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Research ArticleOriginal Article
Open Access

D-dimer as a predictive and prognostic marker among COVID-19 patients

Ahmed M. E. Elkhalifa
Saudi Medical Journal July 2022, 43 (7) 723-729; DOI: https://doi.org/10.15537/smj.2022.43.7.20220213
Ahmed M. E. Elkhalifa
From the Department of Public Health, Health Sciences College, Saudi Electronic University, Riyadh, Kingdom of Saudi Arabia, and from the Department of Haematology, Medical Laboratory Sciences College, University of El Imam El Mahdi, Kosti, Sudan.
MSc, PhD
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    Figure 1

    - Receiver operating characteristic curve analysis of coronavirus disease-19 patients D-dimer. AUC: area under the curve

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    Table 1

    - Coronavirus disease-19 (COVID-19) and comparative subjects’ demographic data, symptoms, and end situation outcomes.

    VariablesCOVID-19Comparative subjects
    Gender
    Female26 (23.2)47 (41.9)
    Male86 (76.8)65 (58.1)
    Age (years)
    <305 (4.5)18 (16.1)
    30-6074 (66.1)45 (40.2)
    >6033 (29.5)49 (43.8)
    Mean±SD51.66±15.354.96±18.6
    Range25-9025-90
    Nationality
    Saudi66 (58.9)73 (65.2)
    Egyptian5 (4.5)3 (2.7)
    Yemeni13 (11.6)10 (8.9)
    Pakistani and Filipina8 (7.1)9 (8)
    Bangladeshi6 (5.4)1 (0.9)
    Indian4 (3.6)2 (1.8)
    others10 (8.9)14 (12.5)
    Symptoms
    Mild and asymptomatic45 (40.1)NA
    Moderate, severe, and critical67 (59.9)NA
    Outcomes situation
    Recovered86 (76.8)NA
    ICU patient17 (15.2)NA
    Deceased9 (8.0)NA

    Values are presented as a number and precentage (%). NA: not available, SD: standard deviation, ICU: intensive care unit

      • View popup
      Table 2

      - Coronavirus disease-19 and comparative subjects’ coagulation parameters and platelets count results on admission.

      ParametersCOVID-19Comparative subjectsT-testP-values
      PT (seconds)13.15±1.4613.30±2.700.4970.620
      APTT (seconds)33.69±5.4230.63±7.473.47<0.001*
      PLTs count (x103)243.38±103.68287.72±89.073.43<0.001*
      D-dimer (μg/mL)1.05±0.710.16±0.0613.70<0.001*
      INR1.08±0.131.15±0.232.820.005*
      • Values are presented as mean ± standard deviation (SD).

      • ↵* Significant, PT: prothrombin time, APTT: activated partial thromboplastin clotting time, PLTs: mean platelets, INR: international normalized ratio

      • View popup
      Table 3

      - Gender and age factors of the coronavirus disease -19 patient’s outcomes situation at the end of the study period (N=112).

      Gender and age factorsOutcomes situationχ2P-values
      RecoveredNon-recovered
      Gender
      Female2421.050.514
      Male7313
      Age
      >60 years old23109.85<0.006*
      ≤60 years old745  

      Values are presented as numbers. *Significant (Fisher exact test)

        • View popup
        Table 4

        - Coronavirus disease-19 patient’s pattern of symptoms on admission and the outcomes of the patient’s situation concerning coagulation parameters and platelet count.

        ParametersPT (seconds)aPTT (seconds)PLTs count (x103)D-dimer (μg/mL)INR
        Moderate, severe, and critical symptoms13.44±1.533.82±5.96243.02±109.891.29±0.821.09±0.14
        Asymptomatic and mild symptoms12.72±1.2933.50±4.56243.91±94.90.75±0.471.05±0.10
        T-test (p-value)3.19 (0.008)*0.321 (0.749)0.044 (0.956)4.293 (<0.001)*0.208 (0.110)
        ICU and deceased patients13.54±2.0334.22±6.58219.78±108.001.47±0.751.10±0.19
        Recovery patients13.02±1.2033.51±5.01251.25±101.940.95±0.721.07±0.10
        T-test (p-value)1.63 (0.104)0.601 (0.549)1.39 (0.165)3.32 (<0.001)*1.07 (0.283)
        • Values are presented as mean ± standard deviation (SD).

        • ↵* Significant, PT: prothrombin time, aPTT: activated partial thromboplastin clotting time, PLTs: mean platelets, INR: international normalized ratio, ICU: intensive care unit

        • View popup
        Table 5

        - Coagulation parameters and platelets count on admission assessment using binary logistic regression analysis

        Coagulation parameters and platelets countBS.E.Exp(B)P-value
        D-dimer (μg/mL)0.0200.0041.021<0.001*
        PLTs count (x103)-0.0060.005.9940.289
        PT (seconds)-0.1450.313.8650.643
        INR-2.1122.805.1210.451
        APTT (seconds)0.0770.0831.0800.356
        Constant-2.7914.117.0610.498
        • ↵* Significant, PT: prothrombin time, APTT: activated partial thromboplastin clotting time, PLTs: mean platelets, INR: international normalized ratio

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      D-dimer as a predictive and prognostic marker among COVID-19 patients
      Ahmed M. E. Elkhalifa
      Saudi Medical Journal Jul 2022, 43 (7) 723-729; DOI: 10.15537/smj.2022.43.7.20220213

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      D-dimer as a predictive and prognostic marker among COVID-19 patients
      Ahmed M. E. Elkhalifa
      Saudi Medical Journal Jul 2022, 43 (7) 723-729; DOI: 10.15537/smj.2022.43.7.20220213
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      Keywords

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