33844. E-mail: [email protected]
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Maryam A. Al-Aamri
Department of Pediatrics, Neonatology Division, MC 315, King Abdulaziz Hospital for National Guard PO Box 2477, Al-Ahsa 31982, Kingdom of Saudi Arabia. Tel: +966 (3) 5910000 Ext. 33386. Fax: +966 (3) 5910000 Ext. 33844. E-mail: [email protected]
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Najeeb G. Ul-Rahman
Department of Pediatrics, Neonatology Division, MC 315, King Abdulaziz Hospital for National Guard PO Box 2477, Al-Ahsa 31982, Kingdom of Saudi Arabia. Tel: +966 (3) 5910000 Ext. 33386. Fax: +966 (3) 5910000 Ext. 33844. E-mail: [email protected]
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Ayman I. Abou-Mehrem
Department of Pediatrics, Neonatology Division, MC 315, King Abdulaziz Hospital for National Guard PO Box 2477, Al-Ahsa 31982, Kingdom of Saudi Arabia. Tel: +966 (3) 5910000 Ext. 33386. Fax: +966 (3) 5910000 Ext. 33844. E-mail: [email protected]
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Abstract

OBJECTIVE: To study the clinical and laboratory characteristics of hyperbilirubinemia in glucose-6-phosphate dehydrogenase (G6PD)-deficient male newborns from Al-Ahsa area (Ahsais).

METHODS: The medical records of inborn male infants at King Abdulaziz Hospital (KAH) in Al-Ahsa area, Kingdom of Saudi Arabia from May 2008 through April 2009 were reviewed. Inclusion criteria were healthy non-polycythemic G6PD-deficient Ahsai males born at less than or equal to 37 weeks gestation, weighing less than or equal to 2.5 kg, with no other cause of hyperbilirubinemia, and were sampled for a total serum bilirubin (TSB) within the first 48 hours of life. Hyperbilirubinemics were compared with non-hyperbilirubinemic newborns.

RESULTS: Among the 93 G6PD-deficient newborns that met the inclusion criteria, 67 were hyperbilirubinemic and required phototherapy, and 13 of them required re-phototherapy. Phototherapy was started at 11 +/- 4 (mean +/- SD) hours of life, and for a total duration of 42 +/- 28 hours. Hyperbilirubinemics had statistically significant higher levels of both hematocrit (53 +/- 6 versus 49 +/- 8%, p=0.02) and hemoglobin (176 +/- 18 versus 166 +/- 21 g/L, p=0.04), and lower reticulocyte percentage (4.3 +/- 0.7 versus 5.2 +/- 1.0 %, p=0.02), when compared to non-hyperbilirubinemic newborns.

CONCLUSION: Hyperbilirubinemia in G6PD-deficient Ahsai male newborns was characterized by higher levels of both hematocrit and hemoglobin levels, and lower reticulocyte percentage compared to their non-hyperbilirubinemic counterpart. This hyperbilirubinemia required early phototherapy and re-phototherapy. Appropriate follow up should be made available to those high-risk newborns. Further research is needed to understand the exact mechanism of hyperbilirubinemia in G6PD-deficient newborns.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 31 (2)
Saudi Medical Journal
Vol. 31, Issue 2
1 Feb 2010
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Hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient male newborns in Al-Ahsa, Saudi Arabia
Sameer Y. Al-Abdi, Taher A. Mousa, Maryam A. Al-Aamri, Najeeb G. Ul-Rahman, Ayman I. Abou-Mehrem
Saudi Medical Journal Feb 2010, 31 (2) 175-179;

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Hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient male newborns in Al-Ahsa, Saudi Arabia
Sameer Y. Al-Abdi, Taher A. Mousa, Maryam A. Al-Aamri, Najeeb G. Ul-Rahman, Ayman I. Abou-Mehrem
Saudi Medical Journal Feb 2010, 31 (2) 175-179;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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