Article Figures & Data
Tables
No. Gender Onset age (y) Previous IS Kidney biopsy Age at RTX (y) No. of RTX infusion Adverse effect Time since last infusion (y) Last visit urine dipstick Outcome and comments 1 F 4 Pred, tac MCD 9 6 No 2 - ve Remission, off medication 2 M 3 Pred, MMF MCD 7 8 No 3 trace Remission, off medication 3 F 4 Pred, CyA MCD 11 6 Bronchiectasis Hypogamma-globulinemia 3 - ve Remission, on monthly IV IgG replacemen 4 F 5 Pred MCD 12 4 No 10 - ve Remission, off medication for 10 years 5 M 6 Pred, CyA, MMF MCD 10 12 Anaphylactoid reaction to last dose 2 4+ Pred, MMF, Tac 6 M 4 Pred, MMF MCD 9 4 No 5 - ve Remission, off medication for 5 years 7 M 2 Pred, CyA MCD 4 4 No 3 - ve Remission, on low-dose pred 8 M 3 Pred, MMF, CyA IgM Nephropathy 6 2 No 2 - ve Remission, on MMF 9 M 2 Pred, MMF IgM Nephropathy 4 4 No 3 - ve Remission, off medication 10 M 5 Pred, MMF MCD 10 3 No 9 - ve Remission, off medication for 9 years 11 M 4 Pred, MMF MCD 8 3 No 8 - ve Remission, off medication for 8 years 12 M 6 Pred, CyA MCD 12 7 No 3 - ve Remission, off medication 13 M 4 Pred, CyA MCD 6 2 No 2 Trace Remission, off medication 14 M 3 Pred, MMF, Tac IgM Nephropathy 5 3 Allergy, itching 2 - ve Remission on MMF 15 M 2 Pred, CyA FSGS 4 2 No 2 - ve Remission on CyA 16 M 2 Pred MCD 10 4 No 2 - ve Remission, off medication 17 M 4 Pred, CyA MCD 13 4 No 5 - ve Remission, off medication for 5 years No.: number, y: years, IS: immunosuppressive medication, RTX: rituximab, F: female, M: male, Pred: prednisolone, tac: tacrolimus, MMF: mycophenolate mofetil, CyA: cyclosporine A, MCD: minimal change disease, IgM: immunoglobulin M, FSGS: focal segmental glomerulosclerosis, IgG: immunoglobulin G, IV: intravenous
Pre-RTX drug No. of patients Response Partial response No response Steroid alone 2 2 0 0 Steroid + MMF 5 5 0 0 Steroid + CNI 7 5 2 0 Steroid + MMF +CNI 3 0 2 1 RTX: rituximab, No.: number, MMF: mycophenolate mofetil, CNI: calcineurin inhibitors
Pathology No. of patients Response Partially response No response MCD 13 (76.0) 11/13 1/3 1/13 IgM nephropathy 3 (18.0) 1/3 2/3 0 FSGS 1 (6.0) No 1/1 0 Total 17 (100) 12/17 4/17 1/17 Values are presented as number and precentage (%). No.: number, MCD: minimal change disease, IgM: immunoglobulin M, FSGS: focal segmental glomerulosclerosis