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Research ArticleOriginal Article
Open Access

Effect of platelet indices on postoperative pain and edema in bimaxillary surgery

Seher Orbay Yaşlı, Dilek Günay Canpolat, Fatma Doğruel, Selin Çelebi, Tekindal M. Agah and Demirbas A. Emin
Saudi Medical Journal September 2023, 44 (9) 889-897; DOI: https://doi.org/10.15537/smj.2023.44.9.20230291
Seher Orbay Yaşlı
From the Department of Oral and Maxillofacial Surgery (Yaşlı, Canpolat, Doğruel, Çelebi, Emin), Erciyes University, Faculty of Dentistry, Melikgazi, Kayseri; and from the Department of Biostatistics (Agah), İzmir Katip Çelebi University, İzmir, Turkey
MD
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  • ORCID record for Seher Orbay Yaşlı
  • For correspondence: [email protected]
Dilek Günay Canpolat
From the Department of Oral and Maxillofacial Surgery (Yaşlı, Canpolat, Doğruel, Çelebi, Emin), Erciyes University, Faculty of Dentistry, Melikgazi, Kayseri; and from the Department of Biostatistics (Agah), İzmir Katip Çelebi University, İzmir, Turkey
MD
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Fatma Doğruel
From the Department of Oral and Maxillofacial Surgery (Yaşlı, Canpolat, Doğruel, Çelebi, Emin), Erciyes University, Faculty of Dentistry, Melikgazi, Kayseri; and from the Department of Biostatistics (Agah), İzmir Katip Çelebi University, İzmir, Turkey
MD
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Selin Çelebi
From the Department of Oral and Maxillofacial Surgery (Yaşlı, Canpolat, Doğruel, Çelebi, Emin), Erciyes University, Faculty of Dentistry, Melikgazi, Kayseri; and from the Department of Biostatistics (Agah), İzmir Katip Çelebi University, İzmir, Turkey
DDS
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Tekindal M. Agah
From the Department of Oral and Maxillofacial Surgery (Yaşlı, Canpolat, Doğruel, Çelebi, Emin), Erciyes University, Faculty of Dentistry, Melikgazi, Kayseri; and from the Department of Biostatistics (Agah), İzmir Katip Çelebi University, İzmir, Turkey
phD
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Demirbas A. Emin
From the Department of Oral and Maxillofacial Surgery (Yaşlı, Canpolat, Doğruel, Çelebi, Emin), Erciyes University, Faculty of Dentistry, Melikgazi, Kayseri; and from the Department of Biostatistics (Agah), İzmir Katip Çelebi University, İzmir, Turkey
DDS, phD
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Article Figures & Data

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    Figure 1

    - The anatomic landmarks are selected and the area is calculated on Vultus 3-dimensional program.

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    Figure 2

    - Correlation between first-day postoperative edema amount and number of analgesic drugs administered in the 24th-72nd hours.

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    Figure 3

    - Correlation between third-day postoperative edema amount and number of analgesic drugs administered in the 24th-72nd hours.

Tables

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    Table 1

    - Comparison of platelet volume indices, the number of analgesic drug administrations in the first 24 hours and 24-72 hours postoperatively, and the amount of edema on the first and third days according to gender.

    CharacteristicsGenderTest statistics
    Male M (IQR)Female M (IQR)zP-value
    The amount of edema on the first day postoperatively (cm2) (T1-0)21.29 (11.11)21.71 (15.66)0.4980.619
    The amount of edema on the third day postoperatively (cm2) (T3-0)17.32 (8.67)21.26 (13.11)1.0510.293
    Number of IV analgesic drug applications for the first 24 hours postoperatively4.0 (2.0)4.0 (2.0)0.1930.847
    Number of IV analgesic drug applications in the 24-72 hours postoperatively2.0 (0.5)3.0 (1.0)1.8860.059
    PLT257.0 (67.0)292.0 (81.5)1.9910.047
    MPV10.00 (0.30)10.00 (0.00)1.7690.077
    PDW11.00 (3.00)12.00 (2.00)0.9700.332
    PCT0.20 (0.05)0.30 (0.10)1.9610.049
    PLCR25.90 (8.05)28.50 (6.55)1.7030.089
    • M: median value, IQR: inter-quartile ranges, z: Mann-Whitney U test standardized test statistic, PLT: platelet count, MPV: mean platelet volume, PDW: platelet distribution width, PCT: plateletcrit, PLCR: platelet large cell ratio, IV: intravenous line

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    Table 2

    - Correlation coefficients between dependent variables and independent variables adjusted for confounders.*

    Outcome measures PLTMPVPDWPCTPLCR
    The amount of edema on the first day postoperatively (cm2) (T1-0)r0.540†0.0960.2060.007-0.314†
    p<0.001†0.5150.1660.9630.032†
    The amount of edema on the the third day postoperatively (cm2) (T3- 0)r0.596†0.0520.1180.050-0.170
    p<0.001†0.7300.4330.7440.259
    Number of IV analgesic drug applications for the first 24 hours postoperativelyr0.1950.1270.1510.297†-0.200
    p0.2570.3950.3180.045†0.182
    Number of IV analgesic drug applications in the 24-72 hours postoperativelyr0.495†0.058-0.1800.2280.086
    p<0.001†0.6960.2250.1240.566
    • ↵* All paired comparisons have been adjusted according to the factors to which the compared variables are related.

    • ↵† Indicates statistically significant correlations. For example, when evaluating the relationship between the amount of edema on the third day postoperative day and platelet, corrections were carried out according to BMI, gender, MPV, PDW, PCT, and PLCR. PLT: platelet count, MPV: mean platelet volume, PDW: platelet distribution width, PCT: plateletcrit, PLCR: platelet large cell ratio, IV: intravenous line, r: Pearson correlation coefficient

    • View popup
    Table 3

    - Correlation of dependent and independent variables with variables considered to be confounding factors.

    Variables AgeBMIAmount of bleedingDuration of surgeryMaxillary advancementMaxillary impactionMandibular setbackMandibular advacement
    The amount of edema on the first day postoperatively (cm2) (T1-0)rho-0.131-0.150-0.0030.196-0.1780.0540.230-0.196
    p0.3660.2980.9810.1730.2160.7080.1070.172
    The amount of edema on the third day postoperatively (cm2) (T3-0)rho-0.079-0.107-0.0760.183-0.1820.0130.118-0.272
    p0.5870.4600.6020.1470.2070.9260.4150.056
    Number of IV analgesic drug applications for the first 24 hours postoperativelyrho-0.216-0.186-0.0530.2230.0620.320*0.039-0.147
    p0.1310.1960.7130.1200.6710.023*0.7890.310
    Number of IV analgesic drug applications in the 24-72 hours postoperativelyrho-0.141-0.0540.0140.049-0.0540.228-0.059-0.245
    p0.3300.7100.9260.7330.7110.1110.6820.086
    PLTrho-0.181-0.1330.0100.124-0.2230.099-0.090-0.155
    p0.2080.1180.9450.3910.1190.4960.5340.283
    MPVrho0.1380.0460.049-0.040-0.1830.0900.0770.153
    p0.3390.7520.7330.7850.2020.5360.5930.289
    PDWrho0.008-0.0720.1100.037-0.0720.0100.1320.024
    p0.9570.6200.4450.7970.6210.9460.3620.871
    PCTrho-0.159-0.1640.0280.082-0.2370.069-0.012-0.080
    p0.2700.1210.8480.5710.0980.6350.9340.582
    PLCRrho0.089-0.0540.063-0.028-0.1350.0160.0900.111
    p0.5390.7100.6660.8470.3510.9110.5340.444
    • ↵* Indicates statistically significant correlations. PLT: platelet count, MPV: mean platelet volume, PDW: platelet distribution width, PCT: plateletcrit, PLCR: platelet large cell ratio, IV: intravenous line, rho: Spearmen correlation coefficient

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Saudi Medical Journal: 44 (9)
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Effect of platelet indices on postoperative pain and edema in bimaxillary surgery
Seher Orbay Yaşlı, Dilek Günay Canpolat, Fatma Doğruel, Selin Çelebi, Tekindal M. Agah, Demirbas A. Emin
Saudi Medical Journal Sep 2023, 44 (9) 889-897; DOI: 10.15537/smj.2023.44.9.20230291

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Effect of platelet indices on postoperative pain and edema in bimaxillary surgery
Seher Orbay Yaşlı, Dilek Günay Canpolat, Fatma Doğruel, Selin Çelebi, Tekindal M. Agah, Demirbas A. Emin
Saudi Medical Journal Sep 2023, 44 (9) 889-897; DOI: 10.15537/smj.2023.44.9.20230291
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Keywords

  • orthognathic surgical procedures
  • platelets
  • postoperative complications
  • edema
  • pain
  • postoperative

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