The NLRP3 inflammasome rs35829419 C&gt;A polymorphism is associated with type 2 diabetes mellitus in Saudi Arabia

Yahia A. Kaabi

doi:10.15537/smj.2023.44.8.20230322

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Table 1

-Comparison of the demographic variables between type 2 diabetes mellitus patients and healthy control group.

Variables	T2DM (n=271)	Control (n=275)	P-values
Gender (male/female)	128/143	124/151	0.616
Age (years)	56.2±11.9	55.8±13.6	0.512
Weight (kg)	74.4±12.9	70.6±12.6	<0.0001
Height (cm)	161.8±8.6	163.3±7.3	0.015
BMI (kg/m2)	28.4±4.6	26.6±4.9	<0.0001
FPG (mmol/L)	13.4±5.6	5.7±1.0	<0.0001
HbA1c (%)	8.9±1.6	5.8±0.8	<0.0001

Values are presented as means ± standard deviations (SD). T2DM: type 2 diabetes mellitus, BMI: body mass index, FPG: fasting plasma glucose, HbA1c: glycosylated hemoglobin

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Table 2

-Allele change (frequency) of the nucleotide-binding oligomerization domain-like receptor pyrin domain-containing 3 rs35829419 single-nucleotide polymorphism among type 2 diabetes mellitus and control group.

SNP	Total (n=546)	T2DM (n=271)	Control (n=275)	HWE’s P-value	OR (95% CI)	P-values^*
CC	494 (90.5)	237 (87.4)	257 (93.5)	0.575	1.00	-
CA	51 (9.3)	33 (12.2)	18 (6.5)		1.99 (1.11-3.61)	0.027
AA	1 (0.2)	1 (0.4)	0 (0.0)		NA	NA
CA+AA	52 (9.5)	34 (12.5)	18 (6.5)		2.05 (1.16-3.75)	0.019
C	1039 (95.1)	507 (93.5)	532 (96.7)		1.00	-
A	53 (4.9)	35 (6.5)	18 (3.3)		2.04 (1.15-3.70)	0.016

↵Values are presented as numbers and precentages (%). *Fisher exact test. SNP: single-nucleotide polymorphism, T2DM: type 2 diabetes mellitus, HWE: Hardy-Weinberg equilibrium, OR: odds ratio, CI: confidence interval, NA: not available

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Table 3

-Basic characteristics of studied groups by nucleotide-binding oligomerization domain-like receptor pyrin domain-containing 3 rs35829419 genotype.

Variables	T2DM			Control
	CC	CA	P-values	CC	CA	P-values
Age (years)	56.4±11.6	59.2±13.9	0.192	56.2±13.9	54.7±9.6	0.329
Weight (kg)	73.5±11.8	78.2±9.9	0.032	70.6±11.1	66.9±15.6	0.188
Height (cm)	161.9±8.4	162.5±7.7	0.711	163.5±7.0	162.9±10.3	0.874
BMI (kg/m2)	28.1±4.2	29.7±4.2	0.031	26.8±4.3	26.0±4.3	0.677
FPG (mmol/L)	11.9±4.7	10.9±3.9	0.287	5.7±1.0	5.7±0.8	0.977
HbA1c (%)	8.9±1.8	8.5±1.4	0.179	5.9±0.5	5.3±0.4	0.191

Values are presented as means ± standard deviations (SD). T2DM: type 2 diabetes mellitus, BMI: body mass index, FPG: fasting plasma glucose, HbA1c: glycated hemoglobin