Review ArticleReview Article
Open Access

The management of prehypertension in young adults

Ma Jun and Xiang Yali
Saudi Medical Journal March 2020, 41 (3) 223-231; DOI: https://doi.org/10.15537/smj.2020.3.24998

References

  1. ↵
    1. Meng XJ,
    2. Dong GH,
    3. Wang D,
    4. Liu MM,
    5. Liu YQ,
    6. Zhao Y,
    7. et al.
    (2012) Epidemiology of prehypertension and associated risk factors in urban adults from 33 communities in China. the CHPSNE study. Circ J 76:900–906.
    OpenUrlCrossRefPubMedWeb of Science
    1. Paquissi FC,
    2. Manuel V,
    3. Manuel A,
    4. Mateus GL,
    5. David B,
    6. Beu G,
    7. et al.
    (2016) Prevalence of cardiovascular risk factors among workers at a private tertiary center in Angola. Vasc Health Risk Manag 12:497–503.
    OpenUrl
  3. ↵
    1. Afrifa-Anane E,
    2. Agyemang C,
    3. Codjoe SN,
    4. Ogedegbe G,
    5. De-Graft AA
    (2015) The association of physical activity, body mass index and the blood pressure levels among urban poor youth in Accra, Ghana. Bmc Public Health 15:269.
    OpenUrl
  4. ↵
    1. Peng H,
    2. Ding J,
    3. Peng Y,
    4. Zhang Q,
    5. Xu Y,
    6. Chao X,
    7. et al.
    (2012) Hyperuricemia and microalbuminuria are separately and independently associated with prehypertension among Chinese Han women. Metab Syndr Relat Disord 10:202–208.
    OpenUrlCrossRefPubMed
  5. ↵
    1. Isezuo SA,
    2. Sabir AA,
    3. Ohwovorilole AE,
    4. Fasanmade OA
    (2011) Prevalence, associated factors and relationship between prehypertension and hypertension:a study of two ethnic African populations in Northern Nigeria. J Hum Hypertens 25:224–230.
    OpenUrlPubMed
  6. ↵
    1. Donahue RP,
    2. Stranges S,
    3. Rafalson L,
    4. Dmochowski J,
    5. Dorn J,
    6. Trevisan M
    (2014) Risk factors for prehypertension in the community:a prospective analysis from the Western New York Health Study. Nutr Metab Cardiovasc Dis 24:162–167.
    OpenUrlCrossRefPubMed
  7. ↵
    1. Moreira LB,
    2. Fuchs SC,
    3. Wiehe M,
    4. Gus M,
    5. Moraes RS,
    6. Fuchs FD
    (2008) Incidence of hypertension in Porto Alegre, Brazil:a population-based study. J Hum Hypertens 22:48–50.
    OpenUrlCrossRefPubMed
  8. ↵
    1. Kurioka S,
    2. Horie S,
    3. Inoue A,
    4. Mafune K,
    5. Tsuda Y,
    6. Otsuji Y
    (2014) Risk of progression to hypertension in nonhypertensive Japanese workers aged 20-64 years. J Hypertens 32:236–244.
    OpenUrlPubMed
  9. ↵
    1. Selassie A,
    2. Wagner CS,
    3. Laken ML,
    4. Ferguson ML,
    5. Ferdinand KC,
    6. Egan BM
    (2011) Progression is accelerated from prehypertension to hypertension in blacks. Hypertension 58:579–587.
    OpenUrlCrossRef
  10. ↵
    1. Huang Y,
    2. Cai X,
    3. Liu C,
    4. Zhu D,
    5. Hua J,
    6. Hu Y,
    7. et al.
    (2015) Prehypertension and the risk of coronary heart disease in Asian and Western populations:a meta-analysis. J Am Heart Assoc 4:2.
    OpenUrl
  11. ↵
    1. Wang D,
    2. Zhou Y,
    3. Guo Y,
    4. Wang C,
    5. Wang A,
    6. Jin Z,
    7. et al.
    (2015) Arterial pre-hypertension and hypertension in intracranial versus extracranial cerebrovascular stenosis. Eur J Neurol 22:533–539.
    OpenUrlCrossRefPubMed
  12. ↵
    1. Leiba A,
    2. Twig G,
    3. Vivante A,
    4. Skorecki K,
    5. Golan E,
    6. Derazne E,
    7. et al.
    (2017) Prehypertension among 2.19 million adolescents and future risk for end-stage renal disease. J Hypertens 35:1290–1296.
    OpenUrl
  13. ↵
    1. Karoli R,
    2. Bhat S,
    3. Fatima J,
    4. Shukla V,
    5. Khanduri S,
    6. Rehman M,
    7. et al.
    (2016) Simple Renal Cysts:Can They be Overlooked? J Assoc Physicians India 64:14–17.
    OpenUrl
  14. ↵
    1. Karaduman M,
    2. Aparci M,
    3. Unlu M,
    4. Ozturk C,
    5. Balta S,
    6. Celik T
    (2017) Role of screening tests in the detection and management of blood pressure abnormalities among young population. Angiology 68:441–446.
    OpenUrl
  15. ↵
    1. Kanegae H,
    2. Oikawa T,
    3. Okawara Y,
    4. Hoshide S,
    5. Kario K
    (2017) Which blood pressure measurement, systolic or diastolic, better predicts future hypertension in normotensive young adults? J Clin Hypertens (Greenwich) 19:603–610.
    OpenUrl
  16. ↵
    1. Huang Y,
    2. Qiu W,
    3. Liu C,
    4. Zhu D,
    5. Hua J,
    6. Cai X,
    7. et al.
    (2014) Prevalence and risk factors associated with prehypertension in Shunde District, southern China. BMJ Open 4:e6551.
    OpenUrl
  17. ↵
    1. Lin Y,
    2. Lai X,
    3. Chen G,
    4. Xu Y,
    5. Huang B,
    6. Chen Z,
    7. et al.
    (2012) Prevalence and risk factors associated with prehypertension and hypertension in the Chinese She population. Kidney Blood Press Res 35:305–313.
    OpenUrlPubMed
  18. ↵
    1. Zhang R,
    2. Deng R,
    3. Shen P,
    4. Fan M,
    5. Leng B,
    6. Zhou Y,
    7. et al.
    (2017) Prehypertension and socioeconomic status:A cross-sectional study in Chongqing, China. Clin Exp Hypertens 39:774–780.
    OpenUrl
  19. ↵
    1. Chen C,
    2. Yuan Z
    (2018) Prevalence and risk factors for prehypertension and hypertension among adults in Central China from 2000-2011. Clin Exp Hypertens 40:734–743.
    OpenUrl
  20. ↵
    1. Hu L,
    2. Huang X,
    3. You C,
    4. Li J,
    5. Hong K,
    6. Li P,
    7. et al.
    (2017) Prevalence and risk factors of prehypertension and hypertension in Southern China. Plos One 12:e170238.
    OpenUrl
  21. ↵
    1. Xu T,
    2. Liu J,
    3. Zhu G,
    4. Liu J,
    5. Han S
    (2016) Prevalence of prehypertension and associated risk factors among Chinese adults from a large-scale multi-ethnic population survey. BMC Public Health 16:775.
    OpenUrl
  22. ↵
    1. Mallik D,
    2. Mukhopadhyay DK,
    3. Kumar P,
    4. Sinhababu A
    (2014) Hypertension, Prehypertension and Normotension among Police Personnel in a District of West Bengal, India. J Assoc Physicians India 62:12–16.
    OpenUrl
  23. ↵
    1. Peltzer K,
    2. Pengpid S,
    3. Sychareun V,
    4. Ferrer A,
    5. Low WY,
    6. Huu TN,
    7. et al.
    (2017) Prehypertension and psychosocial risk factors among university students in ASEAN countries. BMC Cardiovasc Disord 17:230.
    OpenUrl
  24. ↵
    1. Aldiab A,
    2. Shubair MM,
    3. Al-Zahrani JM,
    4. Aldossari KK,
    5. Al-Ghamdi S,
    6. Househ M,
    7. et al.
    (2018) Prevalence of hypertension and prehypertension and its associated cardioembolic risk factors;a population based cross-sectional study in Alkharj, Saudi Arabia. BMC Public Health 18:1327.
    OpenUrl
  25. ↵
    1. Mengistu MD
    (2014) Pattern of blood pressure distribution and prevalence of hypertension and prehypertension among adults in Northern Ethiopia:disclosing the hidden burden. BMC Cardiovasc Disord 14:33.
    OpenUrlCrossRefPubMed
  26. ↵
    1. Kayima J,
    2. Nankabirwa J,
    3. Sinabulya I,
    4. Nakibuuka J,
    5. Zhu X,
    6. Rahman M,
    7. et al.
    (2015) Determinants of hypertension in a young adult Ugandan population in epidemiological transition-the MEPI-CVD survey. BMC Public Health 15:830.
    OpenUrlPubMed
  27. ↵
    1. Booth JR,
    2. Li J,
    3. Zhang L,
    4. Chen L,
    5. Muntner P,
    6. Egan B
    (2017) Trends in Prehypertension and Hypertension Risk Factors in US Adults 1999-2012. Hypertension 70:275–284.
    OpenUrl
  28. ↵
    1. Tucker AM,
    2. Lincoln AE,
    3. Vogel RA,
    4. Black HR,
    5. Dunn RE,
    6. Wilson PW,
    7. et al.
    (2015) Lack of blood pressure difference by race in professional American football players. J Am Soc Hypertens 9:370–374.
    OpenUrl
  29. ↵
    1. Zhang H,
    2. Deng M,
    3. Xu H,
    4. Wang H,
    5. Song F,
    6. Bao C,
    7. et al.
    (2017) Pre- and undiagnosed-hypertension in urban Chinese adults:a population-based cross-sectional study. J Hum Hypertens 31:263–269.
    OpenUrl
    1. Parthaje PM,
    2. Unnikrishnan B,
    3. Thankappan KR,
    4. Thapar R,
    5. Fatt QK,
    6. Oldenburg B
    (2016) Prevalence and Correlates of Prehypertension Among Adults in Urban South India. Asia Pac J Public Health 28(1 Suppl):93S–101S.
    OpenUrlCrossRefPubMed
  31. ↵
    1. Biswas T,
    2. Islam MS,
    3. Linton N,
    4. Rawal LB
    (2016) Socio-economic inequality of chronic non-communicable diseases in Bangladesh. PLOS One 11:e167140.
    OpenUrl
  32. ↵
    1. Shen Y,
    2. Chang C,
    3. Zhang J,
    4. Jiang Y,
    5. Ni B,
    6. Wang Y
    (2017) Prevalence and risk factors associated with hypertension and prehypertension in a working population at high altitude in China:a cross-sectional study. Environ Health Prev Med 22:19.
    OpenUrlPubMed
  33. ↵
    1. Isezuo SA,
    2. Sabir AA,
    3. Ohwovorilole AE,
    4. Fasanmade OA
    (2011) Prevalence, associated factors and relationship between prehypertension and hypertension:a study of two ethnic African populations in Northern Nigeria. J Hum Hypertens 25:224–230.
    OpenUrlPubMed
  34. ↵
    1. Ma M,
    2. Tan X,
    3. Zhu S
    (2017) Prehypertension and its optimal indicator among adults in Hubei Province, Central China 2013-2015. Clin Exp Hypertens 39:532–538.
    OpenUrl
  35. ↵
    1. Yang BY,
    2. Qian ZM,
    3. Vaughn MG,
    4. Howard SW,
    5. Pemberton JP,
    6. Ma H,
    7. et al.
    (2018) Overweight modifies the association between long-term ambient air pollution and prehypertension in Chinese adults:the 33 Communities Chinese Health Study. Environ Health 17:57.
    OpenUrl
  36. ↵
    1. Liang J,
    2. Wang Y,
    3. Dou L,
    4. Li H,
    5. Liu X,
    6. Qiu Q,
    7. et al.
    (2015) Neck circumference and prehypertension:the cardiometabolic risk in Chinese study. J Hypertens 33:275–278.
    OpenUrl
  37. ↵
    1. Wu IH,
    2. Wu JS,
    3. Sun ZJ,
    4. Lu FH,
    5. Chang CS,
    6. Chang CJ,
    7. et al.
    (2016) Higher serum uric acid level increases risk of prehypertension in subjects with normal glucose tolerance, but not pre-diabetes and diabetes. J Hum Hypertens 30:479–482.
    OpenUrl
  38. ↵
    1. Sidoti A,
    2. Nigrelli S,
    3. Rosati A,
    4. Bigazzi R,
    5. Caprioli R,
    6. Fanelli R,
    7. et al.
    (2017) Body mass index, fat free mass, uric acid, and renal function as blood pressure levels determinants in young adults. Nephrology (Carlton) 22:279–285.
    OpenUrl
  39. ↵
    1. Peng H,
    2. Ding J,
    3. Peng Y,
    4. Zhang Q,
    5. Xu Y,
    6. Chao X,
    7. et al.
    (2012) Hyperuricemia and microalbuminuria are separately and independently associated with prehypertension among Chinese Han women. Metab Syndr Relat Disord 10:202–208.
    OpenUrlCrossRefPubMed
  40. ↵
    1. Donahue RP,
    2. Stranges S,
    3. Rafalson L,
    4. Dmochowski J,
    5. Dorn J,
    6. Trevisan M
    (2014) Risk factors for prehypertension in the community:a prospective analysis from the Western New York Health Study. Nutr Metab Cardiovasc Dis 24:162–167.
    OpenUrlCrossRefPubMed
  41. ↵
    1. Jung CH,
    2. Jung SH,
    3. Lee B,
    4. Rosenberg M,
    5. Reaven GM,
    6. Kim SH
    (2017) Relationship among age, insulin resistance, and blood pressure. J Am Soc Hypertens 11:359–365.
    OpenUrl
  42. ↵
    1. Wang Y,
    2. Klaric L,
    3. Yu X,
    4. Thaqi K,
    5. Dong J,
    6. Novokmet M,
    7. et al.
    (2016) The association between glycosylation of immunoglobulin G and hypertension:A multiple ethnic cross-sectional study. Medicine (Baltimore) 95:e3379.
    OpenUrl
    1. Yuen J,
    2. Yan Y,
    3. Wong V,
    4. Tam W,
    5. So KW,
    6. Chien WT
    (2018) A physical health profile of youths living with a “Hikikomori”lifestyle. Int J Environ Res Public Health 15:2.
    OpenUrl
  44. ↵
    1. Sun XM,
    2. Yao S,
    3. Hu SJ,
    4. Liu ZY,
    5. Yang YJ,
    6. Yuan ZY,
    7. et al.
    (2016) Short sleep duration is associated with increased risk of pre-hypertension and hypertension in Chinese early middle-aged females. Sleep Breath 20:1355–1362.
    OpenUrl
  45. ↵
    1. Pal GK,
    2. Adithan C,
    3. Dutta TK,
    4. Pal P,
    5. Nanda N,
    6. Syamsundara KA,
    7. et al.
    (2013) Preference for salt contributes to sympathovagal imbalance in the genesis of prehypertension. Eur J Clin Nutr 67:586–591.
    OpenUrlCrossRefPubMed
  46. ↵
    1. Bhat SK,
    2. Beilin LJ,
    3. Robinson M,
    4. Burrows S,
    5. Mori TA
    (2015) Contrasting effects of prenatal life stress on blood pressure and body mass index in young adults. J Hypertens 33:711–719.
    OpenUrl
  47. ↵
    1. Stepanczuk BC,
    2. Dicianno BE,
    3. Webb TS
    (2014) Young adults with spina bifida may have higher occurrence of prehypertension and hypertension. Am J Phys Med Rehabil 93:200–206.
    OpenUrlCrossRefPubMed
  48. ↵
    1. Kawabata Y,
    2. Ekuni D,
    3. Miyai H,
    4. Kataoka K,
    5. Yamane M,
    6. Mizutani S,
    7. et al.
    (2016) Relationship between prehypertension/hypertension and periodontal disease:A prospective cohort study. Am J Hypertens 29:388–396.
    OpenUrlCrossRefPubMed
  49. ↵
    1. Abdi H,
    2. Gharibzadeh S,
    3. Tasdighi E,
    4. Amouzegar A,
    5. Mehran L,
    6. Tohidi M,
    7. et al.
    (2018) Associations between thyroid and blood pressure in euthyroid adults:A 9-year longitudinal study. Horm Metab Res 50:236–241.
    OpenUrl
  50. ↵
    1. Ononamadu CJ,
    2. Ezekwesili CN,
    3. Onyeukwu OF,
    4. Umeoguaju UF,
    5. Ezeigwe OC,
    6. Ihegboro GO
    (2017) Comparative analysis of anthropometric indices of obesity as correlates and potential predictors of risk for hypertension and prehypertension in a population in Nigeria. Cardiovasc J Afr 28:92–99.
    OpenUrl
  51. ↵
    1. Unsal S,
    2. Ozkara A,
    3. Albayrak T,
    4. Ozturk Y,
    5. Beysel S,
    6. Kucukler FK
    (2016) Evaluation of prehypertension and masked hypertension rate among clinically normotensive patients. Clin Exp Hypertens 38:218–224.
    OpenUrl
  52. ↵
    1. Montasser ME,
    2. Douglas JA,
    3. Roy-Gagnon MH,
    4. Van Hout CV,
    5. Weir MR,
    6. Vogel R,
    7. et al.
    (2011) Determinants of blood pressure response to low-salt intake in a healthy adult population. J Clin Hypertens (Greenwich) 13:795–800.
    OpenUrlCrossRefPubMed
  53. ↵
    1. Juraschek SP,
    2. Gelber AC,
    3. Choi HK,
    4. Appel LJ,
    5. Miller ER
    (2016) Effects of the Dietary Approaches to Stop Hypertension (DASH) Diet and Sodium Intake on Serum Uric Acid. Arthritis Rheumatol 68:3002–3009.
    OpenUrl
  54. ↵
    1. Davinelli S,
    2. Scapagnini G
    (2016) Polyphenols:a Promising Nutritional Approach to Prevent or Reduce the Progression of Prehypertension. High Blood Press Cardiovasc Prev 23:197–202.
    OpenUrl
  55. ↵
    1. Hobbs DA,
    2. Kaffa N,
    3. George TW,
    4. Methven L,
    5. Lovegrove JA
    (2012) Blood pressure-lowering effects of beetroot juice and novel beetroot-enriched bread products in normotensive male subjects. Br J Nutr 108:2066–2074.
    OpenUrlCrossRefPubMed
  56. ↵
    1. Ash GI,
    2. Taylor BA,
    3. Thompson PD,
    4. MacDonald HV,
    5. Lamberti L,
    6. Chen MH,
    7. et al.
    (2017) The antihypertensive effects of aerobic versus isometric handgrip resistance exercise. J Hypertens 35:291–299.
    OpenUrl
  57. ↵
    1. Williamson W,
    2. Foster C,
    3. Reid H,
    4. Kelly P,
    5. Lewandowski AJ,
    6. Boardman H,
    7. et al.
    (2016) Will Exercise Advice Be Sufficient for Treatment of Young Adults With Prehypertension and Hypertension?A Systematic Review and Meta-Analysis. Hypertension 68:78–87.
    OpenUrlCrossRef
  58. ↵
    1. Sales AR,
    2. Silva BM,
    3. Neves FJ,
    4. Rocha NG,
    5. Medeiros RF,
    6. Castro RR,
    7. et al.
    (2012) Diet and exercise training reduce blood pressure and improve autonomic modulation in women with prehypertension. Eur J Appl Physiol 112:3369–3378.
    OpenUrlPubMed
  59. ↵
    1. Beck DT,
    2. Martin JS,
    3. Casey DP,
    4. Braith RW
    (2014) Exercise training improves endothelial function in resistance arteries of young prehypertensives. J Hum Hypertens 28:303–309.
    OpenUrlCrossRefPubMed
  60. ↵
    1. Park JE,
    2. Hong S,
    3. Lee M,
    4. Park T,
    5. Kang K,
    6. Jung H,
    7. et al.
    (2014) Randomized, controlled trial of qigong for treatment of prehypertension and mild essential hypertension. Altern Ther Health Med 20:21–30.
    OpenUrl
  61. ↵
    1. Julius S,
    2. Nesbitt SD,
    3. Egan BM,
    4. Weber MA,
    5. Michelson EL,
    6. Kaciroti N,
    7. et al.
    (2006) Feasibility of treating prehypertension with an angiotensin-receptor blocker. N Engl J Med 354:1685–1697.
    OpenUrlCrossRefPubMedWeb of Science
  62. ↵
    1. Luders S,
    2. Schrader J,
    3. Berger J,
    4. Unger T,
    5. Zidek W,
    6. Bohm M,
    7. et al.
    (2008) The PHARAO study:prevention of hypertension with the angiotensin-converting enzyme inhibitor ramipril in patients with high-normal blood pressure:a prospective, randomized, controlled prevention trial of the German Hypertension League. J Hypertens 26:1487–1496.
    OpenUrlCrossRefPubMedWeb of Science
  63. ↵
    1. Bhagatwala J,
    2. Harris RA,
    3. Parikh SJ,
    4. Zhu H,
    5. Huang Y,
    6. Kotak I,
    7. et al.
    (2014) Epithelial sodium channel inhibition by amiloride on blood pressure and cardiovascular disease risk in young prehypertensives. J Clin Hypertens (Greenwich) 16:47–53.
    OpenUrlCrossRefPubMed
  64. ↵
    1. Fuchs SC,
    2. Poli-de-Figueiredo CE,
    3. Figueiredo NJ,
    4. Scala LC,
    5. Whelton PK,
    6. Mosele F,
    7. et al.
    (2016) Effectiveness of Chlorthalidone Plus Amiloride for the Prevention of Hypertension:The PREVER-Prevention Randomized Clinical Trial. J Am Heart Assoc 5:12.
    OpenUrl
  65. ↵
    1. Fuchs FD,
    2. Fuchs SC,
    3. Poli-de-Figueiredo CE,
    4. Figueiredo NJ,
    5. Scala L,
    6. Vilela-Martin JF,
    7. et al.
    (2018) Effectiveness of low-dose diuretics for blood pressure reduction to optimal values in prehypertension:a randomized clinical trial. J Hypertens 36:933–938.
    OpenUrlCrossRefPubMed
  66. ↵
    1. Perez-Pozo SE,
    2. Schold J,
    3. Nakagawa T,
    4. Sanchez-Lozada LG,
    5. Johnson RJ,
    6. Lillo JL
    (2010) Excessive fructose intake induces the features of metabolic syndrome in healthy adult men:role of uric acid in the hypertensive response. Int J Obes (Lond) 34:454–461.
    OpenUrlCrossRefPubMed
  67. ↵
    1. Kim JK,
    2. Kim KA,
    3. Choi HM,
    4. Park SK,
    5. Stebbins CL
    (2018) Grape Seed Extract Supplementation Attenuates the Blood Pressure Response to Exercise in Prehypertensive Men. J Med Food 21:445–453.
    OpenUrl
  68. ↵
    1. Huang Y,
    2. Su L,
    3. Cai X,
    4. Mai W,
    5. Wang S,
    6. Hu Y,
    7. et al.
    (2014) Association of all-cause and cardiovascular mortality with prehypertension:a meta-analysis. Am Heart J 167:160–168.
    OpenUrlCrossRefPubMed
  69. ↵
    1. Santos AB,
    2. Gupta DK,
    3. Bello NA,
    4. Gori M,
    5. Claggett B,
    6. Fuchs FD,
    7. et al.
    (2016) Prehypertension is Associated With Abnormalities of Cardiac Structure and Function in the Atherosclerosis Risk in Communities Study. Am J Hypertens 29:568–574.
    OpenUrlCrossRefPubMed
  70. ↵
    1. Ennis IL,
    2. Pinilla OA,
    3. Escudero EM
    (2016) [Early cardiovascular changes in young people with normal and normal-high blood pressure]. Hipertens Riesgo Vasc 33:86–92.
    OpenUrl
    1. Markus MR,
    2. Stritzke J,
    3. Lieb W,
    4. Mayer B,
    5. Luchner A,
    6. Doring A,
    7. et al.
    (2008) Implications of persistent prehypertension for ageing-related changes in left ventricular geometry and function:the MONICA/KORA Augsburg study. J Hypertens 26:2040–2049.
    OpenUrlCrossRefPubMedWeb of Science
  72. ↵
    1. Pannarale G,
    2. Moroni C,
    3. Acconcia MC,
    4. Pannitteri G,
    5. Truscelli G,
    6. Valente L,
    7. et al.
    (2017) The natural history of prehypertension. A 20-year follow-up. Eur Rev Med Pharmacol Sci 21:1329–1334.
    OpenUrl
  73. ↵
    1. Huang Y,
    2. Cai X,
    3. Li Y,
    4. Su L,
    5. Mai W,
    6. Wang S,
    7. et al.
    (2014) Prehypertension and the risk of stroke:a meta-analysis. Neurology 82:1153–1161.
    OpenUrlCrossRefPubMed
  74. ↵
    1. Rubio-Guerra AF,
    2. Garro-Almendaro AK,
    3. Lozano-Nuevo JJ,
    4. Arana-Pazos KC,
    5. Duran-Salgado MB,
    6. Morales-Lopez H
    (2018) Prehypertension is associated with peripheral arterial disease and low ankle-brachial index. Indian Heart J 70:502–505.
    OpenUrl
  75. ↵
    1. Zhang JX,
    2. Zhu GP,
    3. Zhang BL,
    4. Cheng YY
    (2017) Elevated serum retinol-binding protein 4 levels are correlated with blood pressure in prehypertensive Chinese. J Hum Hypertens 31:611–615.
    OpenUrlCrossRefPubMed
  76. ↵
    1. Piaditis G,
    2. Markou A,
    3. Papanastasiou L,
    4. Androulakis II,
    5. Kaltsas G
    (2015) Progress in aldosteronism:a review of the prevalence of primary aldosteronism in pre-hypertension and hypertension. Eur J Endocrinol 172:R191–R203.
    OpenUrlAbstract/FREE Full Text
  77. ↵
    1. Tsimihodimos V,
    2. Gonzalez-Villalpando C,
    3. Meigs JB,
    4. Ferrannini E
    (2018) Hypertension and Diabetes Mellitus:Coprediction and Time Trajectories. Hypertension 71:422–428.
    OpenUrlPubMed
  78. ↵
    1. Wang Q,
    2. Huang J,
    3. Sun Y,
    4. Zhang W,
    5. Gao Y,
    6. Yao W,
    7. et al.
    (2018) Association of microalbuminuria with diabetes is stronger in people with prehypertension compared to those with ideal blood pressure. Nephrology (Carlton) 23:690–696.
    OpenUrl
  79. ↵
    1. Yi H,
    2. Zhang WZ,
    3. Zhang H,
    4. Chen YH,
    5. Zhou MC
    (2017) Subclinical target organ damage in normotensive and prehypertensive patients. Minerva Cardioangiol 65:16–23.
    OpenUrl
  80. ↵
    1. Bo S,
    2. Gruden G,
    3. Charbonnier E,
    4. Martorana M,
    5. Gambino R,
    6. Cassader M,
    7. et al.
    (2014) High-normal blood pressure and impaired renal function. A prospective study in a population-based cohort. Minerva Med 105:211–219.
    OpenUrl
  81. ↵
    1. Li Y,
    2. Xia P,
    3. Xu L,
    4. Wang Y,
    5. Chen L
    (2016) A Meta-Analysis on Prehypertension and Chronic Kidney Disease. PLOS One 11:e156575.
    OpenUrl
  82. ↵
    1. Xue H,
    2. Wang J,
    3. Hou J,
    4. Li J,
    5. Gao J,
    6. Chen S,
    7. et al.
    (2015) Prehypertension and chronic kidney disease in chinese population:Four-year follow-up study. PLOS One 10:e144438.
    OpenUrl
  83. ↵
    1. Lei Q,
    2. Zhou X,
    3. Zhou YH,
    4. Mai CY,
    5. Hou MM,
    6. Lv LJ,
    7. et al.
    (2016) Prehypertension During Normotensive Pregnancy and Postpartum Clustering of Cardiometabolic Risk Factors:A Prospective Cohort Study. Hypertension 68:455–463.
    OpenUrl
  84. ↵
    1. He D,
    2. Wu S,
    3. Zhao H,
    4. Zheng Z,
    5. Zhang W
    (2018) High normal blood pressure in early pregnancy also contribute to early onset preeclampsia and severe preeclampsia. Clin Exp Hypertens 40:539–546.
    OpenUrl
  85. ↵
    1. Wikstrom AK,
    2. Gunnarsdottir J,
    3. Nelander M,
    4. Simic M,
    5. Stephansson O,
    6. Cnattingius S
    (2016) Prehypertension in Pregnancy and Risks of Small for Gestational Age Infant and Stillbirth. Hypertension 67:640–646.
    OpenUrl
  86. ↵
    1. Moinuddin A,
    2. Gupta R,
    3. Saxena Y
    (2016) Autonomic function tests in prehypertensive young adult males of Uttarakhand Region. Indian J Physiol Pharmacol 60:45–51.
    OpenUrl
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