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Review ArticleReview Article
Open Access

Clinical review of treatment options for major depressive disorder in patients with coronary heart disease

Fahad D. Alosaimi and Brian Baker
Saudi Medical Journal November 2012, 33 (11) 1159-1168;
Fahad D. Alosaimi
Department of Psychiatry, King Khalid University Hospital, King Saud University, PO Box 7805, Riyadh 11472, Kingdom of Saudi Arabia. Tel. +966 (1) 4671226. Fax. +966 (1) 4672571. E-mail: [email protected]
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Brian Baker
Department of Psychiatry, King Khalid University Hospital, King Saud University, PO Box 7805, Riyadh 11472, Kingdom of Saudi Arabia. Tel. +966 (1) 4671226. Fax. +966 (1) 4672571. E-mail: [email protected]
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Abstract

It is established that the prevalence of major depressive disorder (MDD) in coronary heart disease (CHD) populations is high and is associated with increased mortality. In this systematic review, we examined the evidence for the effective treatment of MDD in CHD patients by reviewing randomized control trials (RCTs) between 1980 and 2011 and then assessing whether these treatments were clinically meaningful. A total of 8 RCTs were retrieved. Sertraline, citalopram, and mirtazapine were safe from a cardiac perspective, but only sertraline and citalopram were clearly more effective than placebo in CHD patients with moderate-to-severe type, recurrent MDD, or MDD episode onset before the CHD event. Augmenting sertraline with omega-3 fatty acids did not result in superior depression outcomes. Cognitive-behavioral therapy was equivocally superior to usual care. Interpersonal psychotherapy was only superior to clinical management in patients with high baseline functional status. Exercise is a potential treatment for those with mild depression.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 33 (11)
Saudi Medical Journal
Vol. 33, Issue 11
1 Nov 2012
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Clinical review of treatment options for major depressive disorder in patients with coronary heart disease
Fahad D. Alosaimi, Brian Baker
Saudi Medical Journal Nov 2012, 33 (11) 1159-1168;

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Clinical review of treatment options for major depressive disorder in patients with coronary heart disease
Fahad D. Alosaimi, Brian Baker
Saudi Medical Journal Nov 2012, 33 (11) 1159-1168;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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