The association between plasma homocysteine level and metabolic syndrome: A record-based study of Saudi patients attending King Abdulaziz Medical City in Riyadh, Saudi Arabia

Abdulkarim Saeed; Mujahid Al Shehri; Abdulghani Al Saleb; Fatmah Othman; Mohammed Al Hazmi; Faris Al Amri; Mazen Ferwana; Mohammed Z. Al Yousef; Maha Al Turki

doi:10.15537/smj.2020.9.25273

References

↵
1. Zendjabil M,
2. Abbou O,
3. Chellouai Z
(2017) Association between metabolic ndrome and hyperhomocysteinemia in an Algerian population. Ann Pharm Fr 75:54–58.
OpenUrl
↵
1. Škovierová H,
2. Vidomanová E,
3. Mahmood S,
4. Sopková J,
5. Drgová A,
6. Červeňová T,
7. et al.
(2016) The molecular and cellular effect of homocysteine metabolism imbalance on human health. Int J Mol Sci 17:1733.
OpenUrl
↵
1. Zhao MJ,
2. Yang YH,
3. Zhou SJ,
4. Yuan D,
5. Lu WH,
6. Xiao-wei L,
7. et al.
(2016) Serum homocysteine and metabolic syndrome in middle-aged and elderly men. Zhonghua Nan Ke Xue 22:138–142.
OpenUrl
↵
1. Saklayen MG
(2018) The global epidemic of the metabolic syndrome. Curr Hypertens Rep 20:12.
OpenUrl CrossRef PubMed
↵
1. Gluvic Z,
2. Zaric B,
3. Resanovic I,
4. et al.
(2017) Link between metabolic syndrome and insulin resistance. Curr Vasc Pharmacol 15:30–39.
OpenUrl
↵
1. Gurka MJ,
2. Guo Y,
3. Filipp SL,
4. DeBoer MD
(2018) Metabolic syndrome severity is significantly associated with future coronary heart disease in type 2 diabetes. Cardiovasc Diabetol 17:17.
OpenUrl PubMed
↵
1. Catena C,
2. Colussi G,
3. Nait F,
4. Capobianco F,
5. Sechi L
(2015) Elevated homocysteine levels are associated with the metabolic syndrome and cardiovascular events in hypertensive patients. Am J Hypertens 28:943–950.
OpenUrl CrossRef PubMed
↵
1. Sreckovic B,
2. Sreckovic VD,
3. Soldatovic I,
4. et al.
(2017) Homocysteine is a marker for metabolic syndrome and atherosclerosis. Diabetes Metab Syndr 11:179–182.
OpenUrl
↵
1. Zendjabil M,
2. Abbou O,
3. Chellouai Z
(2017) Association entre syndrome métabolique et hyperhomocystéinémie dans une population algérienne [Association between metabolic syndrome and hyperhomocysteinemia in an Algerian population]. Ann Pharm Fr 75:54–58.
OpenUrl
↵
1. Alberti KG,
2. Zimmet P,
3. Shaw J
(2005) The metabolic syndrome-a new worldwide definition. The Lancet 366:1059–1062.
OpenUrl
↵
1. Ferri FF
, ed (2012) Ferri's Clinical Advisor, Laboratory tests and interpretation of results (Elsevier Mosby, USA), 1st ed.
↵
1. Whelton PK,
2. Carey RM,
3. Aronow WS,
4. Casey DE Jr,
5. Collins KJ,
6. Dennison Himmelfarb C,
7. et al.
(2018) 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults:Executive Summary:A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension 71:1269–1324.
OpenUrl CrossRef PubMed
↵
1. American Diabetes Association
Type 2 diabetes, cited 2019, Available from: https://www.diabetes.org/a1c/diagnosis.
↵
1. Whelton PK,
2. Carey RM,
3. Aronow WS,
4. Casey DE Jr,
5. Collins KJ,
6. Dennison Himmelfarb C,
7. et al.
(2018) 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults:Executive Summary:A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension 71:1269–1324.
OpenUrl CrossRef PubMed
↵
1. Guo S,
2. Pang H,
3. Guo H,
4. Zhang M,
5. He J,
6. Yan Y,
7. et al.
(2015) Ethnic differences in the prevalence of high homocysteine levels among low-income rural Kazakh and Uyghur adults in far western China and its implications for preventive public health. Int J Environ Res Public Health 12:5373–5385.
OpenUrl
↵
1. Omoike OE,
2. Paul TK,
3. Ridner SL,
4. Awasthi M,
5. Harirforoosh S,
6. Mamudu HM
(2020) Association between smoking status and homocysteine levels and possible effect modification by cholesterol and oestradiol. Biomarkers 25:126–130.
OpenUrl
↵
1. Momin M,
2. Fan F,
3. Li J,
4. Qin X,
5. Jia J,
6. Qi L,
7. et al.
(2017) Associations of plasma homocysteine levels with peripheral systolic blood pressure and noninvasive central systolic blood pressure in a community-based Chinese population. Sci Rep 7:6316.
OpenUrl
↵
1. Ganguly P,
2. Alam SF
(2015) Role of homocysteine in the development of cardiovascular disease. Nutr J 14:6.
OpenUrl PubMed
↵
1. Kumar A,
2. Palfrey HA,
3. Pathak R,
4. Kadowitz PJ,
5. Gettys TW,
6. Murthy SN
(2017) The metabolism and significance of homocysteine in nutrition and health. Nutr Metab (Lond) 14:78.
OpenUrl CrossRef
↵
1. Barroso M,
2. Handy D,
3. Castro R
(2017) The link between hyperhomocysteinemia and hypomethylation:Implications for cardiovascular disease. Journal of Inborn Errors of Metabolism and Screening 5:e160024.
OpenUrl
↵
1. Amin HK,
2. El-Sayed MI,
3. Leheta OF
(2016) Homocysteine as a predictive biomarker in early diagnosis of renal failure susceptibility and prognostic diagnosis for end stages renal disease. Ren Fail 38:1267–1275.
OpenUrl
↵
1. Cohen E,
2. Margalit I,
3. Shochat T,
4. Goldberg E,
5. Krause I
(2019) Gender differences in homocysteine concentrations, a population-based cross-sectional study. Nutr Metab Cardiovasc Dis 29:9–14.
OpenUrl
↵
1. Biswas S,
2. Haque R,
3. Uddin N,
4. Saha A,
5. Sultan K,
6. Khondker,
7. et al.
(2019) Raised serum homocysteine level is associated with hypertension. Bangladesh Journal of Medical Biochemistry 11:22–25.
OpenUrl
↵
1. Guoqiang Gu,
2. Ruitao Liu,
3. Yaqing Zhou,
4. Ying Zhang,
5. Wei Cui
(2016) Correlation between homocysteine levels and 24-hambulatory blood pressure variability in Chinese hypertensive patients. Int J Clin Exp Med 9:11715–11722.
OpenUrl
↵
1. Lai WK,
2. Kan MY
(2015) Homocysteine-induced endothelial dysfunction. Ann Nutr Metab 67:1–12.
OpenUrl CrossRef PubMed
↵
1. Feng X,
2. Xu Y
(2017) Hyperhomocysteinemia as a metabolic risk factor for glucose intolerance among high-risk groups of chinese adults. Med Sci Monit 23:2775–2781.
OpenUrl
1. Platt DE,
2. Hariri E,
3. Salameh P,
4. Merhi M,
5. Sabbah N,
6. Helou M,
7. et al.
(2017) Type II diabetes mellitus and hyperhomocysteinemia:a complex interaction. Diabetol Metab Syndr 9:19.
OpenUrl
1. Gong T,
2. Wang J,
3. Yang M,
4. Shao Y,
5. Liu J,
6. Wu Q,
7. et al.
(2016) Serum homocysteine level and gestational diabetes mellitus:A meta-analysis. J Diabetes Investig 7:622–628.
OpenUrl PubMed
1. Ala OA,
2. Akintunde AA,
3. Ikem RT,
4. Kolawole BA,
5. Ala OO,
6. Adedeji TA
(2017) Association between insulin resistance and total plasma homocysteine levels in type 2 diabetes mellitus patients in south west Nigeria. Diabetes Metab Syndr 11(Suppl2):S803–S809.
OpenUrl
↵
1. Yang N,
2. Yao Z,
3. Miao L,
4. Liu J,
5. Gao X,
6. Fan H,
7. et al.
(2015) Novel clinical evidence of an association between homocysteine and insulin resistance in patients with hypothyroidism or subclinical hypothyroidism. PLoS One 10:e0125922.
OpenUrl
↵
1. Li D,
2. Liu HX,
3. Fang YY,
4. et al.
(2018) Hyperhomocysteinemia in polycystic ovary syndrome:decreased betaine-homocysteine methyltransferase and cystathionine ?-synthase-mediated homocysteine metabolism. Reprod Biomed Online 37:234–241.
OpenUrl
↵
1. Meo SA
(2016) Prevalence and future prediction of type 2 diabetes mellitus in the Kingdom of Saudi Arabia:A systematic review of published studies. J Pak Med Assoc 66:722–725.
OpenUrl
↵
1. Al-Hussaini A,
2. Bashir MS,
3. Khormi M,
4. et al.
(2019) Overweight and obesity among Saudi children and adolescents:Where do we stand today? Saudi J Gastroenterol 25:229–235.
OpenUrl
↵
1. Ranasinghe P,
2. Mathangasinghe Y,
3. Jayawardena R,
4. Hills AP,
5. Misra A
(2017) Prevalence and trends of metabolic syndrome among adults in the Asia-Pacific region:a systematic review. BMC Public Health 17:101.
OpenUrl
↵
1. Shin S,
2. Jee H
(2020) Prevalence of metabolic syndrome in the Gulf Cooperation Council countries:meta-analysis of cross-sectional studies. J Exerc Rehabil 16:27–35.
OpenUrl
↵
1. Devers MC,
2. Campbell S,
3. Simmons D
(2016) Influence of age on the prevalence and components of the metabolic syndrome and the association with cardiovascular disease. BMJ Open Diabetes Res Care 4:e000195.
OpenUrl Abstract/FREE Full Text
↵
1. Al-Rubeaan K,
2. Al-Manaa H,
3. Khoja T,
4. Ahmad N,
5. Al-Sharqawi A,
6. Siddiqui K,
7. et al.
(2014) The Saudi Abnormal Glucose Metabolism and Diabetes Impact Study (SAUDI-DM). Ann Saudi Med 34:465–475.
OpenUrl
↵
1. Al-Rubean K,
2. Youssef AM,
3. AlFarsi Y,
4. Al-Sharqawi AH,
5. Bawazeer N,
6. AlOtaibi MT,
7. et al.
(2017) Anthropometric cutoff values for predicting metabolic syndrome in a Saudi community:from the SAUDI-DM study. Ann Saudi Med 37:21–30.
OpenUrl
↵
1. CibičkováĽ Langová K,
2. Vaverková H,
3. Kubíčková V,
4. Karásek D
(2017) Correlation of uric acid levels and parameters of metabolic syndrome. Physiol Res 66:481–487.
OpenUrl
↵
1. Kanbay M,
2. Jensen T,
3. Solak Y,
4. Le M,
5. Roncal-Jimenez C,
6. Rivard C,
7. et al.
(2016) Uric acid in metabolic syndrome:From an innocent bystander to a central player. Eur J Intern Med 29:3–8.
OpenUrl CrossRef PubMed
↵
1. Sun HL,
2. Pei D,
3. Lue KH,
4. Chen YL
(2015) Uric acid levels can predict metabolic syndrome and hypertension in adolescents:a 10-year longitudinal study. PloS One 10:e0143786.
OpenUrl

In this issue

Download PDF

Email Article

Citation Tools

Bookmark this article

Cited By...

No citing articles found.

Google Scholar

More in this TOC Section

Show more Original Article

Keywords

[1] ↵
Zendjabil M,
Abbou O,
Chellouai Z
(2017) Association between metabolic ndrome and hyperhomocysteinemia in an Algerian population. Ann Pharm Fr 75:54–58.
OpenUrl

[2] Zendjabil M,

[3] Abbou O,

[4] Chellouai Z

[5] ↵
Škovierová H,
Vidomanová E,
Mahmood S,
Sopková J,
Drgová A,
Červeňová T,
et al.
(2016) The molecular and cellular effect of homocysteine metabolism imbalance on human health. Int J Mol Sci 17:1733.
OpenUrl

[6] Škovierová H,

[7] Vidomanová E,

[8] Mahmood S,

[9] Sopková J,

[10] Drgová A,

[11] Červeňová T,

[12] et al.

[13] ↵
Zhao MJ,
Yang YH,
Zhou SJ,
Yuan D,
Lu WH,
Xiao-wei L,
et al.
(2016) Serum homocysteine and metabolic syndrome in middle-aged and elderly men. Zhonghua Nan Ke Xue 22:138–142.
OpenUrl

[14] Zhao MJ,

[15] Yang YH,

[16] Zhou SJ,

[17] Yuan D,

[18] Lu WH,

[19] Xiao-wei L,

[20] et al.

[21] ↵
Saklayen MG
(2018) The global epidemic of the metabolic syndrome. Curr Hypertens Rep 20:12.
OpenUrl CrossRef PubMed

[22] Saklayen MG

[23] ↵
Gluvic Z,
Zaric B,
Resanovic I,
et al.
(2017) Link between metabolic syndrome and insulin resistance. Curr Vasc Pharmacol 15:30–39.
OpenUrl

[24] Gluvic Z,

[25] Zaric B,

[26] Resanovic I,

[27] et al.

[28] ↵
Gurka MJ,
Guo Y,
Filipp SL,
DeBoer MD
(2018) Metabolic syndrome severity is significantly associated with future coronary heart disease in type 2 diabetes. Cardiovasc Diabetol 17:17.
OpenUrl PubMed

[29] Gurka MJ,

[30] Guo Y,

[31] Filipp SL,

[32] DeBoer MD

[33] ↵
Catena C,
Colussi G,
Nait F,
Capobianco F,
Sechi L
(2015) Elevated homocysteine levels are associated with the metabolic syndrome and cardiovascular events in hypertensive patients. Am J Hypertens 28:943–950.
OpenUrl CrossRef PubMed

[34] Catena C,

[35] Colussi G,

[36] Nait F,

[37] Capobianco F,

[38] Sechi L

[39] ↵
Sreckovic B,
Sreckovic VD,
Soldatovic I,
et al.
(2017) Homocysteine is a marker for metabolic syndrome and atherosclerosis. Diabetes Metab Syndr 11:179–182.
OpenUrl

[40] Sreckovic B,

[41] Sreckovic VD,

[42] Soldatovic I,

[43] et al.

[44] ↵
Zendjabil M,
Abbou O,
Chellouai Z
(2017) Association entre syndrome métabolique et hyperhomocystéinémie dans une population algérienne [Association between metabolic syndrome and hyperhomocysteinemia in an Algerian population]. Ann Pharm Fr 75:54–58.
OpenUrl

[45] Zendjabil M,

[46] Abbou O,

[47] Chellouai Z

[48] ↵
Alberti KG,
Zimmet P,
Shaw J
(2005) The metabolic syndrome-a new worldwide definition. The Lancet 366:1059–1062.
OpenUrl

[49] Alberti KG,

[50] Zimmet P,

[51] Shaw J

[52] ↵
Ferri FF
, ed (2012) Ferri's Clinical Advisor, Laboratory tests and interpretation of results (Elsevier Mosby, USA), 1st ed.

[53] Ferri FF

[54] ↵
Whelton PK,
Carey RM,
Aronow WS,
Casey DE Jr,
Collins KJ,
Dennison Himmelfarb C,
et al.
(2018) 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults:Executive Summary:A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension 71:1269–1324.
OpenUrl CrossRef PubMed

[55] Whelton PK,

[56] Carey RM,

[57] Aronow WS,

[58] Casey DE Jr,

[59] Collins KJ,

[60] Dennison Himmelfarb C,

[61] et al.

[62] ↵
American Diabetes Association
Type 2 diabetes, cited 2019, Available from: https://www.diabetes.org/a1c/diagnosis.

[63] American Diabetes Association

[64] ↵
Whelton PK,
Carey RM,
Aronow WS,
Casey DE Jr,
Collins KJ,
Dennison Himmelfarb C,
et al.
(2018) 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults:Executive Summary:A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension 71:1269–1324.
OpenUrl CrossRef PubMed

[65] Whelton PK,

[66] Carey RM,

[67] Aronow WS,

[68] Casey DE Jr,

[69] Collins KJ,

[70] Dennison Himmelfarb C,

[71] et al.

[72] ↵
Guo S,
Pang H,
Guo H,
Zhang M,
He J,
Yan Y,
et al.
(2015) Ethnic differences in the prevalence of high homocysteine levels among low-income rural Kazakh and Uyghur adults in far western China and its implications for preventive public health. Int J Environ Res Public Health 12:5373–5385.
OpenUrl

[73] Guo S,

[74] Pang H,

[75] Guo H,

[76] Zhang M,

[77] He J,

[78] Yan Y,

[79] et al.

[80] ↵
Omoike OE,
Paul TK,
Ridner SL,
Awasthi M,
Harirforoosh S,
Mamudu HM
(2020) Association between smoking status and homocysteine levels and possible effect modification by cholesterol and oestradiol. Biomarkers 25:126–130.
OpenUrl

[81] Omoike OE,

[82] Paul TK,

[83] Ridner SL,

[84] Awasthi M,

[85] Harirforoosh S,

[86] Mamudu HM

[87] ↵
Momin M,
Fan F,
Li J,
Qin X,
Jia J,
Qi L,
et al.
(2017) Associations of plasma homocysteine levels with peripheral systolic blood pressure and noninvasive central systolic blood pressure in a community-based Chinese population. Sci Rep 7:6316.
OpenUrl

[88] Momin M,

[89] Fan F,

[90] Li J,

[91] Qin X,

[92] Jia J,

[93] Qi L,

[94] et al.

[95] ↵
Ganguly P,
Alam SF
(2015) Role of homocysteine in the development of cardiovascular disease. Nutr J 14:6.
OpenUrl PubMed

[96] Ganguly P,

[97] Alam SF

[98] ↵
Kumar A,
Palfrey HA,
Pathak R,
Kadowitz PJ,
Gettys TW,
Murthy SN
(2017) The metabolism and significance of homocysteine in nutrition and health. Nutr Metab (Lond) 14:78.
OpenUrl CrossRef

[99] Kumar A,

[100] Palfrey HA,

[101] Pathak R,

[102] Kadowitz PJ,

[103] Gettys TW,

[104] Murthy SN

[105] ↵
Barroso M,
Handy D,
Castro R
(2017) The link between hyperhomocysteinemia and hypomethylation:Implications for cardiovascular disease. Journal of Inborn Errors of Metabolism and Screening 5:e160024.
OpenUrl

[106] Barroso M,

[107] Handy D,

[108] Castro R

[109] ↵
Amin HK,
El-Sayed MI,
Leheta OF
(2016) Homocysteine as a predictive biomarker in early diagnosis of renal failure susceptibility and prognostic diagnosis for end stages renal disease. Ren Fail 38:1267–1275.
OpenUrl

[110] Amin HK,

[111] El-Sayed MI,

[112] Leheta OF

[113] ↵
Cohen E,
Margalit I,
Shochat T,
Goldberg E,
Krause I
(2019) Gender differences in homocysteine concentrations, a population-based cross-sectional study. Nutr Metab Cardiovasc Dis 29:9–14.
OpenUrl

[114] Cohen E,

[115] Margalit I,

[116] Shochat T,

[117] Goldberg E,

[118] Krause I

[119] ↵
Biswas S,
Haque R,
Uddin N,
Saha A,
Sultan K,
Khondker,
et al.
(2019) Raised serum homocysteine level is associated with hypertension. Bangladesh Journal of Medical Biochemistry 11:22–25.
OpenUrl

[120] Biswas S,

[121] Haque R,

[122] Uddin N,

[123] Saha A,

[124] Sultan K,

[125] Khondker,

[126] et al.

[127] ↵
Guoqiang Gu,
Ruitao Liu,
Yaqing Zhou,
Ying Zhang,
Wei Cui
(2016) Correlation between homocysteine levels and 24-hambulatory blood pressure variability in Chinese hypertensive patients. Int J Clin Exp Med 9:11715–11722.
OpenUrl

[128] Guoqiang Gu,

[129] Ruitao Liu,

[130] Yaqing Zhou,

[131] Ying Zhang,

[132] Wei Cui

[133] ↵
Lai WK,
Kan MY
(2015) Homocysteine-induced endothelial dysfunction. Ann Nutr Metab 67:1–12.
OpenUrl CrossRef PubMed

[134] Lai WK,

[135] Kan MY

[136] ↵
Feng X,
Xu Y
(2017) Hyperhomocysteinemia as a metabolic risk factor for glucose intolerance among high-risk groups of chinese adults. Med Sci Monit 23:2775–2781.
OpenUrl

[137] Feng X,

[138] Xu Y

[139] Platt DE,
Hariri E,
Salameh P,
Merhi M,
Sabbah N,
Helou M,
et al.
(2017) Type II diabetes mellitus and hyperhomocysteinemia:a complex interaction. Diabetol Metab Syndr 9:19.
OpenUrl

[140] Platt DE,

[141] Hariri E,

[142] Salameh P,

[143] Merhi M,

[144] Sabbah N,

[145] Helou M,

[146] et al.

[147] Gong T,
Wang J,
Yang M,
Shao Y,
Liu J,
Wu Q,
et al.
(2016) Serum homocysteine level and gestational diabetes mellitus:A meta-analysis. J Diabetes Investig 7:622–628.
OpenUrl PubMed

[148] Gong T,

[149] Wang J,

[150] Yang M,

[151] Shao Y,

[152] Liu J,

[153] Wu Q,

[154] et al.

[155] Ala OA,
Akintunde AA,
Ikem RT,
Kolawole BA,
Ala OO,
Adedeji TA
(2017) Association between insulin resistance and total plasma homocysteine levels in type 2 diabetes mellitus patients in south west Nigeria. Diabetes Metab Syndr 11(Suppl2):S803–S809.
OpenUrl

[156] Ala OA,

[157] Akintunde AA,

[158] Ikem RT,

[159] Kolawole BA,

[160] Ala OO,

[161] Adedeji TA

[162] ↵
Yang N,
Yao Z,
Miao L,
Liu J,
Gao X,
Fan H,
et al.
(2015) Novel clinical evidence of an association between homocysteine and insulin resistance in patients with hypothyroidism or subclinical hypothyroidism. PLoS One 10:e0125922.
OpenUrl

[163] Yang N,

[164] Yao Z,

[165] Miao L,

[166] Liu J,

[167] Gao X,

[168] Fan H,

[169] et al.

[170] ↵
Li D,
Liu HX,
Fang YY,
et al.
(2018) Hyperhomocysteinemia in polycystic ovary syndrome:decreased betaine-homocysteine methyltransferase and cystathionine ?-synthase-mediated homocysteine metabolism. Reprod Biomed Online 37:234–241.
OpenUrl

[171] Li D,

[172] Liu HX,

[173] Fang YY,

[174] et al.

[175] ↵
Meo SA
(2016) Prevalence and future prediction of type 2 diabetes mellitus in the Kingdom of Saudi Arabia:A systematic review of published studies. J Pak Med Assoc 66:722–725.
OpenUrl

[176] Meo SA

[177] ↵
Al-Hussaini A,
Bashir MS,
Khormi M,
et al.
(2019) Overweight and obesity among Saudi children and adolescents:Where do we stand today? Saudi J Gastroenterol 25:229–235.
OpenUrl

[178] Al-Hussaini A,

[179] Bashir MS,

[180] Khormi M,

[181] et al.

[182] ↵
Ranasinghe P,
Mathangasinghe Y,
Jayawardena R,
Hills AP,
Misra A
(2017) Prevalence and trends of metabolic syndrome among adults in the Asia-Pacific region:a systematic review. BMC Public Health 17:101.
OpenUrl

[183] Ranasinghe P,

[184] Mathangasinghe Y,

[185] Jayawardena R,

[186] Hills AP,

[187] Misra A

[188] ↵
Shin S,
Jee H
(2020) Prevalence of metabolic syndrome in the Gulf Cooperation Council countries:meta-analysis of cross-sectional studies. J Exerc Rehabil 16:27–35.
OpenUrl

[189] Shin S,

[190] Jee H

[191] ↵
Devers MC,
Campbell S,
Simmons D
(2016) Influence of age on the prevalence and components of the metabolic syndrome and the association with cardiovascular disease. BMJ Open Diabetes Res Care 4:e000195.
OpenUrl Abstract/FREE Full Text

[192] Devers MC,

[193] Campbell S,

[194] Simmons D

[195] ↵
Al-Rubeaan K,
Al-Manaa H,
Khoja T,
Ahmad N,
Al-Sharqawi A,
Siddiqui K,
et al.
(2014) The Saudi Abnormal Glucose Metabolism and Diabetes Impact Study (SAUDI-DM). Ann Saudi Med 34:465–475.
OpenUrl

[196] Al-Rubeaan K,

[197] Al-Manaa H,

[198] Khoja T,

[199] Ahmad N,

[200] Al-Sharqawi A,

[201] Siddiqui K,

[202] et al.

[203] ↵
Al-Rubean K,
Youssef AM,
AlFarsi Y,
Al-Sharqawi AH,
Bawazeer N,
AlOtaibi MT,
et al.
(2017) Anthropometric cutoff values for predicting metabolic syndrome in a Saudi community:from the SAUDI-DM study. Ann Saudi Med 37:21–30.
OpenUrl

[204] Al-Rubean K,

[205] Youssef AM,

[206] AlFarsi Y,

[207] Al-Sharqawi AH,

[208] Bawazeer N,

[209] AlOtaibi MT,

[210] et al.

[211] ↵
CibičkováĽ Langová K,
Vaverková H,
Kubíčková V,
Karásek D
(2017) Correlation of uric acid levels and parameters of metabolic syndrome. Physiol Res 66:481–487.
OpenUrl

[212] CibičkováĽ Langová K,

[213] Vaverková H,

[214] Kubíčková V,

[215] Karásek D

[216] ↵
Kanbay M,
Jensen T,
Solak Y,
Le M,
Roncal-Jimenez C,
Rivard C,
et al.
(2016) Uric acid in metabolic syndrome:From an innocent bystander to a central player. Eur J Intern Med 29:3–8.
OpenUrl CrossRef PubMed

[217] Kanbay M,

[218] Jensen T,

[219] Solak Y,

[220] Le M,

[221] Roncal-Jimenez C,

[222] Rivard C,

[223] et al.

[224] ↵
Sun HL,
Pei D,
Lue KH,
Chen YL
(2015) Uric acid levels can predict metabolic syndrome and hypertension in adolescents:a 10-year longitudinal study. PloS One 10:e0143786.
OpenUrl

[225] Sun HL,

[226] Pei D,

[227] Lue KH,

[228] Chen YL

Main menu

User menu

Search

The association between plasma homocysteine level and metabolic syndrome

A record-based study of Saudi patients attending King Abdulaziz Medical City in Riyadh, Saudi Arabia

References

In this issue

Citation Manager Formats

Related Articles

Cited By...

More in this TOC Section

Similar Articles

Keywords

CONTENT

JOURNAL

AUTHORS

Main menu

User menu

Search

The association between plasma homocysteine level and metabolic syndrome

A record-based study of Saudi patients attending King Abdulaziz Medical City in Riyadh, Saudi Arabia

References

In this issue

Citation Manager Formats

Jump to section

Related Articles

Cited By...

More in this TOC Section

Similar Articles

Keywords

CONTENT

JOURNAL

AUTHORS