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NewsThe Cochrane Library
Open Access

Study Reveals Early Warning Signs of Heart Problems in Patients with Newly Diagnosed Lupuss

Saudi Medical Journal September 2018, 39 (9) 956;
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AUGUST 2, 2018 - Cardiovascular disease is a leading cause of death in patients with lupus, a systemic autoimmune disease. In a new study in Arthritis & Rheumatology—a journal published by Wiley on behalf of the American College of Rheumatology—imaging tests revealed signs of cardiac impairment in patients newly diagnosed with lupus, even before any symptoms of chest discomfort.

To determine whether cardiac magnetic resonance (CMR) imaging might uncover early indicators of silent heart problems in patients with lupus, a team led by Meng Jiang, MD, PhD, FSCMR and Jun Pu, MD, PhD, FACC, of Shanghai Jiao Tong University in China, studied 50 patients recently diagnosed with lupus, 60 patients with longstanding lupus, and 50 healthy controls.

Imaging tests revealed structural and functional changes in the hearts of patients with lupus, and the extent of the changes—including signs of scarring, or fibrosis—were related to lupus stage. The findings indicate that early detection and treatment of heart problems may benefit patients with lupus.

Current tests that assess lupus patients’ heart health often do not examine changes that are visible with CMR. Therefore, CMR may be useful for detecting the markers of cardiac problems that arise early in the disease process. When these markers are evident, certain therapies may help protect patients’ hearts from additional damage.

“Our findings may affect current lupus diagnostics and treatment—meaning more patients with silent cardiac insults could be identified and receive proper treatment,” said Dr. Pu.

Also, once fibrosis appears at later stages, anti-fibrotic treatments may be appropriate, noted Dr. Jiang. “Whether these treatments will improve a patient’s prognosis still needs to be evaluated by further clinical studies,” she said.

Full citation: “Early Detection of Silent Myocardial Impairment in Patients with New Onset Drug- Naïve Systemic Lupus Erythematosus – A Three-Center Prospective Study (Myocardial Impairment in New Onset SLE).” Qiang Guo, Lian-Ming Wu, Zi Wang, Jia-Yan Shen, Xuan Su, Chang-Qian Wang, Xing-Rong Gong, Qing-Ran Yan, Qing He, Wei Zhang, Jian-Rong Xu, Meng Jiang, and Jun Pu. Arthritis & Rheumatology; Published Online: August 2, 2018 (DOI: 10.1002/art.40671).

Copyright © 2018 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd., reproduced with permission.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 39 (9)
Saudi Medical Journal
Vol. 39, Issue 9
1 Sep 2018
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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