Prostate cancer in the Arab population

Genetic factors

It is estimated that 25% of newly diagnosed cancers in men are prostate cancers. Middle Eastern, North African, and Asian men were found to have a lower prevalence of prostate cancer, but it is the most diagnosed cancer among Swedish men.10 Molecular differences in prostate carcinomas have not been widely explored across broad geographical regions. Nonetheless, prostate cancer is more frequent among black men and usually presents advanced-stage disease in comparison to white American men.11

Ethnic differences in genotype frequencies also exist for both SRD5A2 and CYP3A4, both of which have been previously associated with increased prostate cancer risks (black men have the highest frequency of those alleles11). The CAG repeat length differs in different populations and is related to the occurrence and evolution of prostate cancer.12,13

Dietary factors

A low-fat diet has been postulated to lead to lower serum testosterone levels.2 To establish a relationship between hormonal levels in different age groups and the risk of developing prostate cancer, extensive research work is required. Whether low rates of prostate cancer diagnoses in Arab countries will change in the future due to changes in dietary habits and other environmentally related risk factors remains to be observed.2 The Mediterranean diet has been correlated with low androstenedione, testosterone, and free testosterone levels,14 which is thought to help reduce the risk of prostate cancer.15

A low incidence of prostate cancer among the first generation of offspring of Middle Eastern immigrants has been evident in places such as Sweden,16 the Netherlands,17 and California (USA).18 However, with each new generation, the incidence gradually increases.17,19 Traditionally, it was thought that high fat consumption was positively correlated to prostate cancer, but findings in Saudi Arabia indicated that despite high saturated fat consumption, prostate cancer prevalence was still low.20

Androgenic factors

Despite the fact that prostate cancer incidence of prostate rates in Arab men are low (3-8 in 100,000 men/year), the factors responsible for it are unclear, and it has been established that prostate cancer risk and fluctuation in steroid hormone metabolism are strongly correlated. A study conducted on Omani and Kuwaiti men aged 15-80 years demonstrated that serum sex hormone-binding globulin, total testosterone, dehydroepiandrosterone sulfate, adrenal C19-steroids, and androstenedione levels were significantly lower compared with those of white men, particularly during the onset of adulthood.8 High serum levels of gender hormone-binding globulin, total testosterone, and dehydroepiandrosterone sulfate were found in Arabs diagnosed with prostate cancer, in comparison with individuals free of the disease. Results acquired from Arab men were compared with results from similarly aged white American men as well as German and Chinese men. Comparison between obtained results found no significant discrepancy between German and American men for mean serum levels of dehydroepiandrosterone sulfate. Results also indicated that there was no significant hormonal difference between Chinese and Arab men. High circulating androgens were found to be correlated with incidence of newly diagnosed prostate cancer in Arabs. The low incidence of prostate cancer among Arab men may be due to lower circulating androgens and adrenal precursors in comparison to white men.8,21

Socioeconomic factors

Lack of data related to prostate cancer in the MENA regions are due to multiple reasons. The fact that prostate tumors grow slowly and can take up to 10 or more years to become lethal makes it extremely difficult to study. Studying prostate cancer is expensive and time-consuming due to its prolonged onset. The reluctance of patients to participate in clinical trials may be a major contributor behind lack of data, especially in Arab populations.

The following are the main theories for the lower prevalence of prostate cancer in Arab countries: increasing average life expectancy; eradication of other endemic diseases; improving general health; globalization and environmental exposure; poor patient awareness about cancer screening; poor understanding of PSA use among doctors in Saudi Arabia; poor biopsy technique; poor pathology interpretation; lack of autopsy.

In 2008, a screening study was conducted in Riyadh, Saudi Arabia, which revealed that the prostate cancer incidence rate was high and that the disease was advanced. Riyadh ranked second in prostate cancer incidence in the country, with an estimated 2.5% incidence rate, of which 39.3% had positive biopsy results. From the cancer cases confirmed as prostate cancer, >17% had high Gleason scores, from which an estimated 27% were found to be metastatic and 21% presented as locally advanced cases. The stated figures indicate underreporting of prostate cancer in Saudi Arabia, hence leading to a delay in diagnosis and lack of awareness among individuals and health-care providers in terms of screening. This leads to the conclusion that large community-based studies are required to further understand prostate cancer.15

Screening for prostate cancer in the Arab World

For many years, there has been no scientific consensus regarding effective strategies to reduce the risk of prostate cancer. There are ongoing debates regarding the effectiveness of screening or the extent of potential benefits outweighing the risks.2 However, recent publications have demonstrated evidence that early detection results in reduced mortality in western populations.22 A recent review stated that men aged between 50 and 70 years should be encouraged to undergo PSA level screening.23

Screening decisions for prostate cancer are complex and require a physician with extensive experience and knowledge. It is imperative for physicians to seek continuous training and medical education so that they can perform screening procedures and ensure early detection of prostate cancer. Lack of knowledge and poor attitude regarding screening and treatment are challenges in the MENA region;24 therefore, these may be the main reasons behind the low detection of the disease.

Detection using serum PSA for Arab men

To date, serum PSA remains useful for detecting prostate cancer. Western countries have established a cutoff level of total PSA (4 ng/mL) to differentiate between benign and malignant prostatic diseases and to indicate when biopsies are needed. Generalization of cutoff values for all ages have been proven to be insufficient; hence, age-specific values should be considered for diagnosis.2 Both age and PSA were found to be positively correlated: PSA increases with increasing age increases.2 Studies have begun to determine population-specific ranges for PSA because racial variations may play a role.7

Detection programs using total PSA were found to have a high false-positive rate. False-positive results due to increased levels of total PSA occur in benign conditions (for example, benign prostatic hyperplasia [BPH]) as well as clinical and subclinical prostatitis.25 Increased total serum PSA from those conditions can potentially lead to diagnostic dilemmas for prostate cancer detection programs using serum PSA as the primary screening tool. American and European men were found have a low probability of clinically detectable prostate cancer if their total PSA is <2.5 ng/mL, as opposed to individuals with total PSA >10 ng/mL, who have a >50% chance of detecting prostate cancer.27 Despite the fact that PSA testing is the most common tool for diagnosing prostate cancer, it lacks specificity within a range of 4-10 ng/mL, leading to a diagnostic zone of only 25%.25

Discriminating prostate cancer from various benign diseases can be achieved by measuring different forms of PSA. Patients diagnosed with prostate cancer for unknown reasons were found to have lower levels of free PSA compared with those who have normal prostate or benign disease.27 Recent evidence indicates that using the free-to-total PSA ratio was found to be reliable in evaluating prostate cancer while having minimum loss of sensitivity in detection, especially in individuals having a total PSA range between 4 and 10 ng/mL. Individuals at highest risk for prostate cancer were found to have a free-to-total PSA ratio <25%; hence, complete investigations are required to confirm the disease.25

Urologists have noticed that despite low incidences of prostate cancer in the MENA regions, the disease has been on the rise. Arab men with serum total PSA >10 ng/mL were studied to conclude that the high false positive rate is due to BPH in comparison with European and American men with similar PSA levels who had a higher risk of developing the disease.25

Total PSA >10 ng/mL in Arab men may be the result of benign conditions such as BPH with prostatitis or prostate cancer. The presentation of BPH with prostatitis is accompanied by total PSA >10 ng/mL, with a gradual reduction <4 ng/mL with time. Free PSA and PSA density were not found to be effective diagnostic tools for prostate cancer. In comparison with white American and European men, PSA levels >10 ng/mL in Arabs were found to be due to BPH with prostatitis.25,26

Age-specific reference ranges of PSA in Arabs

Arabs exhibit lower prostate volumes and PSA levels in comparison to white men.7,27 Lower PSA levels in Asian men (Arabs included) are thought be due to lower prostate volumes and difference in the cellular composition of the prostate glands.7 Prostate volume and levels of serum PSA are age- and race-dependent, indicating the importance of having age-specific reference ranges for these variables, thus leading to an increase in the positive predictive value of PSA, which will result in proper estimation of prostate cancer diagnosis in individual communities.

In 2003, age- and population-specific reference ranges for PSA of Saudi men have been defined.27 Men between 40 and 89 years were found to have normal values. The mean normal PSA values based on age were the following: 40-49 years, 0.87 ng/mL; 50-59 years, 1.36 ng/mL; 60-69 years, 1.81 ng/mL; 70-79 years, 2.32 ng/mL; 80-89 years, 2.36 ng/mL, for which all age groups had >30% free PSA. Men having PSA levels <4 ng/mL were found to have unchanged free PSA percentages, of which only 16.6% had a free–to-total PSA ratio of 18%, making the upper limit of PSA in Saudi men similar to that of Korean and Chinese men. The study found that Saudi men have lower PSA values than white men. The free PSA percentage for men with PSA <4 ng/mL may therefore be used as a race-specific value for diagnosing prostate cancer.27

A 2005 study of healthy Kuwaiti and Omani men arrived at the same conclusion that Arab men have lower PSA levels and smaller prostate volumes in comparison to white men, similar to those of Chinese and Japanese men.7 Age-specific reference ranges for PSA have been determined along with the prostate volumes of men between 15 and 79 years from the previous study. The prostate volume of men >40 years were determined by conducting transrectal ultrasonography and digital rectal examination. The PSA serum ranges for each age group of Arab men were the following: 40-49 years, 0-0.9 ng/mL (prostate volume, 8-22 mL); 60-69 years, 0-2.7 ng/mL (prostate volume, 9–30 mL); 70-79 years, 0-5.5 ng/mL (prostate volume, 10-33 mL),7 thus concluding that serum PSA and prostate volume are directly proportional with age.7

Serum PSA in Arab and Asian men diagnosed with BPH with prostatitis were higher in comparison with white men. The reason for this is unknown, but one theory points to the presence of late prostatic symptoms.25,26 Kehinde et al25 reported that 17.7% of elevated PSA levels in patients were due to prostate cancer, whereas 58.6% were due to BPH and 23.7% were due to BPH with prostatitis. Similar results were found in Kuwait. Serum total PSA >10 ng/mL can lead physicians practicing in Arab and Asian countries to miss the diagnosis.25

To date, no other tumor markers have been detected to enhance the specificity or sensitivity of total or free PSA. Transurethral prostatic resection may lead to a decrease in PSA levels to normal values with or without prostatitis treatment in BPH patients. This study indicates that Arabs with total PSA >10 ng/mL do not have prostate cancer. An increase in the PSA level may indicate prostate cancer, requiring repetition of clinical and histological evaluation.25

A study of the Saudi population in 2010 compared the diagnostic utility of complexed PSA, total PSA, and their ratios with free PSA for BPH and prostate cancer. The data from this study showed few advantages with the use of complexed PSA instead of total PSA for discriminating BPH and prostate cancer.30

Age-specific PSA cutoff level for Arab men

A study supporting early diagnosis of prostate cancer investigated age-specific PSA cutoff values in Arab men. According to the findings, using lower cutoff values for PSA may frequently detect prostate cancer while it is still curable. Three reasons have been established as to why screening PSA with a lower threshold is useful in men aged 40-49 years. First, younger men have a lower incidence of BPH. Second, screening in younger men is more likely to detect localized, curable cancer. Third, younger men are less likely to have significant medical comorbidities and are more likely to undergo radical treatments such as surgery.

Prostate cancer is prevalent in 25% of men with PSA level between 4 and 10 ng/mL and also in 25% of men with PSA level <4 ng/mL. This poor specificity has led to the establishment of age-adjusted PSA level thresholds. As the difference in incidence of BPH between men younger than 60 years and older than 60 years increases (<60 years, 9%; >60 years, 17%), the screening of younger men should yield fewer false-positive results.29

A 2008 study of Egyptian men explored prostate cancer detection in patients younger than 50 years using a PSA cutoff of <4 ng/mL. Twenty-eight samples were drawn from 2 groups of men, group A (<50 years; mean age, 46 years) and group B (>50 years; mean age, 58 years). Differences in pathological findings, PSA levels, digital rectal examination findings, and body mass index between groups were measured. The mean PSA level was 1.9±1.6 ng/mL in group A and 2±1.6 ng/mL in group B, and 1.8% of the patients in group A and 10.7% of the patients in B tested positive for prostatic adenocarcinoma. Group A was found to have a higher incidence of high-grade prostatic intraepithelial neoplasia (PIN) in comparison to group B (11 versus 4 cases). Digital rectal examination had no significant association with pathological findings in either group. Body mass index was found to be correlated positively with PSA levels in group A patients, but not with those in group B. A new PSA cutoff point for younger adults is acceptable. A serum PSA level of 2 ng/mL should be endorsed as a cutoff point for screening and biopsy in asymptomatic men younger than 50 years. Young patients with low serum PSA were found to have high PIN, and this should be further studied.29

This study recommends a serum PSA level of 2 ng/mL as an accurate cutoff point for screening men younger than 50 years (to avoid missing 14.3% of positive cases with PSA 2.5 ng/mL). High-grade PIN was detected histopathologically in 19.6% of this age group, prompting the need for follow-up care for prostate cancer evaluation.29

In conclusion, prostate cancer screening remains controversial in the Arab world. However, it is clear that the incidence of this disease is increasing. As the average life expectancy increases in the Arab population, prostate cancer may start to pose a health-care problem similar to that in western countries. Hence, genetic and environmental variations from region to region should be considered when establishing clinical standards.