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Clinical significance of Saussurea Costus in thyroid treatment

Muhammad Mujammami
Saudi Medical Journal October 2020, 41 (10) 1047-1053; DOI: https://doi.org/10.15537/smj.2020.10.25416

References

  1. ↵
    1. Shah R
    (2004) Nature's Medicinal Plants of Uttaranchal:(Herbs, Grasses and Ferns) (Scientific Research, Gyanodaya Prakashan (IN)).
  2. ↵
    1. Ansari S
    (2019) Ethnobotany and Pharmacognosy of Qust/Kut (Saussurea lappa, CB Clarke) with Special Reference of Unani Medicine. Pharmacogn Rev 13:71–76.
    OpenUrl
  3. ↵
    1. Negi VS,
    2. Kewlani P,
    3. Pathak R,
    4. Bhatt D,
    5. Bhatt ID,
    6. Rawal RS,
    7. et al.
    (2018) Criteria and indicators for promoting cultivation and conservation of Medicinal and Aromatic Plants in Western Himalaya, India. Ecol Indic 93:434–446.
    OpenUrl
  4. ↵
    1. Alnahdi HS
    (2017) Injury in metabolic gland induced by pyrethroid insecticide could be reduced by aqueous extract of Sassura lappa. International Journal of Pharmaceutical Research &Allied Sciences 6:97–86.
    OpenUrl
  5. ↵
    1. Al-Adhroey AH,
    2. Al-Abhar YM,
    3. Noman NM,
    4. Al-Mekhlafi HM
    (2020) Ethnopharmacological survey of herbal remedies used for treating malaria in Yemen. J Herb Med 21:100332.
    OpenUrl
  6. ↵
    1. Chen SL,
    2. Yu H,
    3. Luo HM,
    4. Wu Q,
    5. Li CF,
    6. Steinmetz A
    (2016) Conservation and sustainable use of medicinal plants:problems, progress, and prospects. Chin Med 11:37.
    OpenUrl
  7. ↵
    1. Ebadi N,
    2. Bagheri S,
    3. Manayi A,
    4. Toliyat T,
    5. Sadrai S,
    6. Tabarrai M,
    7. et al.
    (2018) Determination of scientific name of bitter “Qust”:an important controversial plant source in the Iranian medicinal plants market for neurological complications. Research Journal of Pharmacognosy 5:25–32.
    OpenUrl
  8. ↵
    1. Hassan R,
    2. Masoodi MH
    (2020) Saussurea lappa:A comprehensive review on its pharmacological activity and phytochemistry. Curr Tradit Med 6:13–23.
    OpenUrl
  9. ↵
    1. de Andrade EF,
    2. Carpiné D,
    3. Dagostin JL,
    4. Barison A,
    5. Rüdiger AL,
    6. de Muñiz GI,
    7. et al.
    (2017) Identification and antimicrobial activity of the sesquiterpene lactone mixture extracted from Smallanthus sonchifolius dried leaves. Eur Food Res Technol 243:2155–2161.
    OpenUrl
  10. ↵
    1. Amara U,
    2. Khan A,
    3. Laraib S,
    4. Wali R,
    5. Sarwar U,
    6. Ain QT,
    7. et al.
    (2017) Conservation status and therapeutic potential of Saussurea lappa:an overview. Am J Plant Sci 8:602–614.
    OpenUrl
  11. ↵
    1. Kadhem M
    (2019) Protective of ethanolic extract of Saussurea lappa against paracetamol-induced hepatic and renal damage in male rabbits. Asian J Pharm Clin Res 12:68–73.
    OpenUrl
  12. ↵
    1. Sheikh BY,
    2. Sarker MM,
    3. Kamarudin MN,
    4. Ismail A
    (2017) Prophetic medicine as potential functional food elements in the intervention of cancer:A review. Biomed Pharmacother 95:614–648.
    OpenUrl
  13. ↵
    1. El-Rahman GI,
    2. Behairy A,
    3. Elseddawy NM,
    4. Batiha GE,
    5. Hozzein WN,
    6. Khodeer DM,
    7. et al.
    (2020) Saussurea lappa ethanolic extract attenuates triamcinolone acetonide-induced pulmonary and splenic tissue damage in rats via modulation of oxidative stress, inflammation, and apoptosis. Antioxidants 9:396.
    OpenUrl
  14. ↵
    1. Zahara K,
    2. Tabassum S,
    3. Sabir S,
    4. Arshad M,
    5. Qureshi R,
    6. Amjad MS,
    7. et al.
    (2014) A review of therapeutic potential of Saussurea lappa-An endangered plant from Himalaya. Asian Pacific Journal of Tropical Medicine 7:S60–S69.
    OpenUrl
  15. ↵
    1. Abdallah EM,
    2. Qureshi KA,
    3. Ali AMH,
    4. Elhassan GO
    (2017) Evaluation of some biological properties of Saussurea costus crude root extract. Biosci Biotech Res Comm 10:601–611.
    OpenUrl
  16. ↵
    1. Singireesu SS,
    2. Misra S,
    3. Mondal SK,
    4. Yerramsetty S,
    5. Sahu N,
    6. K SB
    (2018) Costunolide induces micronuclei formation, chromosomal aberrations, cytostasis, and mitochondrial-mediated apoptosis in Chinese hamster ovary cells. Cell Biol Toxicol 34:125–142.
    OpenUrl
  17. ↵
    1. Tag HM,
    2. Khaled HE,
    3. Ismail HA,
    4. El-Shenawy NS
    (2016) Evaluation of anti-inflammatory potential of the ethanolic extract of the Saussurea lappa root (costus) on adjuvant-induced monoarthritis in rats. J Basic Clin Physiol Pharmacol 27:71–78.
    OpenUrl
  18. ↵
    1. Chen Z,
    2. Zhang D,
    3. Li M,
    4. Wang B
    (2018) Costunolide ameliorates lipoteichoic acid-induced acute lung injury via attenuating MAPK signaling pathway. Int Immunopharmacol 61:283–289.
    OpenUrl
  19. ↵
    1. Chauhan RS,
    2. Bahuguna YM,
    3. Nautiyal MC,
    4. Cota-Sánchez JH
    (2018) First account of vivipary in Saussurea lappa(Decne.) Sch. Bip. (Asteraceae). Braz J Bot 41:507–514.
    OpenUrl
  20. ↵
    1. Abdel-Rahman M,
    2. Rezk MM,
    3. Ahmed-Farid OA,
    4. Essam S,
    5. Abdel Moneim AE
    (2020) Saussurea lappa root extract ameliorates the hazards effect of thorium induced oxidative stress and neuroendocrine alterations in adult male rats. Environ Sci Pollut Res Int 27:13237–13246.
    OpenUrl
  21. ↵
    1. Taylor PN,
    2. Albrecht D,
    3. Scholz A,
    4. Gutierrez-Buey G,
    5. Lazarus JH,
    6. Dayan CM,
    7. et al.
    (2018) Global epidemiology of hyperthyroidism and hypothyroidism. Nat Rev Endocrinol 14:301–316.
    OpenUrlCrossRefPubMed
  22. ↵
    1. Biondi B,
    2. Kahaly GJ,
    3. Robertson RP
    (2019) Thyroid dysfunction and diabetes mellitus:two closely associated disorders. Endocr Rev 40:789–824.
    OpenUrl
  23. ↵
    1. Chaker L,
    2. Bianco AC,
    3. Jonklaas J,
    4. Peeters RP
    (2017) Hypothyroidism. The Lancet 390:1550–1562.
    OpenUrl
  24. ↵
    1. Ross DS,
    2. Burch HB,
    3. Cooper DS,
    4. Greenlee MC,
    5. Laurberg P,
    6. Maia AL,
    7. et al.
    (2016) 2016 American Thyroid Association guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis. Thyroid 26:1343–1421.
    OpenUrlCrossRefPubMed
  25. ↵
    1. Diab N,
    2. Daya NR,
    3. Juraschek SP,
    4. Martin SS,
    5. McEvoy JW,
    6. Schultheiß UT,
    7. et al.
    (2019) Prevalence and Risk factors of thyroid Dysfunction in older Adults in the community. Sci Rep 9:13156.
    OpenUrl
  26. ↵
    1. Al Shahrani AS,
    2. El-Metwally A,
    3. Al-Surimi K,
    4. Salih SB,
    5. Saleh Y,
    6. Al-Shehri A,
    7. et al.
    (2016) The epidemiology of thyroid diseases in the Arab world:A systematic review. Journal of Public Health and Epidemiology Full Length Research Paper 8:17–26.
    OpenUrl
  27. ↵
    1. Ali AAG,
    2. Altahir SA
    (2016) Prevalence of thyroids dysfunction among Saudi adult males and females from (June-September 2016). Journal of Endocrinology and Diabetes 3:1–3.
    OpenUrl
  28. ↵
    1. Aljabri KSJ,
    2. Alnasser MI,
    3. Facharatz Bokhari SA,
    4. Alshareef MA,
    5. Khan PM,
    6. et al.
    (2019) The frequency of hypothyroidism in Saudi community-based hospital:A retrospective single centre study. Trends in Diabetes and Metabolism 1:doi 10.15761/tdm.1000107.
  29. ↵
    1. Cappola AR,
    2. Desai AS,
    3. Medici M,
    4. Cooper LS,
    5. Egan D,
    6. Sopko G,
    7. et al.
    (2019) Thyroid and cardiovascular disease:research agenda for enhancing knowledge, prevention, and treatment. Circulation 139:2892–2909.
    OpenUrl
  30. ↵
    1. Journy NM,
    2. Bernier MO,
    3. Doody MM,
    4. Alexander BH,
    5. Linet MS,
    6. Kitahara CM
    (2017) Hyperthyroidism, hypothyroidism, and cause-specific mortality in a large cohort of women. Thyroid 27:1001–1010.
    OpenUrl
  31. ↵
    1. Barrea L,
    2. Gallo M,
    3. Ruggeri RM,
    4. Giacinto PD,
    5. Sesti F,
    6. Prinzi N,
    7. et al.
    Nutritional status and follicular-derived thyroid cancer:an update. Crit Rev Food Sci Nutr 2020:1–35.
  32. ↵
    1. Cho A,
    2. Chang Y,
    3. Ahn J,
    4. Shin H,
    5. Ryu S
    (2018) Cigarette smoking and thyroid cancer risk:a cohort study. Br J Cancer 119:638–645.
    OpenUrl
  33. ↵
    1. Riza E,
    2. Linos A,
    3. Petralias A,
    4. de Martinis L,
    5. Duntas L,
    6. Linos D
    (2015) The effect of Greek herbal tea consumption on thyroid cancer:a case-control study. European Journal of Public Health 25:1001–1005.
    OpenUrlCrossRefPubMed
  34. ↵
    1. Sharma AK,
    2. Basu I,
    3. Singh S
    (2018) Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients:A double-blind, randomized placebo-controlled trial. The Journal of Alternative and Complementary Medicine 24:243–248.
    OpenUrl
  35. ↵
    1. Trajčíková E,
    2. Kurin E,
    3. Slobodníková L,
    4. Straka M,
    5. Lichváriková A,
    6. Dokupilová S,
    7. et al.
    (2020) Antimicrobial and antioxidant properties of four Lycopus Taxa and an interaction study of their major compounds. Molecules 25:1422.
    OpenUrl
  36. ↵
    1. Trifan A,
    2. Opitz SE,
    3. Josuran R,
    4. Grubelnik A,
    5. Esslinger N,
    6. Peter S,
    7. et al.
    (2018) Is comfrey root more than toxic pyrrolizidine alkaloids?Salvianolic acids among antioxidant polyphenols in comfrey (Symphytum officinale L) roots. Food Chem Toxicol 112:178–187.
    OpenUrl
  37. ↵
    1. Al-Snai AE
    (2019) Chemical constituents and pharmacological effects of Lithospermum officinale. IOSR J Pharm 9:12–21.
    OpenUrl
  38. ↵
    1. Onumah BM
    (2016) Alternative and complementary treatment of thyroid disorders in thyroid cancer:A comprehensive guide to clinical management. Journal of Nuclear Medicine 58:759.
    OpenUrl
  39. ↵
    1. Chuang TY,
    2. Lien CY,
    3. Hsu CH,
    4. Lu CW,
    5. Wu CH
    (2020) Chinese herbal medicine alleviates thyroidectomy-induced cardiopulmonary exercise dysfunction in rats. Evid Based Complement Alternat Med 2020:9415082.
    OpenUrl
  40. ↵
    1. Yang H,
    2. Cong Y,
    3. Wu T,
    4. Tang H,
    5. Ma M,
    6. Zeng J,
    7. et al.
    (2017) Clinical efficacy of Yingliu mixture combined with metimazole for treating diffuse goitre with hyperthyroidism and its impact on related cytokines. Pharmaceutical Biology 55:258–263.
    OpenUrl
  41. ↵
    1. Shen HY,
    2. Li LZ,
    3. Xue KC,
    4. Hu DD,
    5. Gao YJ
    (2017) Antitumor activity of fucoidan in anaplastic thyroid cancer via apoptosis and anti-angiogenesis. Molecular Medicine Reports 15:2620–2624.
    OpenUrl
  42. ↵
    1. Zhang Y,
    2. Li Y,
    3. Mao X,
    4. Yan C,
    5. Guo X,
    6. Guo Q,
    7. et al.
    (2016) Thyroid hormone synthesis:A potential target of a Chinese herbal formula Haizao Yuhu Decoction acting on iodine-deficient goiter. Oncotarget 7:51699–51712.
    OpenUrl
  43. ↵
    1. Tousson E,
    2. El-Atrsh A,
    3. Mansour M,
    4. Abdallah A
    (2019) Modulatory effects of Saussurea lappa root aqueous extract against ethephon-induced kidney toxicity in male rats. Environmental Toxicology 34:1277–1284.
    OpenUrl
  44. ↵
    1. Abd Eldaim MA,
    2. Tousson E,
    3. El Sayed IET,
    4. Awd WM
    (2019) Ameliorative effects of Saussurea lappa root aqueous extract against Ethephon-induced reproductive toxicity in male rats. Environmental Toxicology 34:150–159.
    OpenUrl
  45. ↵
    1. Pyun H,
    2. Kang U,
    3. Seo EK,
    4. Lee K
    (2018) Dehydrocostus lactone, a sesquiterpene from Saussurea lappa Clarke, suppresses allergic airway inflammation by binding to dimerized translationally controlled tumor protein. Phytomedicine 43:46–54.
    OpenUrl
  46. ↵
    1. Choodej S,
    2. Pudhom K,
    3. Mitsunaga T
    (2018) Inhibition of TNF-? -induced inflammation by Sesquiterpene Lactones from Saussurea lappa and semi-synthetic analogues. Planta Medica 84:329–335.
    OpenUrl
  47. ↵
    1. Lin X,
    2. Peng Z,
    3. Fu X,
    4. Liu C,
    5. Xu Y,
    6. Ji W,
    7. et al.
    (2016) Volatile oil from Saussurea lappa exerts antitumor efficacy by inhibiting epithelial growth factor receptor tyrosine kinase-mediated signaling pathway in hepatocellular carcinoma. Oncotarget 7:79761–79773.
    OpenUrl
  48. ↵
    1. Tejaswi JK,
    2. Rajan RG,
    3. Sara P
    (2018) Biological evaluation of Saussurea lappa root extract for analgesic and anti-inflammatory activity. Asian Journal of Pharmaceutical Research and Development 6:35–38.
    OpenUrl
  49. ↵
    1. Panthi S,
    2. Gao T
    (2015) Diagnosis and management of primary hypothyroidism in traditional Chinese medicine (TCM) and traditional Indian medicine (Ayurveda). Int J Clin Endocrinol Metab 1:009–012.
    OpenUrl
  50. ↵
    1. Cicatiello AG,
    2. Di Girolamo D,
    3. Dentice M
    (2018) Metabolic effects of the intracellular regulation of thyroid hormone:old players, new concepts. Front Endocrinol (Lausanne) 9:474.
    OpenUrl
  51. ↵
    1. Iglesias P,
    2. Bajo MA,
    3. Selgas R,
    4. Díez JJ
    (2017) Thyroid dysfunction and kidney disease:an update. Reviews in Endocrine and Metabolic Disorders 18:131–144.
    OpenUrl
  52. ↵
    1. Bolkiny Y,
    2. Tousson E,
    3. El-Atrsh A,
    4. Akela M,
    5. Farg E
    (2019) Costus root extract alleviates blood biochemical derangements of experimentally-induced hypo- and hyperthyroidism in mice. Annual Research &Review in Biology 31:1–10.
    OpenUrl
  53. ↵
    1. Shrestha S,
    2. Bharti A,
    3. Rai R,
    4. Singh M
    (2015) Assessment of Serum Minerals and Electrolytes in Thyroid Patients. International Journal of Advances in Scientific Research 1:259.
    OpenUrl
  54. ↵
    1. Ahmed SB,
    2. Moghazy AM,
    3. Ahmed-Farid OA,
    4. Esebery HA
    (2018) Effects of aqueous extract of polyherbal formulation against hyperthyroidism induced by L-thyroxin in a rat model. Biomedical Research and Therapy 5:2876–2887.
    OpenUrl
  55. ↵
    1. Han J,
    2. Xian Z,
    3. Zhang Y,
    4. Liu J,
    5. Liang A
    (2019) Systematic overview of Aristolochic acids:Nephrotoxicity, carcinogenicity, and underlying mechanisms. Front Pharmacol 10:648.
    OpenUrl
  56. ↵
    1. Seca AML,
    2. Silva AMS,
    3. Pinto DCGA
    (2017) Chapter 9 - Parthenolide and Parthenolide-like sesquiterpene lactones as multiple targets drugs:Current knowledge and new developments. Studies in Natural Products Chemistry 52:337–372.
    OpenUrl
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