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Research ArticleOriginal Article
Open Access

Cytological patterns of thyroid lesions in Najran, Saudi Arabia

A 5-year retrospective study

Saad M. Alqahtani
Saudi Medical Journal July 2022, 43 (7) 735-742; DOI: https://doi.org/10.15537/smj.2022.43.7.20220223
Saad M. Alqahtani
From the Department of Pathology, College of Medicine, Najran University Hospital, Najran University, Najran, Kingdom of Saudi Arabia.
MD, PhD
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  • Figure 1
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    Figure 1

    - Representative pictures for common benign thyroid lesions: A) 20X benign follicular cells forming monolayered macro-follicles; B) 20X Colloid lesion. C) 10X benign follicular cells with background of colloid; D) 10X Hashimoto’s (lymphocytic) thyroiditis; E) 20X Hashimoto’s (lymphocytic) thyroiditis; and F) 20X Pap stain shows benign follicular cells and hemosiderin laden macrophages.

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    Figure 2

    - Representative pictures for common malignant thyroid lesions: A) 20X Suspicious thyroid neoplasm; B) 10X Suspicious of follicular neoplasm; C) 20X Suspicious of follicular neoplasm; D) X20 anaplastic thyroid carcinoma E) 40X Pap stain papillary thyroid carcinoma, nuclear enlargement, irregular nuclear contour, and powdery chromatin and nuclear grooves; F) 40X papillary thyroid carcinoma with nuclear pseudoinclusion

Tables

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    Table 1

    - The cytological pattern of thyroid lesions in Najran, Saudi Arabia according to Bethesda guidelines.

     Bethesda diagnostic categoriesPathological diagnosisn%
    INon-diagnostic or unsatisfactory (76 cases, 5.6%)Inadequate material765.6
    IIBenign (981, 72.5%)Follicular nodule53539.5
      Colloid nodule15911.8
      Hashimoto’s thyroiditis28721.2
    IIIAtypia of undetermined significance or follicular lesion of undetermined significance (32, 2.4%)Cell atypia322.4
    IVFollicular neoplasms, suspicious follicular neoplasm, or Hürthle cell type (14, 1.0%)Follicular neoplasms or suspicious follicular neoplasm110.8
      Hürthle cell follicular neoplasm30.2
    VSuspicious for malignancy (107, 7.9%)Suspicious for malignancy1077.9
    VIMalignancy (143, 10.6%)Papillary carcinoma13810.2
      Anaplastic carcinoma50.4
      Total1353100
    • View popup
    Table 2

    - The common thyroid lesions in male versus female according to cytology.

    Pathological diagnosisTotal number of casesFemaleMale
      Percentagesn%Percentagesn%
    Follicular nodule53539.541836.739.4511754.4
    Hashimoto’s thyroiditis28721.226623.410.22411.2
    Colloid nodule15911.813812.111.8219.8
    Papillary carcinoma13810.211410.021.2219.8
    Suspicious for malignancy1077.9897.87.9188.4
    Inadequate material765.6675.95.694.2
    Cell atypia322.4292.52.431.4
    Follicular neoplasms or suspicious follicular neoplasm110.8100.90.810.5
    Anaplastic carcinoma50.450.40.210.5
    Hürthle cell follicular neoplasm30.220.20.400.0
    Total  1138100 215100
    • View popup
    Table 3

    - Age distribution of the common thyroid lesions in females.

    Pathological diagnosisTotal number of casesFemaleGroup 1 0-20 YGroup 2 21-40 YGroup 3 41-60 YGroup 4 >60 Y
    Follicular nodule53541809225175
    Hashimoto’s thyroiditis287266013911512
    Colloid nodule159138461694
    Papillary carcinoma138114029832
    Suspicious for malignancy10789011717
    Inadequate material76673171829
    Cell atypia322909200
    Follicular neoplasms or suspicious follicular neoplasm11100271
    Anaplastic carcinoma550500
    Hürthle cell follicular neoplasm320020
    Total135311387365636130
    Percentage0.632.155.911.4  

    Y: years

      • View popup
      Table 4

      - Age distribution of the common thyroid lesions in males.

      Pathological diagnosisTotal number of casesMaleGroup 1 0-20 YGroup 2 21-40 YGroup 3 41-60 YGroup 4 >60 Y
      Follicular nodule5351170673119
      Papillary carcinoma1382401617
      Colloid nodule1592101560
      Hashimoto’s thyroiditis2872104161
      Suspicious for malignancy107180936
      Inadequate material7691125
      Cell atypia3230300
      Follicular neoplasms or suspicious follicular neoplasm1110010
      Hürthle cell follicular neoplasm310010
      Anaplastic Carcinoma500000
      Total135321511156138
      Percentage  0.553.528.417.7

      Y: year

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      1 Jul 2022
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      Cytological patterns of thyroid lesions in Najran, Saudi Arabia
      Saad M. Alqahtani
      Saudi Medical Journal Jul 2022, 43 (7) 735-742; DOI: 10.15537/smj.2022.43.7.20220223

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      Cytological patterns of thyroid lesions in Najran, Saudi Arabia
      Saad M. Alqahtani
      Saudi Medical Journal Jul 2022, 43 (7) 735-742; DOI: 10.15537/smj.2022.43.7.20220223
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      Keywords

      • thyroid
      • FNAC
      • Saudi Arabia
      • cytopathology
      • Bethesda

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