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Open Access

A comprehensive review of the prevalence of beta globin gene variations and the co-inheritance of related gene variants in Saudi Arabians with beta-thalassemia

Mousa A. Alaithan, Sayed AbdulAzeez and J. Francis Borgio
Saudi Medical Journal April 2018, 39 (4) 329-335; DOI: https://doi.org/10.15537/smj.2018.4.21360

Article Figures & Data

Figures

  • Figure 1
    Figure 1

    Histogram shows the percentages of population who screened with HBB mutations either as homozygous or heterozygous (carrier/affected).

  • Figure 2
    Figure 2

    Map illustrates the spectrum of various HBB gene variations. It turns out that the Eastern Province and Makkah region which were with more number of mutations through prevalence studies in Saudis. Hufuf, Qatif, and Dammam are the centers where the reported mutations came from at the studies in the Eastern Province.

  • Figure 3
    Figure 3

    Illustration for the co-inheritance of other gene mutations with HBB gene mutations. The outer grey circle imbedded with a tri-divided colored circle represented 3 HBB gene variations. Each one of the HBB mutation segment overlap exhibits the co-existence of other mutations that floated above them.

Tables

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