Skip to main content

Main menu

  • Home
  • Content
    • Latest
    • Archive
    • home
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
    • Join SMJ
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Advertising
    • Alerts
    • Feedback
    • Folders
    • Help
  • Other Publications
    • NeuroSciences Journal

User menu

  • My alerts
  • Log in

Search

  • Advanced search
Saudi Medical Journal
  • Other Publications
    • NeuroSciences Journal
  • My alerts
  • Log in
Saudi Medical Journal

Advanced Search

  • Home
  • Content
    • Latest
    • Archive
    • home
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
    • Join SMJ
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Advertising
    • Alerts
    • Feedback
    • Folders
    • Help
  • Follow psmmc on Twitter
  • Visit psmmc on Facebook
  • RSS
Review ArticleSystematic Review
Open Access

High serum uric acid levels may increase mortality and major adverse cardiovascular events in patients with acute myocardial infarction

Qiyao Xu, Mei Zhang, Iruni R. Abeysekera and Xiaolong Wang
Saudi Medical Journal June 2017, 38 (6) 577-585; DOI: https://doi.org/10.15537/smj.2017.6.17190
Qiyao Xu
From the Cardiology Center (Xu, Zhang), the Affiliated Hospital of Logistics University of PAP, Tianjin, from the Department of Physiology and Pathophysiology (Abeysekera), Tianjin Medical University, Tianjin, and from The second people’s hospital of Yichang (Xu), Hubei, China, and from Klinikum rechts der Isar Technical University of Munich (Wang), Munich, Germany
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mei Zhang
From the Cardiology Center (Xu, Zhang), the Affiliated Hospital of Logistics University of PAP, Tianjin, from the Department of Physiology and Pathophysiology (Abeysekera), Tianjin Medical University, Tianjin, and from The second people’s hospital of Yichang (Xu), Hubei, China, and from Klinikum rechts der Isar Technical University of Munich (Wang), Munich, Germany
MD, PHD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: [email protected]
Iruni R. Abeysekera
From the Cardiology Center (Xu, Zhang), the Affiliated Hospital of Logistics University of PAP, Tianjin, from the Department of Physiology and Pathophysiology (Abeysekera), Tianjin Medical University, Tianjin, and from The second people’s hospital of Yichang (Xu), Hubei, China, and from Klinikum rechts der Isar Technical University of Munich (Wang), Munich, Germany
MBBS
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Xiaolong Wang
From the Cardiology Center (Xu, Zhang), the Affiliated Hospital of Logistics University of PAP, Tianjin, from the Department of Physiology and Pathophysiology (Abeysekera), Tianjin Medical University, Tianjin, and from The second people’s hospital of Yichang (Xu), Hubei, China, and from Klinikum rechts der Isar Technical University of Munich (Wang), Munich, Germany
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • eLetters
  • Info & Metrics
  • References
  • PDF
Loading

References

  1. ↵
    1. Jernberg T,
    2. Johanson P,
    3. Held C,
    4. Svennblad B,
    5. Lindbäck J,
    6. Wallentin L
    (2011) Association between adoption of evidence-based treatment and survival for patients with ST-elevation myocardial infarction. JAMA 305:1677–1684.
    OpenUrlCrossRefPubMedWeb of Science
  2. ↵
    1. Becker BF
    (1993) Towards the physiological function of uric acid. Free Radic Biol Med 14:615–631.
    OpenUrlCrossRefPubMedWeb of Science
  3. ↵
    1. Gavin AR,
    2. Struthers AD
    (2003) Hyperuricemia and adverse outcomes in cardiovascular disease: potential for therapeutic intervention. Am J Cardiovasc Drugs 3:309–314.
    OpenUrlCrossRefPubMed
  4. ↵
    1. Karalius VP,
    2. Shoham DA
    (2013) Dietary sugar and artificial sweetener intake and chronic kidney disease: a review. Adv Chronic Kidney Dis 20:157–164.
    OpenUrlCrossRefPubMedWeb of Science
  5. ↵
    1. Kuwabara M
    (2016) Hyperuricemia, Cardiovascular Disease, and Hypertension. Pulse (Basel) 3:242–252.
    OpenUrl
  6. ↵
    1. Braga F,
    2. Pasqualetti S,
    3. Ferraro S,
    4. Panteghini M
    (2016) Hyperuricemia as risk factor for coronary heart disease incidence and mortality in the general population: a systematic review and meta-analysis. Clin Chem Lab Med 54:7–15.
    OpenUrl
  7. ↵
    1. Kim SY,
    2. Guevara JP,
    3. Kim KM,
    4. Choi HK,
    5. Heitjan DF,
    6. Albert DA
    (2010) Hyperuricemia and coronary heart disease: a systematic review and meta-analysis. Arthritis Care Res (Hoboken) 62:170–180.
    OpenUrl
  8. ↵
    1. Feig DI,
    2. Kang DH,
    3. Johnson RJ
    (2008) Uric acid and cardiovascular risk. N Engl J Med 359:1811–1821.
    OpenUrlCrossRefPubMedWeb of Science
  9. ↵
    1. Yan L,
    2. Liu Z,
    3. Zhang C
    (2014) Uric acid as a predictor of in-hospital mortality in acute myocardial infarction: a meta-analysis. Cell Biochem Biophys 70:1597–1601.
    OpenUrl
  10. ↵
    1. Trkulja V,
    2. Car S
    (2012) On-admission serum uric acid predicts outcomes after acute myocardial infarction: systematic review and meta-analysis of prognostic studies. Croat Med J 53:162–172.
    OpenUrlPubMed
  11. ↵
    1. Stroup DF,
    2. Berlin JA,
    3. Morton SC,
    4. Olkin I,
    5. Williamson GD,
    6. Rennie D,
    7. et al.
    (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 283:2008–2012.
    OpenUrlCrossRefPubMedWeb of Science
  12. ↵
    1. Stang A
    (2010) Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analysis. Eur J Epidemiol 25:603–605.
    OpenUrlCrossRefPubMedWeb of Science
  13. ↵
    1. DerSimonian R,
    2. Laird N
    (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177–188.
    OpenUrlCrossRefPubMedWeb of Science
  14. ↵
    1. Higgins JP
    (2008) Commentary: Heterogeneity in meta-analysis should be expected and appropriately quantified. Int J Epidemiol 37:1158–1160.
    OpenUrlCrossRefPubMedWeb of Science
  15. ↵
    1. Higgins JP,
    2. Thompson SG,
    3. Deeks JJ,
    4. Altman DG
    (2003) Measuring inconsistency in meta-analysis. BMJ 327:557–560.
    OpenUrlFREE Full Text
  16. ↵
    1. Sterne JA,
    2. Egger M,
    3. Smith GD
    (2001) Systematic reviews in health care: Investigating and dealing with publication and other biases in meta-analysis. BMJ 323:101–105.
    OpenUrlFREE Full Text
  17. ↵
    1. Sterne JA,
    2. Egger M
    (2001) Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. J Clin Epidemiol 54:1046–1055.
    OpenUrlCrossRefPubMedWeb of Science
  18. ↵
    1. Gazi E,
    2. Temiz A,
    3. Altun B,
    4. Barutçu A,
    5. Bekler A,
    6. Güngör O,
    7. et al.
    (2014) The association between serum uric acid level and heart failure and mortality in the early period of ST-elevation acute myocardial infarction. Turk Kardiyol Dern Ars 42:501–508.
    OpenUrl
  19. ↵
    1. Akgul O,
    2. Uyarel H,
    3. Pusuroglu H,
    4. Gul M,
    5. Isiksacan N,
    6. Turen S,
    7. et al.
    (2014) Predictive Value of Elevated Uric Acid in Turkish Patients Undergoing Primary Angioplasty for ST Elevation Myocardial Infarction. Acta Cardiol Sin 30:119–127.
    OpenUrl
  20. ↵
    1. Lazzeri C,
    2. Valente S,
    3. Chiostri M,
    4. Picariello C,
    5. Gensini GF
    (2012) Uric acid in the early risk stratification of ST-elevation myocardial infarction. Intern Emerg Med 7:33–39.
    OpenUrlPubMed
  21. ↵
    1. Omidvar B,
    2. Ayatollahi F,
    3. Alasti M
    (2012) The prognostic role of serum uric acid level in patients with acute ST elevation myocardial infarction. J Saudi Heart Assoc 24:73–78.
    OpenUrl
  22. ↵
    1. Chen L,
    2. Li XL,
    3. Qiao W,
    4. Ying Z,
    5. Qin YL,
    6. Wang Y,
    7. et al.
    (2012) Serum uric acid in patients with acute ST-elevation myocardial infarction. World J Emerg Med 3:35–39.
    OpenUrl
  23. ↵
    1. Kaya MG,
    2. Uyarel H,
    3. Akpek M,
    4. Kalay N,
    5. Ergelen M,
    6. Ayhan E,
    7. et al.
    (2012) Prognostic value of uric acid in patients with ST-elevated myocardial infarction undergoing primary coronary intervention. Am J Cardiol 109:486–491.
    OpenUrlCrossRefPubMed
  24. ↵
    1. Akpek M,
    2. Kaya MG,
    3. Uyarel H,
    4. Yarlioglues M,
    5. Kalay N,
    6. Gunebakmaz O,
    7. et al.
    (2011) The association of serum uric acid levels on coronary flow in patients with STEMI undergoing primary PCI. Atherosclerosis 219:334–341.
    OpenUrlCrossRefPubMedWeb of Science
  25. ↵
    1. Bae MH,
    2. Lee JH,
    3. Lee SH,
    4. Park SH,
    5. Yang DH,
    6. Park HS,
    7. et al.
    (2011) Serum uric acid as an independent and incremental prognostic marker in addition to N-terminal pro-B-type natriuretic peptide in patients with acute myocardial infarction. Circ J 75:1440–1447.
    OpenUrlCrossRefPubMed
  26. ↵
    1. Basar N,
    2. Sen N,
    3. Ozcan F,
    4. Erden G,
    5. Kanat S,
    6. Sokmen E,
    7. et al.
    (2011) Elevated serum uric acid predicts angiographic impaired reperfusion and 1-year mortality in ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention. J Investig Med 59:931–937.
    OpenUrlAbstract/FREE Full Text
  27. ↵
    1. Lazzeri C,
    2. Valente S,
    3. Chiostri M,
    4. Sori A,
    5. Bernardo P,
    6. Gensini GF
    (2010) Uric acid in the acute phase of ST elevation myocardial infarction submitted to primary PCI: its prognostic role and relation with inflammatory markers: a single center experience. Int J Cardiol 138:206–209.
    OpenUrlCrossRefPubMed
  28. ↵
    1. Kowalczyk J,
    2. Francuz P,
    3. Swoboda R,
    4. Lenarczyk R,
    5. Sredniawa B,
    6. Golda A,
    7. et al.
    (2010) Prognostic significance of hyperuricemia in patients with different types of renal dysfunction and acute myocardial infarction treated with percutaneous coronary intervention. Nephron Clin Pract 116:c114–c122.
    OpenUrlCrossRefPubMed
  29. ↵
    1. Car S,
    2. Trkulja V
    (2009) Higher serum uric acid on admission is associated with higher short-term mortality and poorer long-term survival after myocardial infarction: retrospective prognostic study. Croat Med J 50:559–566.
    OpenUrlCrossRefPubMed
  30. ↵
    1. Kojima S,
    2. Sakamoto T,
    3. Ishihara M,
    4. Kimura K,
    5. Miyazaki S,
    6. Yamagishi M,
    7. et al.
    (2005) Prognostic usefulness of serum uric acid after acute myocardial infarction (the Japanese Acute Coronary Syndrome Study). Am J Cardiol 96:489–495.
    OpenUrlCrossRefPubMedWeb of Science
  31. ↵
    1. Oh J,
    2. Won HY,
    3. Kang SM
    (2009) Uric acid and cardiovascular risk. N Engl J Med 360:539–540, author reply 540-541.
    OpenUrlPubMedWeb of Science
    1. Johnson RJ,
    2. Kang DH,
    3. Feig D,
    4. Kivlighn S,
    5. Kanellis J,
    6. Watanabe S,
    7. et al.
    (2003) Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? Hypertension 41:1183–1190.
    OpenUrlCrossRefPubMed
    1. George J,
    2. Carr E,
    3. Davies J,
    4. Belch JJ,
    5. Struthers A
    (2006) High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid. Circulation 114:2508–2516.
    OpenUrlAbstract/FREE Full Text
    1. Doehner W,
    2. Anker SD
    (2005) Xanthine oxidase inhibition for chronic heart failure: is allopurinol the next therapeutic advance in heart failure. Heart 91:707–709.
    OpenUrlAbstract/FREE Full Text
    1. Souza-Junior T,
    2. Lorenço-Lima L,
    3. Ganini D,
    4. Vardaris C,
    5. Polotow T,
    6. Barros M
    (2014) Delayed uric Acid accumulation in plasma provides additional anti-oxidant protection against iron-triggered oxidative stress after a wingate test. Biol Sport 31:271–276.
    OpenUrl
  32. ↵
    1. Nihei H,
    2. Kanemitsu H,
    3. Tamura A,
    4. Oka H,
    5. Sano K
    (1989) Cerebral uric acid, xanthine, and hypoxanthine after ischemia: the effect of allopurinol. Neurosurgery 25:613–617.
    OpenUrlCrossRefPubMed
  33. ↵
    1. von LTG,
    2. Girerd N,
    3. Atar D,
    4. Agewall S,
    5. Lamiral Z,
    6. Kanbay M,
    7. et al.
    (2015) Serum uric acid is associated with mortality and heart failure hospitalizations in patients with complicated myocardial infarction: findings from the High-Risk Myocardial Infarction Database Initiative. Eur J Heart Fail 17:1144–1151.
    OpenUrl
  34. ↵
    1. Levantesi G,
    2. Marfisi RM,
    3. Franzosi MG,
    4. Maggioni AP,
    5. Nicolosi GL,
    6. Schweiger C,
    7. et al.
    (2013) Uric acid: a cardiovascular risk factor in patients with recent myocardial infarction. Int J Cardiol 167:262–269.
    OpenUrl
  35. ↵
    1. Baumann S,
    2. Huseynov A,
    3. Koepp J,
    4. Jabbour C,
    5. Behnes M,
    6. Becher T,
    7. et al.
    (2016) Comparison of Serum Uric Acid, Bilirubin, and C-Reactive Protein as Prognostic Biomarkers of In-Hospital MACE Between Women and Men With ST-Segment Elevation Myocardial Infarction. Angiology 67:272–280.
    OpenUrlCrossRefPubMed
    1. Holme I,
    2. Aastveit AH,
    3. Hammar N,
    4. Jungner I,
    5. Walldius G
    (2009) Uric acid and risk of myocardial infarction, stroke and congestive heart failure in 417,734 men and women in the Apolipoprotein MOrtality RISk study (AMORIS). J Intern Med 266:558–570.
    OpenUrlCrossRefPubMedWeb of Science
  36. ↵
    1. Tatli E,
    2. Aktoz M,
    3. Buyuklu M,
    4. Altun A
    (2008) The relationship between coronary artery disease and uric acid levels in young patients with acute myocardial infarction. Cardiol J 15:21–25.
    OpenUrlPubMed
  37. ↵
    1. Elisaf M,
    2. Tsimichodimos V,
    3. Bairaktari E,
    4. Siamopoulos KC
    (1999) Effect of micronized fenofibrate and losartan combination on uric acid metabolism in hypertensive patients with hyperuricemia. J Cardiovasc Pharmacol 34:60–63.
    OpenUrlCrossRefPubMedWeb of Science
    1. Desager JP,
    2. Hulhoven R,
    3. Harvengt C
    (1980) Uricosuric effect of fenofibrate in healthy volunteers. J Clin Pharmacol 20:560–564.
    OpenUrlPubMedWeb of Science
  38. ↵
    1. Grassi D,
    2. Ferri L,
    3. Desideri G,
    4. Di Giosia P,
    5. Cheli P,
    6. Del Pinto R,
    7. et al.
    (2013) Chronic hyperuricemia, uric acid deposit and cardiovascular risk. Curr Pharm Des 19:2432–2438.
    OpenUrlPubMed
  39. ↵
    1. Onat A,
    2. Uyarel H,
    3. Hergenç G,
    4. Karabulut A,
    5. Albayrak S,
    6. Sari I,
    7. et al.
    (2006) Serum uric acid is a determinant of metabolic syndrome in a population-based study. Am J Hypertens 19:1055–1062.
    OpenUrlCrossRefPubMed
  40. ↵
    1. Høieggen A,
    2. Alderman MH,
    3. Kjeldsen SE,
    4. Julius S,
    5. Devereux RB,
    6. De Faire U,
    7. et al.
    (2004) The impact of serum uric acid on cardiovascular outcomes in the LIFE study. Kidney Int 65:1041–1049.
    OpenUrlCrossRefPubMedWeb of Science
    1. Escobar C,
    2. Barrios V,
    3. Calderón A,
    4. Barrios S,
    5. Echarri R,
    6. Navarro-Cid J,
    7. et al.
    (2008) Electrocardiographic left ventricular hypertrophy regression induced by an angiotensin receptor blocker-based regimen in hypertensive patients with the metabolic syndrome: data from the SARA Study. J Clin Hypertens (Greenwich) 10:208–214.
    OpenUrlPubMed
  41. ↵
    1. Athyros VG,
    2. Mikhailidis DP,
    3. Liberopoulos EN,
    4. Kakafika AI,
    5. Karagiannis A,
    6. Papageorgiou AA,
    7. et al.
    (2007) Effect of statin treatment on renal function and serum uric acid levels and their relation to vascular events in patients with coronary heart disease and metabolic syndrome: a subgroup analysis of the GREek Atorvastatin and Coronary heart disease Evaluation (GREACE) Study. Nephrol Dial Transplant 22:118–127.
    OpenUrlCrossRefPubMedWeb of Science
  42. ↵
    1. Feig DI,
    2. Soletsky B,
    3. Johnson RJ
    (2008) Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial. JAMA 300:924–932.
    OpenUrlCrossRefPubMedWeb of Science
  43. ↵
    1. Grundy SM,
    2. Hansen B,
    3. Smith SC,
    4. Cleeman JI,
    5. Kahn RA
    (2004) Clinical management of metabolic syndrome: report of the American Heart Association/National Heart, Lung, and Blood Institute/American Diabetes Association conference on scientific issues related to management. Circulation 109:551–556.
    OpenUrlFREE Full Text
  44. ↵
    1. Yildiz BS,
    2. Ozkan E,
    3. Esin F,
    4. Alihanoglu YI,
    5. Ozkan H,
    6. Bilgin M,
    7. et al.
    (2016) Does high serum uric acid level cause aspirin resistance? Blood Coagul Fibrinolysis 27:412–418.
    OpenUrl
  45. ↵
    1. Barbieri L,
    2. Verdoia M,
    3. Pergolini P,
    4. Nardin M,
    5. Rolla R,
    6. Marino P,
    7. et al.
    (2016) Uric acid and high-residual platelet reactivity in patients treated with clopidogrel or ticagrelor. Nutr Metab Cardiovasc Dis 26:352–358.
    OpenUrl
  46. ↵
    1. Nardin M,
    2. Verdoia M,
    3. Pergolini P,
    4. Rolla R,
    5. Barbieri L,
    6. Schaffer A,
    7. et al.
    (2016) Serum uric acid levels during dual antiplatelet therapy with ticagrelor or clopidogrel: Results from a single-centre study. Nutr Metab Cardiovasc Dis 26:567–574.
    OpenUrl
PreviousNext
Back to top

In this issue

Saudi Medical Journal: 38 (6)
Saudi Medical Journal
Vol. 38, Issue 6
1 Jun 2017
  • Table of Contents
  • Cover (PDF)
  • Index by author
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on Saudi Medical Journal.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
High serum uric acid levels may increase mortality and major adverse cardiovascular events in patients with acute myocardial infarction
(Your Name) has sent you a message from Saudi Medical Journal
(Your Name) thought you would like to see the Saudi Medical Journal web site.
Citation Tools
High serum uric acid levels may increase mortality and major adverse cardiovascular events in patients with acute myocardial infarction
Qiyao Xu, Mei Zhang, Iruni R. Abeysekera, Xiaolong Wang
Saudi Medical Journal Jun 2017, 38 (6) 577-585; DOI: 10.15537/smj.2017.6.17190

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
High serum uric acid levels may increase mortality and major adverse cardiovascular events in patients with acute myocardial infarction
Qiyao Xu, Mei Zhang, Iruni R. Abeysekera, Xiaolong Wang
Saudi Medical Journal Jun 2017, 38 (6) 577-585; DOI: 10.15537/smj.2017.6.17190
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Footnotes
    • References
  • Figures & Data
  • eLetters
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Association of hyperuricaemia and hyperglycaemia with risk of in-hospital mortality in acute aortic dissection: a multicentre cohort study in the Han Chinese population
  • Association of serum uric acid levels with cardiovascular and all-cause mortality in hypertensive patients in China: a cohort study
  • Google Scholar

More in this TOC Section

  • Breast cancer incidence after hormonal treatment for infertility
  • Pocket-creation method versus conventional method of endoscopic submucosal dissection for early gastric cancer
  • Advancing genetic counselling in Southern Africa
Show more Systematic Review

Similar Articles

CONTENT

  • home

JOURNAL

  • home

AUTHORS

  • home
Saudi Medical Journal

© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

Powered by HighWire