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- Table 1
- Factors that may increase fracture risk in patients with type 2 diabetes mellitus.
Increased bone fragility due to accumulation of advanced glycosylation end products Low bone turnover with reduction in unmineralized bone Inhibition of bone formation due to increased urine calcium loss caused by hyperglycaemia Use of thiazolidinediones and Sodium-glucose co-transporter-2 inhibitors Metabolic effects of nephropathy on bone Bone loss in the foot due to peripheral sympathetic neuropathy (diabetic neuroarthropathy) Increased risk of falling due to visual impairment, cardiovascular disease, hypoglycaemia, neuropathy and postural hypotension
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