Emerging variants of concern in Saudi Arabian SARS-CoV-2 isolates

Abdullah G. Al-Sehemi; Muhammad T. Khan; Shabbir Muhammad

doi:10.15537/smj.2021.42.12.20210630

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Table 1

- Mutations in alpha and beta variants in Saudi Arabian isolates.

VOC Alpha 202012/01 GRY (B.1.1.7)		VOC Beta GH/501Y.V2 (B.1.351+B.1.351.2+B.1.351.3)
Mutations	Frequency	Mutations	Frequency
Spike_A570D	4	Spike_A570D	1
Spike_V70del	4	Spike_V70del	1
Spike_N501Y	4	Spike_P681H	1
Spike_T716I	4	Spike_T716I	1
Spike_Y144del	4	Spike_Y144del	1
Spike_S982A	4	Spike_H69del	1
Spike_P681H	4	Spike_S982A	1
Spike_D614G	4	Spike_D1118H	1
Spike_H69del	4	Spike_D614G	1
Spike_D1118H	4	Spike_N501Y	1
Spike_I402V	2	N_R203K	1
N_S235F	4	N_G204R	1
N_R203K	4	N_D3L	1
N_G204R	4	N_S235F	1
N_D3L	4	NSP2_L39Q	1
NSP2_L39Q	1	NSP3_T183I	1
NSP3_T183I	4	NSP3_I1412T	1
NSP3_T1002I	1	NSP3_A890D	1
NSP3_A890D	4	NSP6_S106del	1
NSP3_I1412T	4	NSP6_F108del	1
NSP6_S106del	4	NSP6_G107del	1
NSP6_F108del	4	NSP12_P323L	1
NSP6_G107del	4	NS8_R52I	1
NSP12_P323L	4	NS8_K68stop	1
NSP14_T516I	1	NS8_Y73C	1
NS8_K68stop	4	NS8_Q27stop	1
NS8_Y73C	4
NS8_Q27stop	4
NS8_R52I	4

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Appendix 1

- All the detected SARS-CoV-2 variant genome mutations.

Query	#Muts	%Muts	#UniqueMuts	#ExistingMuts	%ExistingMuts
hCoV-19/Saudi Arabia/KFSHRC8/2021\|EPI_ISL_2151336\|2021-04-15	26	0.27%	1	25	0.26%
hCoV-19/Saudi Arabia/DM-21-095140A/2021\|EPI_ISL_3236930\|2021-04-06	27	0.28%	0	27	0.28%
hCoV-19/Saudi Arabia/DM-21-110634A/2021\|EPI_ISL_3237047\|2021-04-25	26	0.27%	1	25	0.26%
hCoV-19/Saudi Arabia/DM-21-110332A/2021\|EPI_ISL_3237048\|2021-04-25	26	0.27%	1	25	0.26%
	UniqueMutList	ExistingMutList	Clade	IfExistSpecialChar
hCoV-19/Saudi Arabia/KFSHRC8/2021\|EPI_ISL_2151336\|2021-04-15	(NSP2_L39Q)	(NSP3_T183I,NSP3_A890D,NSP3_I1412T, NSP6_F108del,NSP6_G107del,NSP6_S106del,NSP12_P323L, Spike_A570D,Spike_S982A,Spike_P681H, Spike_D614G,Spike_T716I,Spike_Y144del,Spike_N501Y,Spike_D1118H, Spike_V70del,Spike_H69del,NS8_R52I, NS8_K68stop,NS8_Q27stop,NS8_Y73C,N_S235F,N_D3L,N_G204R,N_R203K)	GRY
hCoV-19/Saudi Arabia/DM-21-110634A/2021\|EPI_ISL_3237047\|2021-04-25	(Spike_I402V)	(NSP3_T183I,NSP3_A890D,NSP3_I1412T,NSP6_F108del, NSP6_G107del,NSP6_S106del,NSP12_P323L, Spike_A570D,Spike_S982A,Spike_P681H,Spike_D614G, Spike_T716I,Spike_Y144del,Spike_N501Y,Spike_D1118H,Spike_V70del, Spike_H69del,NS8_R52I,NS8_K68stop,NS8_Q27stop, NS8_Y73C,N_S235F,N_D3L,N_G204R,N_R203K)	GRY
hCoV-19/Saudi Arabia/DM-21-110332A/2021\|EPI_ISL_3237048\|2021-04-25	(Spike_I402V)	(NSP3_T183I,NSP3_A890D,NSP3_I1412T,NSP6_F108del, NSP6_G107del,NSP6_S106del,NSP12_P323L, Spike_A570D,Spike_S982A,Spike_P681H,Spike_D614G, Spike_T716I,Spike_Y144del, Spike_N501Y,Spike_D1118H,Spike_V70del,Spike_H69del,NS8_R52I, NS8_K68stop,NS8_Q27stop,NS8_Y73C, N_S235F,N_D3L,N_G204R,N_R203K)	GRY	Special char exist.
hCoV-19/Saudi Arabia/DM-21-095140A/2021\|EPI_ISL_3236930\|2021-04-06		(NSP3_T183I,NSP3_A890D,NSP3_T1002I,NSP3_I1412T,NSP6_F108del, NSP6_G107del,NSP6_S106del, NSP12_P323L,NSP14_T516I,Spike_A570D,Spike_S982A,Spike_P681H,Spike_D614G,Spike_T716I, Spike_Y144del,Spike_N501Y,Spike_D1118H,Spike_V70del, Spike_H69del,NS8_R52I,NS8_K68stop,NS8_Q27stop,NS8_Y73C, N_S235F,N_D3L,N_G204R,N_R203K)